Biomedical subjects
T A Valikova
Publications and source records attributed to T A Valikova.
[Lymphocytes with receptors for Streptococcus group A polysaccharide in the thymus of myopathy patients].
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[Mechanisms of DNA repair disorders in human cells. Genome instability in lymphocytes of patients with myopathy related to DNA repair disorders].
Increased level of cytogenetic damages was observed in lymphocytes of 10 patients with muscular dystrophy (Duchenne, Erba, Landuzi--Degerin). Analysis of DNA repair synthesis revealed inhibition of this process in lymphocytes of 10 patients observed. On the other hand, decreased reactivation of vaccinia virus and increased level of virus mutagenesis induced by 4-nitroquinoline-1-oxide and bleomycin was noted in the experiments with lymphocytes of 3 patients observed.
[Myoid cells in the thymus of patients with myopathy].
Immunofluorescence was used to demonstrate that in progressive muscular dystrophy, myoid cells in the patients' thymus undergo profound changes which affect the processes of their formation, differentiation and maturation. Pronounced changes in the myoid cells were disclosed in two forms of myopathy. These changes lie in the increased number of myoid antigens in Erb's myopathy, whereas in Duchenne's myopathy, they manifest in the diminution of the number of myoid antigens in the internal environment of the thymus. It is suggested that the differences in the pattern of changes in the myoid cells, apart from other factors, apparently govern the peculiarity of the pathological process in the two forms of muscular dystrophy.
[Clinical results of thymectomy in myopathy patients depending on the degree of muscular weakness].
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[First experience with the surgical treatment of patients with myopathy].
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