PubMed Health⌕ Search

Biomedical subjects

T A Gicheva

Publications and source records attributed to T A Gicheva.

10 recordsLinked to original sources
PubMed1988

Modelling coxsackie-virus infection in pregnant mice in long-term experiment.

The effect of virus infection on the organism of pregnant mice and their posterity was studied in experiment. The animals were infected with the prototype strain A13 (Flores) of Coxsackie virus which was administered on days 4, 7, 11, 15 and 19 of pregnancy. It has been demonstrated that pregnant mice are much more sensitive to the virus than non-pregnant females and that the placenta, along with the striped muscles, is the main reservoir of the virus. The obtained results also suggest that the virus penetrates into the tissues of the embryo most intensively in the second half of pregnancy and that the duration of manifestation of the virus in the tissues of the embryo depends on the period of intrauterine development. The study of the model system (long-term organ culture of the tissues of the organism) enabled us to establish a new fact of the cytoproliferative activity of A13 Coxsackie virus in the organ culture and in the placenta of mice infected in vivo, and also in the organ culture of the liver of their newborn, which is important for the confirmation of clinical observations presuming a high probability of intrauterine infection by the mentioned virus with its subsequent protracted persistence in the organism of the newborn.

Animals↗
PubMed1988

[Plasmapheresis in clinical practice].

The authors presented their experience of the use of intermittent plasmapheresis in 220 children with bacterial-inflammatory and immune-mediated diseases characterized by extreme severity and refractoriness to common therapeutic methods. Its use against a background of adequate etiological and pathogenetic therapy was shown to improve therapeutic results. In virus hepatitis with liver insufficiency, bullous erythema and hemorrhagic vasculitis plasmapheresis can be used as an independent method. Differentiated programs of the use of plasmapheresis were proposed, its safety was shown.

Bacterial Infections↗
PubMed1980

[Organ culture of the liver of sucklings born to mice infected with viruses during pregnancy].

The growth and proliferation of organ liver cultures from sucklings born to mice infected with Coxsackie A 13 virus during pregnancy have been studied. In liver explants of the experimental group of sucklings, a well defined zone of of growth, mostly of epithelial cells, was observed early, whereas the cell growth around liver explants of sucklings born to control female mice was either absent or very weak.

Animals↗
PubMed1978

[Growth of organ cultures of mouse liver infected with Coxsackie A13 virus].

Peculiarities attending the growth and proliferation of the organ cultures of the liver of mongrel albino mice infected once with Coxsackie A-13 virus were investigated. A marked zone of growth, mostly of the epithelial cells, was determined rather early in the liver explants of mice in the experimental group, whereas in control group of mice the cell growth around the explant of the liver was either absent or very weak. Besides, a great number of lymphocytes evenly arranged in the zone of hepatocytes growth was observed in the preparations of the experimental mice liver. Lymphocyte "adhesion" to hepatocytes of the culture was revealed in some preparations. Moreover, destruction of the hepatocytes and a marked rarefaction of the cell layer occurred at the sites of lymphocytes accumulation on the 21st and the 28th days of growth.

Animals↗