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PubMed1997

[Integrated psychiatric care planning].

In order to design an integrated plan for services, all long-term psychiatric patients in Trondheim were registered by professionals on both municipality and county level. Data were obtained from interviews with the patients, supplemented by information from professional personnel. Individual plans, including type and amount of services needed, were prepared for each patient anonymously, to form the basis of a mutually beneficial integrated plan for psychiatric services. A total of 507 patients were registered (0.5% of the population over 18 years). Studying individual patients and their needs makes it possible to make optimal use of limited resources. The sharing of knowledge improves cooperation and coordination, to the benefit of a neglected group of patients.

Adult↗

PubMed1988

Single and multiple dose pharmacokinetics of tenoxicam in the elderly.

Fourteen elderly subjects (10 women, 4 men) with a mean age of 81 (SD 6.7) years and in need of anti-inflammatory drug treatment were given a single dose of 20 mg tenoxicam. After a drug-free interval of 5 weeks, multiple dose treatment with 20 mg tenoxicam once daily for 56 days was initiated. The single and multiple dose kinetics of tenoxicam were investigated after HPLC determination of tenoxicam in the plasma. The elimination half-life of tenoxicam ranged from 44 to 132 h (mean 71.9 h) with no significant difference between the single and multiple dosage regimens. Tenoxicam reached maximum plasma concentrations after 1.4 and 1.1 h, with values of 3.6 and 15.5 micrograms.ml-1, for the single and multiple dosage regimen respectively. The corresponding trough values (24-h values) were 1.8 and 11.7 micrograms.ml-1. A mean accumulation ratio of 5.1 was calculated. The mean increase in the area under the plasma concentration time curves at steady-state was 21% more than predicted from the initial single dose. This deviation from linearity was considered to be of minor clinical significance. The kinetics of tenoxicam in elderly were similar to that published for young healthy volunteers.

Aged↗