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Biomedical subjects

T Andreev

Publications and source records attributed to T Andreev.

At least 19 recordsLinked to original sources
PubMed1990

[Triggering bacterial infections in reactive arthritis].

108 patients, 75 men and 33 women, mean age 35 years, with reactive arthritis were studied by microbiological and serological methods for identification of a probable triggering infection. In 32 of the patients a Chlamydia infection, in 30 patients--Yersinia infection, in 7 patients--Staphylococcus infection and in 4 patients--Shigella infection were found. In 27 patients no infectious agent was found but in 4 of them a positive CBR for chlamydia in the sex partner was found. The course of the arthritis is acute or subacute, oligo- or polyarthritis, involving mainly the large joints of the legs. The clinical picture of the arthritis is similar for all etiological forms. This implies a systematic microbiological and serological examination of the patients in order to find out the triggering infection and its appropriate treatment with antibiotics.

Arthritis, Infectious↗
PubMed1989

[Diagnostic potentials of quantitative bone scintigraphy in spondylitis ankylopoietica: a comparison with x-ray findings].

In 576 patients quantitative scintigraphy of the sacroiliac joints and the spinal cord with 99mTc-Pyrophosphate was performed. 328 were patients with proven ankylosing spondylitis according to the New-York criteria. 120 were patients with a clinically and roentgenologically suspected ankylosing spondylitis and 128 persons formed a healthy control group. The count rate in small regions of interest (ROI) in the sacroiliac joints, the spinal cord and the os sacrum were compared on the basis of indexes. The scintigraphic data of patients with ankylosing spondylitis were compared with healthy control group and with the radiographic findings and radiologic staging of the disease: In a longitudinal follow-up study during 1 to 6 years these investigations were continued together with clinical and roentgenological checks. Quantitative bone scintigraphy provides characteristic indexes for ankylosing spondylitis, indicating the increased mineral metabolism of the sacroiliac joints and the spinal chord. Skeletal scintigraphy is recommended for early detection and monitoring of ankylosing spondylitis.

Diphosphates↗
PubMed1988

[The survival of patients with systemic lupus erythematosus].

146 patients with systemic lupus erythematodes were followed up. The patients are classified into two groups: I group--includes 74 patients treated during the 1953-1980. II group--of 72 patients treated during the period 1980-1987. Of the 74 patients of the I group 38 (51%) are still alive and 38 patients (49%) have died. From the II group 67 (93%) are alive and only 5 patients (7%) have died. 56% of the deceased patients died during the first 5 years. The following 5 years the death rate is twice as small--II dead patients (27%). Only 3 patients survived more than 15 years. The leading causes of death are: lupus nephropathy--18 patients (44%), cardiovascular lesions--12 patients (30%), neurologic complications and lately--infectious complications. A correlation between age and evolution of the disease is found: in younger age the evolution is more rapid. The analysis of the treatment of the patients from the II group reveals that the longer survival is due to the correct application of antimalarial drugs, cortisone drugs, imuran, pylse therapy with cortisone or a combination of these drugs.

Adult↗
PubMed1987

[HLA B27-negative forms of Bechterew's disease].

For an 8 year period 45 patients with Bechterew's disease were found who had no antigen HLA-B27. 35 of the patients were tested for HLA--A, -B or -C. In 12 patients antigens of the cross-reacting group B27 (B7, Bw22 and B40) were found. In patients without psoriasis antigens B13, B16, B17 which are known to be related to psoriasis vulgaris were found. 9 patients were antigen Cw2 carriers which is in unbalanced linkage with B27. The B27 negative forms present several clinical features: late onset of the disease, slow and favourable course, development of spinal forms only, lack of iridocyclitis and heart lesions.

Adult↗
PubMed1987

[Study of the HLA system in rheumatoid arthritis].

A statistically significant, after correction of P value, increased incidence of the antigen HLA-DR4 chi 2 = 32.81, p less than 0.001, was established in the comparison of the antigen incidence of HLA-A, B, C and DR antigens in 59 patients with classical and positive rheumatoid arthritis and control healthy subjects. No essential difference in the distribution of DR4 was established that depended on sex, age of occurrence of the disease, presence of rheumatoid factor and the form of the disease.

Adult↗
PubMed1985

[Comparison of x-ray and radionuclide studies of the joints in patients with Touraine-Solente-Golé syndrome].

The thesis of primariness of the disease and of its osseous tissue manifestations is discussed on the grounds of the results from a complex study on 3 patients. The periosteal ossifying hyperplasia and disturbances in the osseous tissue structure develop with no other organ symptomatics and in the absence of any changes in the available laboratory and immunological indices. The macromorphological X-ray characteristic corresponds to the radionuclide tests of the study with 99MTc-pertechnetate, 99MTc-pyrophosphate and 99MTc-sulfocolloid, informing about abnormal vascularization index, growth of bone-marrow tissue and intensified joint-tissue anabolism.

Adult↗
PubMed1982

[Seronegative, HLA-B27-positive arthritis (a preliminary report)].

Fifty two patients, 29 males and 23 females, with seronegative polyarthritis, carriers of tissue-compatible antigen HLA--B27 manifested characteristic clinical signs: the disease started at young age--29; it progresses, most frequently, with attacks--acute or subacute as monoarthritis (gonitis) or oligoarthritis, the lower limb joints predominantly involved. The periarticular structures are very often involved in the process--achillitis, styloiditis, talagia and sarcoiliac joints--sarcoiliitis clinically and scintigraphically confirmed. With the family examinations of the patients' relatives the following cases were established: 9 cases with Bechterew's disease, four cases with sacroiliitis, one--with iridocyclitis, two patients with rheumatoid arthritis and 18 healthy carriers of HLA--B27 antigen. The dynamics of the development of typical ankylozing spondylitus was a favourable prognosis and the treatment, most often, covers--nonsteroid anti-inflammatory drugs or low doses of corticosteroids--generally or locally.

Adult↗
PubMed1978

[Aseptic bone necrosis in lupus disease].

Seven cases with aseptic necrosis in lupus disseminatus are presented being 9.70 per cent of 72 patients with confirmed systemic lupus, observed in the cours of 20 years. Six cases with lupus disseminatus are concerned--acute and subacute paroxysm a course and one case with chronic skin form--discoid lupus, complicated in the course of its evolution with aseptic necrosis of the right head of the femur. The cause for detection of the bone lesions in the cases presented, was the pain, especially manifested with the necrosis localized in the supporting bones of the lower limbs. The analysis of the state of the patients with systemic lupus reveals that all cases, are severe forms of the disease with multiorgan involvement, febrile reactions and the presence of vascular phenomena--Raynaud syndrome, coronary and cerebral arteriitis. High doses of corticosteroid preparations were used in the treatment of the disease due to its lasting progress (paroxysms of 8--12 months).

Adrenal Cortex Hormones↗
PubMed1975

[Treatment of rheumatoid arthritis with a preparation of Sanokrizin--intravenous administration].

Treatment with the preparation "Sanokrizin", applied i. v. has been carried out to 50 patients with rheumatoid polyarthritis--32 seropositive and 18 seronegative forms, being with a duration of the morbid process from one to 17 years. Therapeutic effect was obtained in 78 per cent of the cases, followed up from six months to one year while that therapy proved to be without effect in 22 per cent of the patients or only separate symptoms of the inflammatory process were partially affected. The preparation has a good tolerance and the side-effects, in the absence of controlled auremia, are overcome with discontinuation of the carried out treatment and only to two of the patients corticosteroids were given additionally. With an average dose, per course, of 1751,60 mg effect was also obtained upon single symptoms of the rheumatoid inflammation. The patients, effected at the earliest in the course of the therapeutic process, are with the best and most durable therapeutic effect and that might be used as a prognostic criterion for the favourable effect of the carried out treatment with the preparation "Sanokrizin".

Adolescent↗