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Biomedical subjects

T A Nesterova

Publications and source records attributed to T A Nesterova.

7 recordsLinked to original sources
PubMedDate not supplied

[Efficiency of polysaccharide translam for early treatment of acute radiation illness].

Antiradiation therapeutic efficiency of translam (1-->3; 1-->6-beta-D-glucan) produced by enzymatic synthesis out of laminarin, polysaccharide of Laminaria cychorioides, has been studied in four animal species (mice, guinea-pigs, dogs, monkeys). A stable curative effect has been observed following its administration within first 24 h after radiation exposure at doses that cause acute radiation sickness (about LD90). The preparation is nontoxic and has a broad therapeutic range which permits its practical application.

Acute Disease↗
PubMedDate not supplied

[Dependence of the therapeutic effectiveness of interleukin-1beta on the time of the drug administration after irradiation of mice].

In experiments on mice F1(CBA x C57BL/6) the dependence of 30th days survival on the time of betaleukin (medicine form of interleukin-1 beta) administering after exposure to 7.5 Gy whole body gamma-irradiation from 137Cs (approximately DL80/30) was studied. Betaleukin was injected subcutaneously in dose 25 mcg/kg 0.2, 1, 3, 6 and 24 h after the exposure. The highest therapeutic effect took place in case of 0.2 h interval, then it dropped but was slightly expressed at 1 h. The hemopoiesis condition was studied in 7 or 9 days after the mice exposure to 6 Gy and betaleukin administering 1 h later in dose 25 or 50 mcg/kg. The positive effect on granulopoiesis beginning from the level of CFU-GM was observed. There were analyzed the reasons of weaker betaleukin effect and shorter period of its effectiveness after exposure in comparison with literature data regarding IL-1.

Animals↗
PubMedDate not supplied

[Hydroxylating activity of rat liver microsomes in the period of acute phase protein formation in radiation sickness].

At the height of radiation sickness (7-8 days after irradiation) the accretion of proteins of "acute phase" in rat blood was accompanied by diminution of diminution of hydroxylating activity of microsomes determined by the rate of aminopyrine demethylation. There was an invert correlation between these two indices, and the correlation coefficient was -0.9.

Aminopyrine N-Demethylase↗
PubMedDate not supplied

[Experimental study of long-term effects of irradiation on various indices of homeostasis].

Following radiation damage from LD50-LD97, changes in blood, immune and endocrine parameters were revealed and followed up in dogs at the time of late effects development, 3-18 months after exposure. The changes result from post-radiation immunodeficiency and resemble those observed in residents of radioactive contaminated areas or in men participated in Chernobyl accident amelioration.

Animals↗