Biomedical subjects

T A Tomberg

Publications and source records attributed to T A Tomberg.

11 recordsLinked to original sources

PubMed1993

[The use of nimodipine in the acute period of a cerebral infarct].

Before and after intravenous administration of 1-1.5 mg nimotop 18 patients with acute brain infarction underwent EEG, integral body rheography, computed tomography and measurement of regional volumetric cerebral circulation (RVCC). Nimotop appeared to increase RVCC in the infarction zone, especially in low initial RVCC levels. The drug induced a shift to EEG normalization and a hypotensive effect, cerebral hemodynamics remaining without changes. Nimodipine-type calcium antagonists favourably affect brain perfusion and bioelectric activity which is promising for application in acute cerebral infarction.

Acute Disease↗

PubMed1993

[The prognosis of multiple sclerosis: computed tomographic comparisons].

The authors analyze the data obtained at clinical and computed tomography (CT) examinations of 56 patients suffering from multiple sclerosis. The diagnosis was established by G. Schumacher's clinical criteria. Neurologic status of the patients was assessed according to J. E. Kurtzke. A clinical and CT evaluation demonstrates significant correlations between cerebral atrophy and motor insufficiency. Two variants of the disease course are recognized: 1) malignant with emergence of brain atrophy seen at CT as early as the disease year 1; 2) benign with appearance of CT evidence of cerebral atrophy later than the disease year 5. Working ability in variant 2 is recorded for longer periods.

Adult↗

PubMed1989

[Pathologic changes of the brain in children with various forms of infantile cerebral palsy (computerized-tomographic data)].

Based on the clinical and computer-aided correlations a study was made of residual alterations in the brain of 110 children. There were 64 boys and 46 girls with different patterns of infantile cerebral paralysis (ICP). 67% of the examined manifested pathologic alterations on the tomograms (atrophy of the brain of varying intensity, areas of low density, cysts, porencephalia, and dysontogenic phenomena). The rate, character and the site of the pathomorphologic alterations slightly varied with different ICP patterns while the gravest alterations were seen on the computerized tomograms during double hemiplegia, in the hemiparesis and atonically astatic patterns of ICP.

Adolescent↗

PubMed1989

[Clinical and computerized-tomographic correlations in children with cerebral palsy].

Clinical investigation and computed tomography (CT) were performed in 75 children with the infantile cerebral paralysis (ICP). In 63% pathomorphologic changes were found, their rate dependent on ICP form and severity of the motor deficiency. Most frequent finding was ventricular system dilatation which was asymmetrical in majority of patients. Uniform CT changes--frontal atrophy--were found in patients with atonic-astatic form of ICP.

Adolescent↗

PubMed1988

[Effect of calcium antagonists of the verapamil type on regional cerebral blood flow and bioelectric activity of the brain in patients with cerebral infarction].

The authors have studied the regional volume cerebral blood flow (RVCBF) in 25 patients with acute cerebral infarction before and after the intravenous administration of 5-7.5 mg of isoptin and carried out quantitative frequency analysis of the EEG in 20 patients prior to and following the administration of 5 mg of finoptin. It has been revealed that isoptin augments the RVCBF in the infarcted zone, particularly when patients with extensive infarction, edema and atrophy of the cerebral tissue (according to findings of computer-aided tomography) have low baseline levels of the RVCF and somewhat decreases the blood flow in intact zones. The administration of finoptin tended to normalize the EEG, particularly in the infarcted area in patients with a severe clinical picture of infarction. Calcium antagonists of the verapamil type exert a favourable effect on perfusion and bioelectrical activity of the brain; as a result their use is indicated in the patients with acute cerebral infarction.

Action Potentials↗

PubMed1988

[Hyperbaric oxygenation in the treatment of patients with ischemic stroke].

Biochemical parameters (the gaseous composition and acid-base balance of the blood and cerebrospinal fluid (CSF) were investigated in patients with ischemic stroke in the process of hyperbaric oxygenation treatment. A characteristic peculiarity observed was the presence of compensated metabolic acidosis in the CSF which was most expressed in patients with an extensive focus of cerebral infarction. A characteristic change in the venous blood of the brain was the presence of compensated metabolic acidosis. Metabolic acidosis of the cerebral venous blood in patients treated with hyperbaric oxygenation significantly diminished as compared with the control group.

Acid-Base Equilibrium↗

PubMed1988

[Effect of electric stimulation or lesion of the thalamus on cerebral circulation].

Local cerebral blood flow (lCBF) in the thalamus and cerebral cortex was determined in 16 alert rabbits after electric stimulation of thalamic nuclei, and in 22 anesthetized dogs after thermocoagulation of posterior part of the thalamus. The cerebrovascular dilatory effect and increase in the lCBF were observed. Rheoelectroencephalographic investigations in 13 patients with parkinsonism subjected to stereotaxic lesion of thalamic ventrolateral nuclei also showed a diffuse reduction of arterial tone and cerebrovascular resistance. The data obtained seem to explain the reactive hyperemia which may develop primarily as a neurogenic reaction and then be maintained by metabolic changes.

Animals↗

PubMed1987

[Computerized tomographic and clinical examination of children with hemiparesis].

Clinical examination and computerized tomography of 29 children with hemiparesis of different origin and severity (23 with a hemiparetic form of infantile cerebral paralysis and 6 with acquired hemiparesis) revealed in 69 per cent of the patients pathomorphological changes in the brain whose markedness correlated with the severity of the clinical status. The most frequent finding was dilatation of the ventricular system of the brain which was asymmetrical in most cases. Along with the atrophic process some patients presented focal or diffuse changes in the density of the cerebral matter depending on the nature of the primary damaging factors (zones of decreased density, porencephaly, calcification). Specification by computerized tomography of the structure and size of the pathomorphologic alterations in the brain allows evaluation of the clinical prognosis.

Adolescent↗

PubMed1987

[Pharmacodynamic action of cavinton on regional volume blood flow, central hemodynamics and the bioelectric activity of the brain in the acute stage of a cerebral infarct].

Forty-two patients with acute cerebral infarction were studied for the regional volumetric cerebral blood flow (rVCBF) and central hemodynamics (by integral rheography of the body) before and after the intravenous administration of 10 or 20 mg of cavinton (vinpocetine). It was found that in the absence of changes in the central hemodynamics an increase in the cerebral blood flow was the predominant characteristic, but parodoxical reactions were occasionally observed in the acute period of an extensive hemispherical infarct. The findings of quantitative frequency analysis of the EEG conducted in 40 patients correlated with the results of the study of the blood flow and indicated a more favourable prognosis in brain stem infarction or mild cortical infarction. Treatment of extensive cortical infarction was associated with cases of parodoxical deterioration of brain function which should be taken into account in prescribing cavinton to patients during the acute stage of cerebral infarction.

Acute Disease↗

PubMedDate not supplied

[Traumatic cerebral infarct].

The clinical variants of traumatic cerebral infarction (TCI) were studied according to the results of computed tomography. It was found that TCI was encountered in 3.3% of patients with craniocerebral trauma. The localization and mechanism of the development of the ischemic lesion were determined by the character of the traumatic changes in the brain. Compression of the cerebral vessels and reduced perfusion pressure in intracranial three-dimensional processes are important in the pathogenesis of TCI. Computed tomographic studies must be repeated in order to establish the diagnosis of TCI.

Adult↗

PubMedDate not supplied

[The dependence of the function of the sympathetic-adrenal and hypothalamo-hypophyseal-adrenal cortical systems on the severity of the traumatic brain lesion].

A total of 43 males with craniocerebral injury of varying severity were studied for the venous blood plasma levels of adrenaline, noradrenaline, adrenocorticotrophic hormone, and hydrocortisone in dynamics. Their computed tomograms were quantitatively analysed to identify the site of contusion foci in the cerebral hemispheres, especially the lesion signs of mesodiencephalic and truncal regions of the brain. The results of the studies and non-linear regression analysis have shown that brain injury leads to a substantial activation of the body's sympathoadrenal system, extremely severe injury causes its partial reduced performance. In severe and critical cerebrocranial injury, the central link of the hypothalamus-pituitary-adrenocortical system is exhausted and hydrocortisone release occurs without its control. The above changes depend on the size of hepatoma and edema of the cerebral hemispheres and on secondary lesion of the brain mesodiencephalic and truncal regions. The activity of the sympathoadrenal and hypothalamus-pituitary-adrenocortical system, which was observed over a week, tended to its gradual decrease.

Acute Disease↗