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Biomedical subjects

T Amano

Publications and source records attributed to T Amano.

At least 19 recordsLinked to original sources
PubMed1979

Prostaglandin D2, a neuromodulator.

The distribution of prostaglandin D synthetase activity was determined in various tissues of rat by using the supernatant fraction (10,000 x g, 20 min) of the homogenates. The highest activity was found in brain, spinal cord, and alimentary tract. The activity was uniquitously distributed in all parts of brain, and the highest specific activity was found in hypothalamus and thalamus. Homogenates of two neuroblastoma cell lines were found to produce prostaglandin D2, whereas a glioma cell line was almost inactive. Prostaglandin D2 is a potent and specific activator of the adenylate cyclase system of cultured neuroblastoma cells, suggesting the possibility that it may act as a neuromodulator in the central nervous system.

Animals↗
PubMed1979

[The range of joint motions of the extremities in healthy Japanese people--the difference according to the age (author's transl)].

The passive range of motion was measured in the shoulder, elbow, forearm, wrist, hip, knee and ankle joints in 624 healthy Japanese persons ranging from the neonatal to 80 years of age, by the method formally decided by the Japanese Orthopaedic Association and the Japanese Association of Rehabilitation Medicine in 1974, followed by a statistical analysis. 1. The joint motions, the range of motion value of which being remarkably different by age, were found among the movements in external rotation and horizontal abduction of the shoulder, extension, abduction, adduction, external rotation, internal rotation of the hip and dorsiflexion of the ankle. 2. Elbow flexion, forearm pronation and supination, wrist dorsiflexion and knee flexion showed little change by age. 3. Extension, external rotation and horizontal abduction of the shoulder, dorsiflexion of the wrist, flexion of the hip, flexion of the knee and dorsiflexion and plantar flexion of the ankle gave values exceeding the normal range indicated by the associations. 4. The fluctuation in the range of joint motion was especially wide in the infant and the aged person.

Adolescent↗
PubMed1979

Immunological unresponsiveness in mice. II. Cellular basis of immunological unresponsiveness induced in foetal and neonatal mice by transfer of human gamma-globulin by the maternal route.

The cellular basis of the mechanism of immunological tolerance to human gamma-globulin (H gamma G) induced in foetal and neonatal mice by materno-foetal or materno-neonatal transfer after a single injection of tolerogen (deaggregated H gamma G) into the mothers was investigated using a cell transfer system and assays of passive haemagglutinating antibodies and plaque-forming cells to H gamma G. The results demonstrated that B cells are mainly involved in the tolerance induced on the fourteenth day of gestation, whereas inactivation of T cells may account for the tolerance induced on the eighteenth day of gestation and in the neonatal stage. Treatment of the mothers with tolerogen and then anti-H gamma G serum reduced the tolerance induced on the fourteenth day of gestation, but did not affect that induced on the eighteenth day of gestation and in the neonatal stage. Cell transfer experiments showed that B-cell tolerance induced on the fourteenth day of gestation was prevented by passive antibody, while T-cell tolerance induced on the eighteenth day of gestation and in the neonatal stage was not affected by passive antibody. Assay of the anti-DNP antibody response after immunization with DNP10-H gamma G showed that treatment of mice with the tolerogen on the eighteenth day of gestation, but not the fourteenth day of gestation, inactivated H gamma G-reactive helper cells. The significance of these results is discussed in relation to the results of the cell transfer experiments described as above.

Animals↗
PubMed1978

A change in membrane microviscosity of mouse neuroblastoma cells in association with morphological differentiation.

Changes in membrane microviscosity as well as in membrane constituents of mouse neuroblastoma clone N-18 were studied in association with neurite formation. The membrane microviscosity studied by fluorescence technique increased with the formation of neurites. The concomitant increase increase in the ratio of cholesterol to phospholipids was also observed.

Anilino Naphthalenesulfonates↗
PubMed1978

Surgical treatment of renovascular hypertension associated with bilateral renal artery stenosis.

We report on 15 patients operated upon for renovascular hypertension associated with bilateral renal artery stenosis. Followup has been for 1 to 12 years. Four of 5 patients with positive split renal function studies and 3 of 5 patients with positive renal vein renin assays underwent unilateral operations on the positive side. All of these patients were cured or improved. The guide for unilateral operations in hypertensive patients with bilateral renal artery stenosis by angiography was the physiological information obtained from the preoperative screening tests, especially the plasma renin activity ratios of the 3 different veins and the split renal function studies.

Clinical Enzyme Tests↗
PubMed1978

Hand orthosis for various finger impairments--the K U finger splint.

The K U (Kumamoto University) finger splint has been manufactured for the purpose of developing an effective hand orthosis for various finger impairments using simple parts and materials. By combining the W type orthosis for which piano wire is mostly used, and the S type for which fishing line is mainly used, it has been used to good effect on patients with several kinds of finger impairments. The fabrication and adjustment of the orthosis is simple and if the material is in kit form, a doctor or an occupational therapist can at once construct one and give it to a patient. For this reason, the patient will not lose the chance of timely treatment.

Fingers↗
PubMed1978

Photoelectric method for estimating hemodynamic changes in regional cerebral tissue.

A new photoelectric method for measuring hemodynamic changes in a thin layer of cerebral tissue in situ is described. The apparatus consists of a miniature lamp of 0.7 mm OD and a photodiode with a color filter having maximum light transmission at 548 nm. The lamp was chronically or acutely implanted into the brain tissue of animals as a light source, and the intensity of the light transmitted through the cerebral tissue was monitored with the photodiode from the brain surface. The intensity of the transmitted light was quantified for cerebral blood volume (CBV). The mean transit time of blood (t) was obtained from tissue hemodilution curves produced by saline injection into the carotid artery. The regional blood flow was calculated from the values of CBV and t according to the Stewart-Hamilton equation. The apparatus was shown to be stable, rapid in response, easy to operate, and to give reproducible results. Possible sources of error are discussed.

Animals↗