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Biomedical subjects

T A Vasina

Publications and source records attributed to T A Vasina.

At least 19 recordsLinked to original sources
PubMed1998

[Etiotropic antibiotic therapy and immunotherapy of patients with pyo-inflammatory processes].

A 3-year experience was reviewed in the treatment of patients with pyoinflammatory processes (PIP) which developed during the postoperative period in 387 persons with closed injury and multiple penetrating wounds of the chest and stomach complicated by massive hemorrhage. When the PIP was localized in the abdominal cavity, enterobacteria and bacteroides were the main pathogens: 49.4 +/- 2.1 and 32.8 +/- 1.4 per cent, respectively. When the PIP was localized in the thoracic cavity, the most frequent pathogens were staphylococci, Pseudomonas aeruginosa, and enterobacteria: 26.5 +/- 1.4, 24.6 +/- 1.4 and 13.3 +/- 0.8 per cent, respectively. In all the cases high variability of the antibiotic susceptibility of the isolates and predominance of the strains resistant to 5 or more drugs were observed. A suppressive effect of thienam on the immune system was revealed. The immunocorrection in parallel with the antibiotic therapy made it possible to prevent further development of immune deficiency and to recover the bactericidal potency of the phagocyting cells. The use of various physiochemical methods in complex treatment of PIPs is substantiated.

Adult↗
PubMed1996

[Microbiological diagnosis and antibacterial therapy of non spore-forming anaerobic infections in emergencies].

A total of 240 patients with soft tissue and wound suppurations, peritonitis, and suspected sepsis were examined. Anaerobic isolates were more frequently obtained in 20-75% of patients infections associated with facultative microbes. The use of non-culture media (bacterioscopy and gas-liquid chromatography) increased the detection rate of anaerobic infection up to 82% as compared with bacteriological diagnosis (63%). The findings and the data of monitoring of suppuration agents for several years allowed the authors to work out effective combined treatment regimes for early mixed aerobic and anaerobic infections in 80-100% of patients.

Anti-Bacterial Agents↗
PubMed1995

[Microbiologic diagnosis of mixed anaerobic and aerobic surgical infections].

One hundred and twelve patients with purulent affections of the abdominal and thoracic cavities as well as soft tissues and 49 patients with suspected generalization of the infection were examined. It was shown that the position of mixed anaerobic and aerobic infections in various groups of the patients could reach 70-80 per cent while the species composition of the pathogens was close to that of the normal microflora in the affected organ or its region. Bacteroides spp. played the main role in the development of anaerobic sepsis and conditioned a distinctive process. There was observed synergism of Escherichia coli and Staphylococcus spp. and they were shown to serve as indicators of the anaerobic infection due to these species in definite biotops. The use of GLC markedly lowered the time required for diagnosis of anaerobic infections which provided rational chemotherapy at the early stages of the disease with an account of the data on monitoring of the suppuration causative agent.

Bacteria, Aerobic↗
PubMed1995

[Effect of drugs of various groups on the course of experimental local pyo-inflammatory processes].

To develop new approaches to providing higher efficacy of antibacterial therapy of purulent infection, experiments on 104 rats were performed. A decrease in the inflammation was shown in a series of the experiments with the dermonecrotic test using mono- and mixed cultures of Staphylococcus aureuo, Pseudomonas aeruginosa and Escherichia coli at the background of the animal treatment with anapriline and heparin. The effect of mezatone and dicinone was the opposite one. The drugs had different effects on the host response to the introduction of microorganisms of various species as mono- and mixed cultures. The experiments on a group of animals with wound infection not subjected to the preliminary alteration of the tissues demonstrated that the treatment with gentamicin and anapriline combinations was more efficient than the gentamicin monotherapy. The use of anapriline improved the antibiotic pharmacokinetics, had a favourable effect on the wound reparation, promoted a decrease in the count of viable microbes in the wound secretion and increased the antibiotic concentration gradient.

Adrenergic Agents↗
PubMed1991

[Prolonged antibacterial action of polymer coated suture materials].

The antimicrobial activity of capromed, a surgical polymer-coated sutural material containing dioxidine, quinoxidine or gentamicin was studied in vitro and in vivo. Capromed was shown to be active against the hospital strains of S. aureus, E. coli, Proteus spp., Klebsiella spp. and P. aeruginosa. The antimicrobial activity of ADH and AG threads was preserved for 3 to 4 days after implantation. The DH-2 and G-2 threads preserved their activity for 6 to 7 days. It was concluded that the duration of thread antimicrobial activity depended on the properties of the polymer coating the thread. Capromed was applied to 280 operation wounds in 275 patients. There was no wound suppuration in the group of patients after pure operations (n = 62). In the group of patients after conditionally pure operations (n = 130) suppuration was observed in 2 patients (1.3 per cent). In patients with contaminated wounds (n = 88) suppuration in 5 of them (5.7 per cent) was recorded. The total number of the purulent complications after using capromed in surgical operations amounted to 2.5 per cent. In the control group purulent complications were stated in 8.2 per cent of the cases.

Animals↗
PubMed1991

[Prevention of infectious complications in patients with acute bone marrow depression].

Clinical efficacy of intravenous gentamicin in combination with oral use of gentamicin, ristomycin and nystatin was studied in 1977. In 1980-1984 two antiinfectious regimens were tested: intravenous administration of gentamicin in combination with total decontamination (oral use of gentamicin and nystatin) and selective decontamination (biseptol with nystatin of amphoglucamine). It was shown that the incidence of severe infections in the patients under the observation dropped against the controls. The incidence and spectrum of infectious complications in cases with acute myelodepressions were proved to depend on the intestinal autoflora inhibition.

Acute Disease↗
PubMed1991

[The dynamics of the wound microflora in the victims of the earthquake in Armenia].

The data on the composition of wound microflora, as well as changes in the contamination index over the course of treatment of patients with the syndrome of prolonged compression, who were brought to the institute after the earthquake in Armenia, are presented. The authors characterize the structure of the causative agents of wound infection in the patients treated at the traumatological department of the institute over several years. The epidemiological situation in the hospital in the period when the earthquake victims were treated there is analyzed.

Amputation, Traumatic↗
PubMed1991

[The use of ultraviolet-irradiated plasma in the treatment of peritonitis].

Intravenous infusion of the one-group lyophilized donor plasma irradiated with ultraviolet rays was included in the complex treatment of 43 patients with acute purulent peritonitis. The species-specific composition of the microflora was studied in the different groups of patients according to the cause of peritonitis and the degree of microbial contamination of the purulent wounds in patients treated with and without ultraviolet plasma irradiation (UVPI). For prognosticating the course and outcome of the disease the authors used a complex of indices linked with the manifestation of neutrophil bactericidal activity and the level of exogenous intoxication. A positive effect of UVPI in the management of acute purulent appendicitis was noted, which was confirmed by clinical and microbiological tests.

Adolescent↗
PubMed1989

[Treatment of open injuries in the victims of the earthquake in Armenian SSR].

The results of treatment of 36 patients injured during the earthquake in Armenia are analyzed. The patients had severe traumas: open injuries to the limbs, complicated by nephro- and hepatopathies. The periods of the limb crushing with fragments of ruined buildings varied from 3 hours to 3 days. The treatment modalities included conservative and operative detoxication (hemoperfusion, hemodiafiltration, hemofiltration, prolonged endolymphatic infusions of drugs), active surgical strategy, rehabilitation of patients. Seven amputations, 7 reamputations, and 21 necrectomies were performed in 36 patients by vital indications; no lethal outcomes were recorded. Restorative skin plasty was performed in 14 patients with 19 limb stumps, with good functional outcomes. The patients were directed to the Central Research Institute of Prosthetics to be supplied with prostheses. Only in 3 patients with the upper limb crushing the development of stable ischemic contractures could not be prevented.

Amputation Stumps↗
PubMed1989

[Preventing incompetence of uterine sutures after cesarean section].

Antimicrobial polymer films were used at cesarean section in 81 patients. The method is described, and the results are reported. Pharmacokinetic and microbiologic studies, and the immediate assessment of postoperative uterine contractility as well as late assessment of the uterine scar have demonstrated that polymer materials, used in patients at high risk for postoperative complications do not interfere with postpartum uterine contraction and are an effective means of preventing uterinescar incompetence.

Adult↗