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Syed A Hoda

Publications and source records attributed to Syed A Hoda.

29 records · Page 2Linked to original sources

Practical considerations in the pathologic diagnosis of needle core biopsies of breast.

The success of needle core biopsy procedures and the validity of pathologic diagnoses made on material from the procedures are key determinants in planning the optimal management of a wide variety of breast diseases. The most common diagnostic problems encountered in these biopsy specimens include lobular and ductal proliferations, sclerosing and papillary lesions, cellular fibroepithelial tumors, and minimally invasive or microinvasive carcinoma. This review provides practical guidance to help narrow the differential diagnosis of lesions on needle core biopsies and offers guidelines for the pathologic reporting of these specimens.

Biopsy, Needle↗

Megakaryocytes mimicking metastatic breast carcinoma.

False-positive diagnosis of lymph nodes occurs when a benign element in a lymph node, or in its capsule, is interpreted as metastatic carcinoma. This report describes a patient with breast carcinoma who had megakaryocytes in axillary sentinel lymph nodes mimicking metastatic carcinoma. The patient had no history of a hematologic disease, and we found no evidence of a concurrent hematopoietic disorder. The megakaryocytes were reactive for CD31, CD61, and von Willebrand factor, but not for cytokeratin (AE1/AE3). Megakaryocytes should be added to the list of benign histologic abnormalities that may simulate metastatic carcinoma in a sentinel lymph node.

Adenocarcinoma↗

The need for vigilance in the pathologic evaluation of sentinel lymph nodes: a report of two illustrative cases.

The advent of sentinel lymph node (SLN) biopsy for breast cancer has had a considerable impact on clinical oncology. The SLN procedure has been widely adopted, but major clinical issues remain unresolved pending the outcome of randomized trials. Pathologic handling of SLNs is less controversial; however, significant pitfalls in their handling have been reported. Herein we report two additional uncommon situations that demonstrate the need for the utmost vigilance in both the macroscopic examination (i.e., trimming of "positive" nodal tissue) and microscopic examination (i.e., presence of nevus cell aggregates mimicking metastatic carcinoma) of SLN specimens.

Aged↗

Observations on the pathologic diagnosis of selected unusual lesions in needle core biopsies of breast.

Pathologic diagnoses rendered on needle core biopsies of mammary lesions are primary determinants of further intervention. Such biopsies are being performed for an ever-widening range of diseases in an attempt to reliably and efficiently render a diagnosis. This review is intended to provide practical guidance to pathologists in dealing with selected unusual lesions encountered in these biopsies. Herein we offer advice on avoiding common diagnostic errors and on considering the relevant differential diagnosis of mucocele-like lesions, spindle-cell metaplastic carcinoma, adenomyoepithelioma, pseudoangiomatous stromal hyperplasia (PASH), collagenous spherulosis, myofibroblastoma, vascular lesions, and lymphoid infiltrates in the breast.

Biopsy, Needle↗

Lupus mastitis.

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Adult↗