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Biomedical subjects

T A Bektemirov

Publications and source records attributed to T A Bektemirov.

At least 19 recordsLinked to original sources
PubMed1981

Antiviral activity of substituted 6-methylmercaptopyrazolo(3,4-d)pyrimidines and their ribosides.

The antiviral activities of pyrazolo(3,4-d)pyrimidines and their nucleosides, divided into 7 groups based on the substituent in position 4 (mercapto-, methylmercapto-, amino-, hydrazine-, dialkyl amino-, oxy-, and methoxyderivatives), were studied against herpes simplex virus type 1 (HSV 1) and vaccinia virus. Numerous compounds inhibited the virus yields by 1-4 log CPD50. Most antiviral compounds inhibited HSV 1 more than vaccinia virus. Only methylmercapto- derivatives inhibited both viruses approximately to the same degree.

Antiviral Agents↗
PubMed1981

[Interferon as a protector in human cells treated with 4-nitroquinoline-1-oxide].

Interferon having the activity 25-37 and 375 IU/ml decreases the frequency of chromosome aberrations induced with the cancerogen 4-nitroquinoline-1-oxide in diploid human cells. The protective effect of interferon is not connected with stimulation or inhibition of cell division. It has been revealed that interferon with the activity 25-37 IU/ml has a stimulating effect on mitotic activity of cells, while interferon with the activity 375 IU/ml inhibits cell division.

4-Nitroquinoline-1-oxide↗
PubMed1976

[The state of several indices of non-specific immunity in rats with nephrotoxic glomerulonephritis].

Changes in the interferon reaction of leukocytes, bactericidal property of the blood serum against the E. coli and streptococcus, the activity of beta-lysins in experimental nephrotoxic glomerulonephritis reproducible with the aid of heterogenous nephrotoxic serum in mongrel male rats were studied. This model permitted to trace the changes in the nonspecific protection mechanisms depending on the pathological process in the kidneys. In nephrotoxic glomerulonephritis the most pronounced changes were seen in the interferon reaction of leukocytes: it decreased up to 90% in comparison with the normal depending on the duration of the disease. In difference from this the changes in the anti-bacterial immunity indices were observed at the period of marked nephrotic process activity.

Animals↗