PubMed Health⌕ Search

Biomedical subjects

T A Anderson

Publications and source records attributed to T A Anderson.

11 recordsLinked to original sources
PubMed1991

Induction of self-tolerance in T cells but not B cells of transgenic mice expressing little self antigen.

Self-tolerance to a transgene-encoded protein, hen egg lysozyme, was examined in the T and B cell repertoires of a series of lines of transgenic mice that expressed different serum concentrations of soluble lysozyme. T cells were tolerant in all lines in which lysozyme was expressed irrespective of the antigen concentration, whereas B cell tolerance did not occur when the serum lysozyme concentration was less than 1.5 nanograms per milliliter (0.1 nM). Induction of elevated transgene expression could restore B cell tolerance. These findings support the hypothesis that autoimmune disease may in some instances arise through a bypass of T cell tolerance.

Animals↗
PubMed1991

Crystallization and preliminary analysis of telokin, the C-terminal domain of myosin light chain kinase.

Telokin, an acidic protein related to the C-terminal portion of smooth muscle myosin light chain kinase from turkey gizzard has been crystallized in a form suitable for a high-resolution diffraction analysis. The crystals were grown from solutions of polyethylene glycol 8000 using the hanging-drop vapor diffusion method. They belong to the trigonal space group P3(1)21 or P3(2)21 with cell parameters a = 64.0 A, c = 59.4 A and diffract to at least 2.7 A resolution.

Animals↗
PubMed1990

Microbial degradation of trichloroethylene in the rhizosphere: potential application to biological remediation of waste sites.

The possibility that vegetation may be used to actively promote microbial restoration of chemically contaminated soils was tested by using rhizosphere and nonvegetated soils collected from a trichloroethylene (TCE)-contaminated field site. Biomass determinations, disappearance of TCE from the headspace of spiked soil slurries, and mineralization of [14C]TCE to 14CO2 all showed that microbial activity is greater in rhizosphere soils and that TCE degradation occurs faster in the rhizosphere than in the edaphosphere. Thus, vegetation may be an important variable in the biological restoration of surface and near-surface soils.

Biodegradation, Environmental↗
PubMed1977

Commercial infant foods: content and composition.

The relative contribution of strained foods to total dietary caloric distribution is important when assessing the appropriateness of a particular food choice. Because protein intakes by most infants in the United States are generous, the high carbohydrate content of the typical strained food can be helpful in adjusting the distribution of calories. The fat content of most strained foods is low and those foods higher in fat are also comparatively high in protein content. Therefore it is difficult to find strained foods to contribute greater amounts of dietary fat without also increasing the percentage of calories in the form of protein. For this reason it is not possible to achieve a satisfactory distribution of calories in the diet of an infant fed skim milk. With the exception of home-prepared fruits with low sugar content, baby food prepared in the home will probably have a higher caloric density than commercial products. Care should be taken not to overfeed infants when feeding home-prepared baby foods. The appropriateness of United States baby foods for use in developing countries and a physiological rationale for age of introduction of strained foods were discussed. A basic need is to ensure that the strained foods of the future are formulated with emphasis given to nutritional need and least cost, as well as to mother's taste and to the manufacturer's profit.

Developing Countries↗
PubMed1976

Influence of fat and carbohydrate content of diet on food intake and growth of male infants.

Two groups of normal fullterm infants were studied from 8 to 112 days of age while receiving formulas of the same caloric density and prepared from the same ingredients. A limited selection of strained foods were permitted. From the combination of formula and strained foods, one group received 29% of calories from fat and 62% from carbohydrate whereas the other received 57% from fat and 34% from carbohydrate. Fifteen infants in each group completed the study as planned. Energy intakes per kilogram and rates of gain in length and weight were similar in the two feeding groups.

Body Weight↗
PubMed1976

The effect of dietary sodium chloride on blood pressure, body fluids, electrolytes, renal function, and serum lipids of normotensive man.

Eight normotensive white middle-aged men were given low, moderate, and high salt diets with constant potassium intakes each for periods of at least 4 weeks. There was a tendency for body weight, serum sodium, exchangeable sodium, and inulin space to increase. Indirect blood pressure measurements revealed no change in blood pressure, either supine or upright measurements, during the 3 study intervals. Inulin clearance (and presumably glomerular filtration rate) rose with increase in dietary salt. Urinary potassium excretion rose progressively as salt intake increased. Total body potassium tended to decrease with increase in dietary salt. There was no changes in the excretion of calcium, magnesium, phosphorus, nor were there changes in the blood level of potassium. There was no change in total body water. The serum cholesterol and triglyceride levels were not appreciably affected by the different dietary sodium intakes. Plasma renin activity and urinary aldosterone excretion rose progressively with the two levels of sodium restriction. These studies indicate that normal man is able to compensate for large differences in sodium intake with minor metabolic changes. These changes do not necessarily lead to hypertension over a one-month period. Nevertheless, many hemodynamic and hormonal compensatory mechanisms come into play. It is evident that hypertension might result should the sodium load not be excreted, the circulating volume become too great for the excretory capacity, or if neural or endocrine adjustments be inadequate.

Adult↗
PubMed1975

Influence of formula concentration on caloric intake and growth of normal infants.

Fifteen fullterm female infants were enrolled in each of two feeding groups and all but one completed the proposed period of observation to age 112 days. Formulas prepared from the same ingredients (fat-free milk solids, a mixture of corn and coconut oils, lactose, vitamins and minerals) were fed ad libitum to both groups. Formula concentration was 54 kcal/100 ml for one group and 100 kcal/100 ml for the other. A limited selection of commercially prepared strained foods was permitted after 28 days of age. Weighed intakes of food were recorded for each day of study. During the internal 8 through 41 days of age, the infants fed the 54 kcal/100 ml formula consumed a considerably greater quantity of food but fewer calories than did those fed the 100 kcal/100 ml formula. Those fed the 54 kcal/100 ml formula also gained less weight. These differences between feeding groups were statistically significant. After 41 days of age, mean caloric intakes (kcal/kg/day) and rates of gain in weight were similar for the two feeding groups. The data provide a basis of speculation on the possible difference in allocation of calories to growth and non-growth in the two groups.

Age Factors↗