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T A Mihas

Publications and source records attributed to T A Mihas.

11 recordsLinked to original sources
PubMed1997

Effects of fructose-1,6-diphosphate on the activity of rat liver nitric oxide synthase in vitro.

Fructose-1,6-diphosphate (FDP) was found to cause significant stimulation of nitric oxide synthase (NOS) in rat liver homogenates in vitro. This effect was more pronounced for the inducible isoform than its constitutive counterpart. Furthermore, FDP restored rat liver inducible NOS levels following their depletion by carbon tetrachloride (CCl4). This finding may have further practical implications in hepatoprotection from various noxious chemical and biological agents.

Animals↗
PubMed1991

Effects of gastrointestinal hormonal peptides on the transformation of human peripheral lymphocytes.

The gastrointestinal peptides secretin and cholecystokinin were found to inhibit the incorporation of 3H-thymidine in the lymphocyte transformation reaction in response to phytohemagglutinin. Both peptides inhibited lymphocyte activation in a dose responsive fashion. This inhibition was not due to the toxicity of these substances, as the lymphocytes remained intact and capable of excluding trypan blue. Neither glucagon nor gastrin had any effects of lymphocyte transformation.

Adult↗
PubMed1990

Modification of the hepatotoxicity of D-galactosamine in the rat by an anti-endotoxin.

We have investigated the effects of polymyxin B and gentamicin on the histologic and biochemical alterations caused by D-galactosamine in the rat. Polymyxin B, but not gentamicin, protected against galactosamine-induced liver injury. There was good correlation between the biochemical data and the morphologic changes. This study suggests that endogenously produced endotoxin contributes to the extent of the hepatic damage caused by galactosamine. It is likely that the ability of the liver to detoxify small amounts of bacterial lipopolysaccharides absorbed from the gut is impaired after the preceding galactosamine injury.

Animals↗
PubMed1989

Herpes viruses and duodenal ulcer disease.

Antibodies to herpes simplex virus and Epstein-Barr virus were sought in the sera of 33 patients with endoscopically proved duodenal ulcer and 33 healthy controls. Neither the prevalence nor the antibody levels to both viruses were significantly different between the two groups. These results suggest that herpes viruses may not play a role in the pathogenesis of duodenal ulcer disease.

Adult↗
PubMed1981

Circulating immune complexes in carcinoma of the pancreas.

Circulating immune complexes were detected by the Clq binding assay in 45% of patients with pancreatic carcinoma. 75% of patients with primary biliary cirrhosis and 60% of patients with sclerosing cholangitis. The immune complexes present in most sera from these three groups were not reactive in the Raji cell radioimmune assay or monoclonal rheumatoid factor radioimmunoassay for soluble immune complexes. Thus, it was not possible to differentiate among these diseases on the basis of circulating immune complexes.

Adult↗
PubMed1979

Modification of D-galactosamine-induced liver injury in the rat by spironolactone.

Spironolactone, a competitive inhibitor of mineralocorticoid effects on the distal tubule of the kidney, has recently been found to have other metabolic effects. In these studies, spironolactone (200mg/kg intraperitoneally) for 3 days was found to have a marked protective effect against the hepatotoxic effect of D-galactosamine (275 mg/kg) in rats. Further progress in defining the mechanism of protection from D-galactosamine hepatic necrosis by spironolactone will require assessment of effects of spironolactone on uridine nucleotide metabolism.

Animals↗