PubMed Health⌕ Search

Biomedical subjects

T A Korol'kova

Publications and source records attributed to T A Korol'kova.

At least 19 recordsLinked to original sources
PubMed2006

Emotionality and the temporospatial organization of instantaneous EEG potentials.

The characteristics of the temporospatial organization of cerebral cortical potentials at different levels of genetically determined emotionality were analyzed by constructing topograms of instantaneous EEG levels in the inbred rat strains MR and MNRA. Two parameters were calculated for each topogram: the total level and the similarity coefficient. Power spectra were calculated for the values and these were found to change in an oscillatory manner. Interstrain differences were found in the correlated changes in total levels and similarity coefficients, in the durations of changes in the total level, which were more marked than those of similarity coefficients, and the nature of interhemisphere asymmetry. In MR rats, the power spectra of both measures showed significant peaks with modes at 2.0, 6.5, and 9.0 Hz. In MNRA rats, peaks in the spectra of these measures both coincided (2.0 Hz) and differed (7.0 Hz in the spectrum of the total level and 3.0, 4.5, and 6.0 Hz in the spectrum of the similarity coefficient). These data suggest different types of functioning of the reticulothalamocortical and hippocampocortical systems in rats of these strains.

Animals↗
PubMed2000

[EEG study of the anxiolytic effect of scopolamine].

Effect of the central M-cholinolytic scopolamine on spatial organization of the rat brain electrical activity was studied under conditions of high and low emotional-stress responses. The EEG changes were estimated by 840 parameters. A possibility of the EEG discrimination by means of interstrain differences in responses to scopolamine, was shown. A more obvious decrease in spectral power and potentials coherence was revealed in Maudsley Reactive rats (MR) as compared with the Maudsley Nonreactive rats (MNRA), in parieto-temporal and occipital areas of the right hemisphere, and the reverse interrelationship occurred in the anterior parts of the right and posterior parts of the left hemisphere. These findings suggest some specifics in the spatial distribution of the maximum scopolamine action foci depending on the initial emotional level. Changes occurring under the scopolamine effect in different EEG frequency bands are different in the MR and the MNRA rats. The findings are discussed in respect to the EEG indices of anxiolytic component of cholinergic regulation of the brain activity.

Animals↗
PubMed1991

[Study of the topographic organization of cortical electric activity during hypnotic analgesia].

Experiments on 10 right-handed subjects were carried out to study the topographic organization of cortical activation processes by means of toposcopy of synchronous electric activity in hypnotic analgesia. The authors demonstrate the priority role of the anterior cortical areas of the left hemisphere in analgesia effects, which is connected with their importance in data realization and formation of the motivation affective component of painful sensation. Experiments have shown different manifestations of the functioning of diffuse nonspecific and local specific activation processes maintaining sensory analysis of painful stimuli and their affective cognitive estimation in the systems responsible for individual tolerance to painful sensations and analgesia effects and demonstrated a possibility of observing at the level of objective electrophysiological parameters of the phenomenon of pain components dissociation as one of the mechanisms of hypnotic analgesia.

Action Potentials↗
PubMed1977

[Excitability of the senso-motor cortex and red nucleus of rabbits with different levels of cortical potential spatial synchronization].

The motor reaction of the rabbit to the threshold electrical stimulation of the sensomotor cortex and red nucleus was studied to determine excitability of these structures. Under conditions of the computer-controlled experiment the excitability of the two structures was compardd for situations characterized by different levels of cortical potential correlation. An increase in the spatial synchronization of the cortical potentials is shown to be accompanied by intensification in excitability of the sensomotor cortex and red nucleus. This intensification seems to be one of possible neurophysiological mechanisms of the probability increase for the effector reaction to sensory stimuli when the cortical spatial synchronization rises.

Animals↗