Morphological changes in the liver of rats treated with a new hypolipidemic agent, S-8527.
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Administration, Oral↗
Biomedical subjects
T Anzai
Publications and source records attributed to T Anzai.
Age-related change of masticatory function in complete denture wearers: evaluation by a sieving method with peanuts and a food intake questionnaire method.
Age-related changes in masticatory function were investigated in complete denture wearers. The sieving method using peanuts as a test food was compared with the result obtained using a food questionnaire for evaluation of masticatory function. In relationship to aging, both the masticatory performance and the chewing score decreased significantly (the masticatory performance: r = .60, P < .01; the mastication score: r = -.46, P < .05). It is suggested that the masticatory function in complete denture wearers decreases in relationship to aging. The food intake questionnaire is useful for evaluating masticatory function in complete denture wearers.
Age Factors↗
The application of phenoxybenzamine in open heart surgery using cardiopulmonary bypass.
The effects of vasodilator therapy upon organ blood flow, beta-glucuronidase activity in plasma and pulmonary surfactant were evaluated before and during cardiopulmonary bypass. Alpha adrenergic blockade with phenoxybenzamine increased the organ blood flow in the heart, brain, stomach, small intestine, large intestine, and liver, whereas it decreased the organ blood flow in the kidney, spleen, and lung. These changes were extremely similar to those observed at hemorrhagic shock. With 2 mg/kg of POB the organ blood flow tended to approach to control levels. The increase of beta-glucuronidase activity at hemorrhagic shock was considerably inhibited after intravenous drip of 2 mg/kg of phenoxybenzamine. We examined the changes of pulmonary surfactant biochemically. Pulmonary surfactant was decreased in endotoxin shock and similar changes were observed in cardiopulmonary bypass when perfusion time was extended to 3 hours. The decrease of pulmonary surfactant after bypass was inhibited by application of POB. From these results, we supposed that the circulatory dynamics during cardiopulmonary bypass might be similar to that of shock and the application of POB in cardiopulmonary bypass might be useful. We applied POB clinically and had good results.
Animals↗