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Biomedical subjects

T A Muminov

Publications and source records attributed to T A Muminov.

7 recordsLinked to original sources
PubMed1991

[Decrease in the intensity of luminol-dependent chemiluminescence of neutrophils in patients with pulmonary tuberculosis].

The ability of neutrophils to generate free oxygen forms, and the activity of glutathione-conjugated enzymes and superoxide dismutase were investigated in 94 patients with pulmonary tuberculosis. A drop in the oxygen-generating ability of the patients' neutrophils was revealed. The interrelation between the decrease of activity of antioxidative enzymes and the drop in the oxygen-generating ability of neutrophils are shown. Clinical and pathophysiological importance of the changes revealed is discussed.

Glucosephosphate Dehydrogenase↗
PubMed1991

[The role of precipitating serum antibodies in tuberculosis patients].

The content of serum alpha 1-proteinase inhibitors (alpha 1-PI), alpha 2-macroglobulins, transferrins, albumin, immunoglobulins A, M and G and C3- and C4-complement factors was investigated in a group of patients (n = 35) with pulmonary tuberculosis who showed precipitating antituberculous circulating antibodies having the properties of autoantibodies. A direct relationship between the available circulating antibodies cross-reacting with the tissues and the rate of an extrapulmonary localization of tuberculous process in pulmonary tuberculosis patients, on the one hand, and their inverse relationship to the level of blood alpha 1-PI, on the other, were revealed. It is recommended to define cross-reacting antibodies and alpha 1-PI concentration to predict the risk of extrapulmonary foci of a tuberculous inflammation.

Antibodies, Bacterial↗
PubMed1990

[The oxidative metabolic indices of phagocytizing and immunocompetent cells in patients with pulmonary tuberculosis].

Overall 94 patients with different patterns of pulmonary tuberculosis were examined for glutathione peroxidase (GP), glutathione reductase, glucose 6-phosphate dehydrogenase (G 6-PDH) and superoxide dismutase activity in neutrophils and lymphocytes. Chemiluminescence was used to study the capacity of neutrophils to generate free oxygen forms. Neutrophils showed functional deficiency of GP and G 6-PDH. The decrease of the oxygen-producing capacity of neutrophils, unbalance of glutathione-conjugated enzymes in lymphocytes were revealed either. The role of the alterations enumerated in the reduction of function of phagocytizing and immunocompetent cells in patients with pulmonary tuberculosis is discussed.

Adolescent↗