Plasma risperidone levels and clinical response in patients with first-episode psychosis.
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Biomedical subjects
Swapna K Verma
Publications and source records attributed to Swapna K Verma.
Psychosis--a need for preemptive intervention?
With the advent of newer antipsychotic medications with fewer side-effects both clinicians and patients may be more willing to take early preemptive measures in treating psychotic disorders. We present a case report of use of pharmacotherapeutic intervention in an individual with either possible prodromal symptoms of schizophrenia or a subthreshold disorder. This case presented to us with the ethical dilemma inherent in treating a patient with subthreshold disorder. The options were either watchful waiting or preemptive treatment. In this case the patient was very distressed by his symptoms and had requested treatment with medications. Indeed, treatment has resulted in the remission of his symptoms and restored him to his previous level of functioning.
Adult↗
Substance abuse in schizophrenia. A Singapore perspective.
BACKGROUND: Most of the information on the prevalence and patterns of substance abuse in patients with schizophrenia has been from studies conducted in North America and Europe and data from Asian countries are conspicuously lacking. This study was undertaken with the aim to identify the prevalence and patterns of substance abuse among patients with first-episode schizophrenia in the city-state of Singapore. METHODS: All new patients with a diagnosis of first-episode schizophrenia or schizophreniform disorder who were seen in one calendar year in the only state mental institute in Singapore and its affiliated outpatient clinics were evaluated for a lifetime history of substance use. RESULTS: In a sample of 272 patients, 201 (73.6 %) were abstainers, 43 (15.8 %) had "mild" substance use and 28 (10.3 %) had "heavy" use patterns. Alcohol was the most frequently abused substance. The substance users were more likely to be males and were more likely to have a criminal record than abstainers. CONCLUSIONS: To our knowledge, this is the first study that examines the co-morbidity of substance abuse in schizophrenia in an Asian population. Our findings once again highlight the fact that patients with schizophrenia are at a high risk for substance abuse.
Adult↗