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Biomedical subjects

T A Loginova

Publications and source records attributed to T A Loginova.

9 recordsLinked to original sources
PubMed1997

[Vibration bouginage in the cicatricial strictures of esophagus].

In 66 patients for the dilation of the cicatricial stricture of the esophagus vibration method was used. In 48 patients the vibrator was attached to proximal end of the bouge, in 18 patients the vibration device was introduced directly in the area of the stricture. The suggested method provided an easy and fast dilation of the stricture in 63 patients. In 3 cases surgical treatment was carried out because multiple strictures in separate areas resulted in complete obliteration of the esophagus. There were no complications due to the vibrobouginage. For the treatment of inflammatory disorders of the esophagus and for prophylaxis of the scar formation in the area of stricture in 29 patients the therapeutic laser irradiation was used. This treatment has ensured promising results.

Adolescent↗
PubMedDate not supplied

[Production and properties of an immobilized enzyme preparation with peptidase activity].

A heterogeneous multienzyme preparation with the peptidase activity, isolated from the cells of Pseudomonadacea bacteria, was immobilized on alumina. The specific activity of the immobilized enzyme complex is not a simple function of the bound protein quantity, but depends on immobilization conditions. An additional glutaraldehyde treatment results in higher thermostability of the immobilized enzyme preparation. The substrate specificity of the preparation retains after immobilization, and it becomes less sensitive to pH changes.

Aluminum Oxide↗
PubMedDate not supplied

[Casein hydrolysis by immobilized protosubtilin].

A study was made of the kinetics of sodium caseinate hydrolysis by protosubtilin G10X (Bac. subtilis producer) immobilized on silica gel with the aid of glutar dialdehyde. Optimal conditions for making the process were selected (pH 8.5, temperature 60 degree C, substrate concentration 0.3%). The apparent kinetic parameters of the reaction were calculated. An empiric equation that can be used for practical calculation was derived from the Michaelis-Menten equation with the use of the values obtained (Km = 2.48 +/- 0.10 micrometer/ml, Vmax = 25.6 +/- 1.9 micrometer/min/mg conventional protein).

Bacillus subtilis↗
PubMedDate not supplied

[Optimization of protein hydrolysis by Bacillus subtilis alkaline proteinase].

Casein hydrolysis by alkaline proteinase from Bacillus subtilis str. 72 had been investigated. It has been shown that the hydrolytic rate depends on the substrate concentration and declines rapidly with time even at low protein concentrations. It has been suggested to use an equation describing the time dependence of the rate of casein proteolysis and characterizing the optimum time of protein hydrolysis, maximum rate of hydrolysis, and the maximum yield of the reaction products.

Bacillus subtilis↗
PubMedDate not supplied

[Endoscopic diagnosis and treatment of cicatricial esophageal strictures].

The paper summarizes the experience gained by the authors in 10-year treatment of esophageal cicatricial strictures. Work-up and treatment results available on 107 relevant patients provided evidence on the leading role of endoscopic diagnosis in cicatricial strictures, while endoscopic bouginage is effective treatment of the strictures. To prevent recurrences esophageal bouginage should be combined with drug and laser therapy. The immediate response was reached in 91 (85%) patients. Long-term response was good only in 34 (46.6%) patients. Six slight complications passed off without special treatment.

Adolescent↗
PubMedDate not supplied

[The role of fiber endoscopy in the treatment of patients with chronic stenosis of the hollow organs of the neck].

Forty-eight patients with laryngeal, tracheal, and esophageal stenoses were treated making use of flexible endoscopes of various diameters and a kit of special instruments. Indications for endoscopic treatment were the presence of an 'overhang' along the upper edge of tracheostoma, laryngeal and tracheal granulation, cicatricial strictures of the esophagus with a lumen of less than 5 mm in diameter. Use of flexible endoscopes with a kit of special instruments helped do without many-staged surgical treatment in 20% of patients with chronic stenoses of hollow organs of the neck.

Adolescent↗