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Biomedical subjects

T A Danilova

Publications and source records attributed to T A Danilova.

At least 19 recordsLinked to original sources
PubMed2005

Counts of stromal precursor cells in heterotopic bone marrow transplants in mice immunized with group a streptococcus antigens.

The count of stromal precursor cells in bone marrow transplants from CBA mice, transplanted to animals immunized with killed type 5 group A streptococcus vaccine, decreased 4.5-6.5 times (depending on the transplant age) in comparison with the grafts transplanted to normal recipients. The counts of stromal precursor cells in 1.5-3-month bone marrow transplants from animals immunized with killed streptococcal vaccine transplanted to normal mice were virtually the same, while in 7-month transplants they decreased 2-fold in comparison with their counts in bone marrow transplants from normal CBA mice transplanted to normal animals. The content of stromal precursor cells in the femoral bone marrow of animals immunized with killed streptococcal vaccine was appreciably (3.5 times) higher than in the bone marrow of normal mice. The results attest to an appreciable effect of streptococcal antigens on the bone marrow stromal tissue and suggest that not all stromal precursor cells, whose count increases after injection of antigens, are responsible for transplantability of the stromal tissue in case of its heterotopic transplantation.

Animals↗
PubMed1986

[Inhibition by alpha-D-galactose of heterophilic antibodies against the antigens of the interstitial connective tissue of the myocardium].

The reaction of heterophile antibodies with interstitial connective tissue cells of bovine myocardium was inhibited with alpha-D-galactose. D-glucose, D-mannose, L-fucose, N-acetylgalactosamine and other monosaccharides demonstrated the lack of inhibitory activity. Disaccharide melibiose and trisaccharide raffinose containing terminal alpha-galactose also had an inhibitory effect on the reaction of sera with bovine myocardium. The results show that heterophile antibodies to heterophile bovine antigen revealed in rheumatic patients' sera differ from antibodies to I and i antigens and T-antibodies, whose specificity is associated with terminal beta-galactose. They also differ from other heterophile antibodies described earlier.

Animals↗
PubMed1985

[Heterophile antibodies to the antigens of myocardial interstitial connective tissue and erythrocytes in animals of different species].

Reactions of heterophilic antibodies with antigens of the interstitial connective tissue (ICT) of the myocardium of different animals were studied and compared. The reactions were identical on bovine, pig, sheep and rabbit myocardium. The heterophilic antigen of the ICT of bovine myocardium was also found on bovine, rabbit and rat red cells and was absent on sheep red blood cells. It is suggested that heterophilic antigen of the ICT of the bovine myocardium is a novel heterophilic antigen, the specificity of which is linked with D-galactose and which differs from antigens of other heterophilic systems.

Animals↗
PubMed1985

[Cytotoxic antibodies to thymocyte antigens in rheumatism and other diseases].

Cytotoxic antibodies reacting with mouse and human thymocytes were detected in rheumatic patients' sera. The level of cytotoxic antibodies was considerably higher in active than in inactive process. A correlation was found between the antibody level and the clinical course of rheumatic fever. The cytotoxic index was the highest in sera of patients with acute rheumatic fever. Thymocytotoxic antibodies were also found in other autoimmune diseases. In sera of normal individuals, antibodies to thymocytes were revealed rarely and in small quantities. A possible role of thymocytotoxic antibodies as a cause of deficit of T suppressors in autoimmune diseases is discussed.

Animals↗
PubMed1982

[Antibodies to fibroblast antigens in the sera of rheumatism patients].

The sera from patients with active rheumatic fever possess unmarked ability to react with antigens of human fibroblasts. More intense reactions were obtained with guinea-pig fibroblasts. In rheumatoid arthritis, positive reactions with human and guinea-pig fibroblasts were disclosed in half of the test sera. No complement-dependent cytotoxic antibodies were found in the patients' sera.

Adult↗
PubMed1981

Studies of Fc receptors of heart valve and joint fibroblasts.

Normal human and rabbit sera, and the IgG isolated from them, have been shown by immunofluorescence to react with bovine and human heart valve fibroblasts. Analogous results were obtained with sera of children under the age of 2. Positive reactions were observed also with fibroblasts, chondrocytes and osteocytes of human fetal joint tissues. The reactions are mostly due to monomeric immunoglobulins, since soluble immune complexes give much weaker reactions with the fibroblasts. The reactions are apparently dependent on the presence of Fc receptors on these cells. This conclusion is confirmed by positive reactions with IgG Fc fragments, with pure antibodies to ovalbumin and with human monoclonal IgG. The monoclonal IgG1 possesses the strongest ability to bind with fibroblast Fc receptors. No Fc-IgG receptors have been revealed on the fibroblasts and other structures of the interstitial connective tissue of human and bovine myocardium.

Adult↗
PubMed1981

[Immunological indices in acquired heart defects after heart valve replacement with bioprostheses].

The indices of cellular and humoral immunity were studied in 46 patients with heart diseases of rheumatic origin prior to and alter operation for replacement of the heart valves with synthetic prostheses (in 19) and pig aortic valves treated with glutaraldehyde and methaperiodate solutions ater Karpantje (in 27). The indirect fluorescence method and the leukocyte migration inhibition test to the myocardial antigens showed that the operation for valve prosthetics causes an increase in the content of antibodies and activation of specific leukocyte sensitization to the antigens of the myocardium and heart valves. These changes do not depend on the type of the valve prosthesis and are normalized by the 6th month. The activation of immunological processes encountered in some patients in late periods after the operation (1-8 years) corresponded to an aggravation of their clinical condition which in most cases was not associated with impaired functioning of the biological prosthesis. The implantation of xenogenous valve prostheses treated by Karpantje's method did not cause the development of immunological processes which could have induced destruction of the prostheses.

Antibodies↗
PubMed1980

[Ordering of antibodies, that react with cardiac muscle fiber and interstitial connective tissue antigens, in different immunoglobulin classes].

Sera of patients suffering from rheumatic diseases and myocarditis were examined on the sections of human and bovine myocardial tissue by indirect immunofluorescence with the use of pure IgG antibodies or monospecific sera against IgG, IgA and IgM. It was shown that antibodies reacting with different myofibers and interstitial connective tissue of the heart belong to the main immunoglobulin classes (IgG, IgA and IgM). There was a significant predominance of IgG antibodies as shown by the frequency of their detection and by the titer height. The predominance of antibodies to certain classes of immunoglobulins did not correlate with a specific disease entity. The frequency of detecting antibodies to a certain immunoglobulin class was in good agreement with the time of the disease onset. Moreover, the frequency of positive reactions due to IgG, IgA, and IgM antibodies correlated with the level of the appropriate immunoglobulins in the test sera.

Adult↗
PubMed1980

[Antibodies to myocardial muscle fiber sarcolemmic antigens in rheumatism and other heart diseases].

The work discusses the results of studying by indirect immunofluorescence and the passive hemagglutination test antibodies to sacolemma antigens of myocardial muscle fiber in patients with rheumatic fever as compared to those in patients with affection of myocardium of nonrheumatic origin. The frequency of the detection of antibodies to sarcolemma antigens in sera of patients with rheumatic fever by immunofluorescence correlates with the activity of the process. No differences were revealed in the frequency of detection of antibodies reacting with sarcolemma in rheumatic fever and in other heart diseases in the active phase. Antibodies to sarcolemma antigens contained in HCL-extracts from human myocardium preparations, which are detected in the passive hemagglutination test are revealed significantly more often in sera of patients with rheumatic fever. Control experiments with IgG fractions obtained from whole sera were conducted to remove any possible nonspesific reactions of tissue extracts with the sera tested.

Antibodies↗
PubMed1980

[Heart valve fibroblast Fc receptor study and the search for similar receptors in other tissues].

The data are confirmed about the presence of Fc-receptors reacting with human and rabbit IgG on the fibroblasts of human and bovine heart valves. It is shown the similar receptors are present on the fibroblasts of joints and L-cells. The receptors react largely with monomeric IgG. Clear-cut distinctions are revealed between the fibroblasts of heart valves and those of the myocardium which like other cells of myocardial interstitial connective tissue do not contain Fc-receptors.

Animals↗
PubMed1979

[Antibodies to muscle fiber antigens in the cosmonauts after a space flight].

The study of serum samples, obtained from 15 cosmonauts before and after space flights, with the use of the indirect fluorescent method showed that in 7 cosmonauts antibodies to different elements of the human heart muscle appeared after flights. Strong and very strong luminescence of the elements of heart muscle tissue was detected in the cosmonauts after the third space flight. When studying the sera on sections of bovine heart muscle tissue, the reactions of the sera taken before and after flights were found to have no essential differences.

Animals↗
PubMed1979

[Reactions of normal human and rabbit immunoglobulins with heart valve fibroblasts].

It was demonstrated using the indirect immunofluorescent technique that normal human and rabbit sera, and IgG isolated from them intensively reacted with fibroblasts of human and bovine heart valves. The results obtained with Fab and Fc fragments of IgG sugges that this reaction is due to the Fc region of the IgG molecule and related to the presence of the Fc receptor on fibroblasts of heart valves.

Animals↗
PubMed1977

[Antibodies to heart valve fibroblasts in the sera of rheumatic patients].

The antibodies reactive in immunofluorescence with the fibroblasts of human and bovine heart valves were isolated from the rheumatic patients' sera with the aid of immunoadsorbent prepared from human heart valve tissue. No reaction between the antibodies and the fibroblasts of the interstitial connective tissue of the myocardium was observed. It seems that the fibroblasts of the heart valves and the myocardium contain different antigens; the presence of common antigenic components in human and bovine valve fibroblasts is shown.

Antibodies↗
PubMed1976

[Study of antibodies to heterologous connective tissue, isolated from sera of patients with rheumatism].

Antibodies against connective tissue elements of various bovine organs were isolated from the sera of rheumatic fever patients with the aid of immunosorbents (bovine connective tissue extract and erythrocyte stroma). The antibody preparations obtained were not identical and contained antibodies against different antigens of bovine connective tissue. The antibody preparations failed to react with human connective tissue components.

Antibodies↗