Biomedical subjects

T Aamodt

Publications and source records attributed to T Aamodt.

8 recordsLinked to original sources

PubMed1988

Effects of withdrawal of sustained-release theophylline in patients with chronic obstructive lung disease.

In a double-blind, cross-over study, sustained-release theophylline was withdrawn to determine whether the drug was still effective after long-term treatment. Twenty adult out-patients with stable, chronic obstructive lung disease and who had been on continuous long-term treatment for at least 6 months, were studied. Lung function, plasma theophylline concentration, symptom score, number of nocturnal dyspnoea attacks, requirement for additional beta 2-stimulant aerosol, and side effects, were recorded before withdrawal, after withdrawal and after reinstitution of treatment. When theophylline was withdrawn, all parameters were significantly worsened, but after reinstitution of treatment they all improved significantly. The results show that sustained-release theophylline remains effective after at least 6 months' continuous treatment in adult patients.

Adult↗

PubMed1986

A case-referent study of lung cancer, occupational exposures and smoking. II. Role of asbestos exposure.

In a hospital-based case-referent study of 176 incident lung cancer cases, ascertained during a five-year period from two county hospitals, the role of asbestos exposure and smoking has been studied. Information on asbestos exposure was obtained from personal interviews, and allocated to four exposure categories, according to the intensity and duration of the exposure. Twenty-five percent of the cases and 10% of the referents had been moderately to heavily exposed to asbestos during their working career. A statistically significant trend in risk ratio related to the degree of exposure was observed, with a more than fourfold risk among the heavily exposed. The strongest association was found between asbestos exposure and small cell carcinoma, and the weakest association between asbestos exposure and adenocarcinoma. Very high risk ratios were observed among asbestos-exposed subjects who were heavy smokers, and the interaction observed between asbestos and smoking conformed more closely to a multiplicative model than to an additive one. The results suggest that the observed association between lung cancer and occupational exposures in this study was, to a large extent, due to asbestos exposure. Information on such exposure was missing in 90% of the medical records of these patients.

Adult↗

PubMed1986

A case-referent study of lung cancer, occupational exposures and smoking. I. Comparison of title-based and exposure-based occupational information.

The role of occupational exposures and smoking in the development of lung cancer has been studied among 176 male incident lung cancer cases and 176 referents admitted to two county hospitals in southeast Norway during 1979-1983. After the allocation of all occupational titles in the Nordic Classification of Occupations into three exposure groups according to potential exposure to respiratory carcinogens and other contaminants, each subject was classified according to exposure status of main occupation and number of years in each exposure category. An excess risk of lung cancer was observed both among those in possibly exposed occupations and among those definitely exposed. A more than threefold excess risk was observed among subjects with more than 30 years in exposed occupations. Exposure to 22 agents/processes was further assessed by a separate questionnaire and estimated simultaneously in a logistic regression model. Elevated risks were associated with exposure to asbestos and several other agents/processes, which largely correlated to each other. Smoking was strongly associated with all histological subtypes of lung cancer, while for occupational exposures the risk ratio was highest for small cell carcinoma and lowest for adenocarcinoma. Very high risk ratios for lung cancer were observed among heavy smokers in exposed occupations.

Adult↗

PubMed1985