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Biomedical subjects

T A Flam

Publications and source records attributed to T A Flam.

24 records · Page 2Linked to original sources

Experimental study of hollow, absorbable polyglycolic acid tube as stent for vasovasostomy.

Bilateral vasovasostomy in 16 rats permitted evaluation of a microsurgical technique using an original absorbable hollow stent made of polyglycolic acid. Advantages of this stent included ease of anastomosis, maintenance of luminal patency, satisfactory approximation of vasal ends, and reduction of perivasal inflammation possibly due to reduction of extravasation of sperm. Absorbable stents were eliminated within four weeks of placement, and patency was confirmed by histologic studies performed two, four, and six weeks after vasovasostomy.

Animals↗

Delayed nonurothelial metastatic lesions to the penis: a report of two cases.

Metastatic lesions to the penis are uncommon and originate most often from other genitourinary primaries. Diagnosis is usually easy, as the primary is already known in most cases. The metastases can very rarely be isolated and delayed for several years after the treatment of the primary tumor. We report two cases of penile metastases from nonurothelial primary lesions. A sigmoid adenocarcinoma was the primary in one case, a renal adenocarcinoma in the other. These two cases were distinctly unusual, as the metastases were delayed for several years after the treatment of the primary. Treatment was palliative with early death in both cases.

Adenocarcinoma↗

[2 cases of testicular seminoma associated with HIV infection. Analysis of treatment tolerance].

Two homosexuals with advanced HIV infection and testicular seminoma stage IIb and IIc were treated with irradiation associated with chemotherapy in one patient. Subdiaphragmatic irradiation was followed by moderate diarrhoea. Initial chemotherapy consisted of cisplatinum, vinblastine, bleomycin replaced by cyclophosphamide after radiotherapy. The use of cyclophosphamide was discontinued after 2 courses due to neutropenia (less than 1500/mm3). Complete tumor remission was achieved in both patients without infection in spite of an aggravation of the CD4 deficit (5/mm3, 52/mm3). The patients died of opportunistic infections 14 and 12 months after terminating treatment. We conclude that cytotoxic and radiation treatment can be administered safely if carefully monitored in these severely immunodepressed patients.

Adult↗

Changing concepts in surgical management of renovascular hypertension.

As newer surgical techniques and concepts have emerged, including revascularization of the totally occluded renal artery and alternatives to aortorenal bypass (hepatic, splenic, or iliac artery to renal artery grafts), our patient population has changed. Patients with diffuse atherosclerotic disease, bilateral renal artery stenosis, totally occluded renal arteries, and azotemia are being referred for renal revascularization, thereby changing the indications for operation and the results that can be anticipated. Although our results in patients operated on solely for uncontrollable hypertension or renal failure have been successful, much work needs to be done to improve the results obtained when patients have a combination of uncontrollable hypertension and renal failure.

Arteriosclerosis↗

Complications of ureteroscopy.

Ureteroscopy with the rigid instrument is now an integral part of the endourologic armamentarium for the management of patients with ureteral calculi. Our experience demonstrates that ureteroscopy can be a safe, efficacious, and less invasive modality. Morbidity will be lowered with proper patient selection, meticulous attention to technique, and use of the proper equipment. Prevention is the best way to avoid serious complications of ureteroscopy. The following guidelines are recommended: Ureteroscopy should be used primarily for patients with distal ureteral calculi. A guidewire should be in place at all times during ureteroscopy. Fragmentation devices should be available. No forceful manipulations should be undertaken during either introduction of the instrument or manipulation of the calculus. When access or manipulation is difficult, a stent should be placed in the ureter for ureteroscopy at a later date. When perforation occurs, a stent should be placed in the ureter and the injured dry unstented ureter complex avoided. Alternative endourologic modalities should be used when appropriate. When practicing urologists are aware of the indications, potentials, and limitations, ureteroscopy and other endourologic methods will permit safe successful treatment of most patients with ureteral calculi.

Adult↗

[Rigid uretero-renoscopy: critical study of a series of 116 consecutive patients].

We have reviewed the first 116 cases of uretero-renoscopy using rigid ureteroscopes. Procedures were done for either diagnostic or therapeutic purposes (27 and 2 respectively), and for stone manipulation (87). The overall success rate for stone removal was 73%. The success rate for removal of stones the proximal two-thirds and distal third of the ureter were 38% and 83% respectively. Stones larger than 10 mm. Were successfully removed in 64% of cases. In 13 cases (11%), ureterolithotomy was necessary to successfully remove the stone. Diagnostic ureteroscopies for pathology of the ureter were 100% successful. The factors which affected success and failure rates, e.g. stone size, stone composition, ureteral abnormality and operator experience are delineated.

Adult↗