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Biomedical subjects

T Asada

Publications and source records attributed to T Asada.

At least 109 records · Page 6Linked to original sources
PubMed1993

[Surgical treatment of left atrial myxoma with coronary arterial lesion].

We experienced two patients of left atrial myxoma with coronary arterial lesion. One patient, who was a 52-year-old female, was transferred to our institute with the diagnosis of acute myocardial infarction. The coronary angiogram showed an abrupt 99% stenosis of posterolateral branch of circumflex artery with no atherosclerotic lesion, and the echocardiography revealed a left atrial myxoma disturbing the blood flow across the mitral valve. She was in congestive heart failure with pulmonary hypertension, and underwent an emergency removal of the myxoma under cardiopulmonary bypass. Another patient, who was a 70-year-old male, was admitted to our institute with the chief complaint of chest pain. The coronary angiogram showed an 75% atherosclerotic stenosis of the right coronary artery, and the echocardiography revealed the left atrial myxoma. He received a removal of myxoma and a coronary artery bypass grafting simultaneously. These 2 patients went a good postoperative course and live a lively life with no local recurrence. In this paper, the surgical treatment of left atrial myxoma with coronary arterial lesion was reviewed.

Aged↗
PubMed1993

[Surgical treatment for true aneurysm of the deep femoral artery, and a review of literatures in Japan].

A true aneurysm of the deep femoral artery is very rare among peripheral aneurysms because of its anatomical position and characteristics of wall tissue. An early operation is mandatory because it has a tendency to become a large size and to rupture. During the last eight years, we experienced two cases. One ruptured case underwent only resection of aneurysm and another case received an additional reconstruction of deep femoral artery using saphenous vein graft. Both of them are doing well postoperatively. In this paper, a review of 24 cases including these two in Japanese literature was discussed.

Aged↗
PubMed1993

[Medtronic model 6500 temporary myocardial pacing lead: a report of clinical assessment until three weeks after cardiac surgery].

Medtronic model 6500 heart wire as a right ventricular electrode was assessed in 41 postoperative cases. R-wave amplitude, slew rate, peak-to-peak, output, current, and resistance were measured by Medtronic A-V pacing system analyser, model 5311, for three weeks after open heart surgery. These parameter changed until the 7 th postoperative day, but did not change significantly thereafter. Output and current did not exceed beyond 10 V and 20 mA respectively, where there is limitations of usually available pacemaker. No complication was encountered. These results showed that this heart wire was reliably useful even until 3 weeks after open heart surgery.

Adolescent↗
PubMed1993

[Surgical treatment of thoracic and thoracoabdominal aneurysm during partial cardiopulmonary bypass].

We operated on 3 patients with thoracic or thoracoabdominal aneurysm using partial cardiopulmonary bypass with right atrial drainage. The first patient was in the preshock state with severe chest and back pain. The aortography and enhanced computed tomography showed a thoracic aneurysm of 70 mm in maximum diameter ruptured into the extrapleural space and an emergency surgery was performed. The second patient was also in the preshock state with chest and back pain. The enhanced computed tomography showed a thoracoabdominal aneurysm of 120 mm in maximum diameter ruptured into the bilateral pleural spaces and an emergency surgery was performed. The third patient had a thoracoabdominal aneurysm of 60 mm in maximum diameter with a low pulmonary function. In all 3 cases, a perfusion cannula was inserted in the femoral artery and a drainage cannula was placed in the right atrium through the femoral vein. In the first case, an additional perfusion cannula was inserted into the axillary artery in order to secure the cerebral flow even at the time of intraoperative massive bleeding from the aneurysm. In all 3 cases, the approach for aneurysm was through spiral incision and aneurysms were replaced by graft inclusion technique. All 3 patients had an uneventful postoperative course and are doing well. In surgical treatment of thoracic and thoracoabdominal aneurysm, usefulness of partial cardiopulmonary bypass using right atrial drainage was discussed.

Aged↗
PubMed1993

[Surgical treatment of ruptured sinus of Valsalva aneurysm].

We operated on 3 patients with ruptured sinus of Valsalva aneurysm (RSVA). According to the classification by Konno, 2 of them had type I RSVA where aneurysm originated from the right coronary sinus rupturing into the right ventricle, and another type IV where it arose from the non-coronary sinus draining into the right atrium. Both of the 2 with type I RSVA had accompanied ventricular septal defect (VSD) of Kirklin type I. One of them had infective endocarditis with vegetations clinging to the aortic valve, the pulmonary valve and the right ventricular wall adjacent to VSD, and aortic regurgitation of grade II consequently occurred. In this patient, the aortic cusps and the wall of sinus of Valsalva aneurysm were taken out with vegetations. The defect of sinus and VSD were closed with one large patch and a 25 mm SJM aortic valve was implanted using the patch as a part of annulus. The other patient with type I RSVA received a direct closure of defect of Valsalva sinus and VSD. Another patient with type IV RSVA underwent a direct closure of right atrial wall where aneurysm protruded. All 3 patients are doing well without shunt and aortic regurgitation. In this paper, diagnosis, surgical treatment and outcome of RSVA were reviewed.

Adult↗
PubMed1993

[Surgical treatment of left atrial myxoma with concomitant acquired heart disease].

Among 21 patients with left atrial myxoma treated during the past 11 years in our institute, 3 patients had associated acquired heart disease which required concomitant cardiac surgery. Two patients had atherosclerotic coronary arterial disease, and underwent single coronary artery bypass grafting (CABG) and 4 CABGs in addition to removal of myxoma, respectively. Both of them received CABGs after removal of myxoma, because the intraoperative heart protection using retrograde coronary perfusion could afford the situation. Another patient had a huge left atrial myxoma associated with mitral and tricuspid regurgitation. She suffered from sudden heart failure caused by tumor obstruction of blood flow across the mitral valve, and an emergency surgery was performed. She underwent mitral valve replacement for annular dilatation with prolapse of both leaflets and tricuspid annuloplasty for annular dilatation, in addition to removal of myxoma. All of these 3 patients went a good postoperative course and are doing well now with no local recurrence. In this paper, preoperative and intraoperative evaluation, and surgical treatment of associated heart disease with left atrial myxoma were discussed.

Aged↗
PubMed1992

Severe hypoxia due to ventilation-perfusion mismatch caused by aortic arch aneurysm.

We report a very rare case of hugh aortic arch aneurysm associated with aortic restenosis, which caused severe hypoxia due to ventilation-perfusion mismatch by compression of the left main bronchus and the right pulmonary artery. Aortic arch replacement was performed under circulatory arrest and deep hypothermia in addition to aortic valve replacement as a redo operation, and consequently such hypoxia was relieved.

Adult↗
PubMed1992

[Efficacy of nicorandil on myocardial protection during coronary artery bypass grafting--a comparison with diltiazem].

Diltiazem (DTZ), a calcium slow channel blocker, is estimated to be highly effective for myocardial protection and the prevention of perioperative coronary spasms (PCS). However, the use of high doses of DTZ sometimes results in difficulty in coming off cardiopulmonary bypass due to negative chronotropic activity. Nicorandil (NCD) has remarkable coronary vasodilating effect but possesses little negative chronotropic activity. The purpose of this study was to compare NCD with DTZ with respect to effect on myocardial protection during coronary artery bypass grafting (CABG). As parameters, excess lactate (delta XL), redox potential (delta Eh), left and right ventricular stroke work indices (LVSWI, RVSWI), cardiac index (C.I.), systemic vascular resistance index (SVRI.), myocardial isoenzymes (CK-MB, LDH1), number of PCS and recovery time of chronotropic action were used. delta XL, delta Eh, LVSWI, RVSWI, C.I., SVRI, CK-MB, LDH1 were measured at 0, 1, 3, 6, 9, 18 and 24 hours after the removal of aortic cross clamping. The degree of chronotropic action was evaluated by the length of the recovery time to self beat or normal sinus rhythm after the removal of aortic cross clamping. Forty patients who underwent CABG with retrograde cold blood cardioplegia between Dec. 1989 and May 1991 were divided into the NCD group (n = 20), in which 1.1 micrograms/kg/min NCD was continuously administered from the beginning of the operation and the DTZ group (n = 20), in which the initial St. Thomas cardioplegia containing 5 mg/L and subsequent cold blood cardioplegia solution contained DTZ 3.5 mg/L, for a total DTZ dose of less than 10 mg.(ABSTRACT TRUNCATED AT 250 WORDS)

Cardioplegic Solutions↗
PubMed1992

[Ischemic cardiomyopathy associated with ischemic mitral regurgitation--a case report of successful repair].

We experienced a case of 62-year-old man with ischemic cardiomyopathy and mitral regurgitation. He had a heart failure of New York Heart Association class IV together with unstable angina. His further examination showed an enlarged left ventricle with markedly reduced ejection fraction (12.9%) and ischemic mitral regurgitation of grade III associated with 3-vessel disease. He underwent three coronary artery bypass graftings and mitral annuloplasty by a modification of Kay's method. He showed a remarkable improvement of heart failure and cardiac function together with a disappearance of mitral regurgitation. He discharged from hospital in NYHA class II on the 50th postoperative day and lives an almost normal life now. Operative indication and management of ischemic cardiomyopathy and mitral regurgitation were discussed.

Coronary Artery Bypass↗
PubMed1992

[Evaluation of platelet aggregation test by grading curve].

In order to standardize the platelet aggregation test, we used the grading curve (GC) produced by plotting four concentrations (0.5, 1.0, 2.0 and 4.0 microM) of ADP and four concentrations (0.25, 0.5, 1.0 and 2.0 micrograms/ml) of collagen, which are aggregation inducers, along the horizontal axis and plotting their individual rates (%) of aggregation 5 minutes after administration, along the longitudinal axis. The degree of platelet aggregation was classified in 6 stages (Types III, II, I, 0, -I and -II), ranging from marked increase to marked decrease, according to the GC of ADP aggregation in healthy subjects. Type I or 0 ADP aggregation was observed in 78% of the subjects, and Type I collagen aggregation was observed in about 50% of the subjects, whereas patients with cerebral infarction showed distinct increases in Type III and II aggregations of both ADP and collagen. In most patients who were treated with antiplatelet drugs, the aggregation were Type 0, -I or -II. The concentration of inducer, which corresponded to the maximum 50% value of the GC (Max 50) was significantly correlated with the minimum concentration (threshold concentration) in ADP aggregation, at which secondary aggregation was induced even if it was reversible, and with the minimum concentration (threshold concentration) in collagen aggregation, at which the aggregation rate 5 minutes after administration increased to 50% or higher. The GC of platelet aggregation seemed to enable easy determination of the degree of aggregation, and was also considered to be useful for monitoring platelet aggregation during the administration of antiplatelet drugs.

Adult↗
PubMed1992

[Surgical treatment of primary cardiac tumors].

Twenty patients with primary cardiac tumors were operated on during the past ten years. The age of 15 female and 5 male patients ranged from 17 to 73 years. Eighteen patients had myxomas, 16 of which located in the left atrium and 2 in the right atrium. Systemic embolism occurred in 8 patients, subsequently caused cerebral infarction in 4, ischemia of extremities in 2, myocardial infarction in 1 and pulmonary infarction in 1. Emergency operation was performed in 5 patients because of severe congestive heart failure. In all cases, removal of myxoma was performed together with the excision of the wall to which the pedicle attached with the use of cardiopulmonary bypass. One patient with pulmonary infarction underwent resection of the infarcted lung simultaneously. Only one patient with severe heart failure died of pulmonary insufficiency one month after the operation. Another patient with cerebral infarction underwent clipping of cerebral aneurysm which appeared later in the infarcted area. The 17 patients including the latter patient showed a good recovery and no local recurrence during the follow-up period of 1 to 120 months. Two patients had malignant tumors, which were malignant fibrous histiocytoma of the left atrium and leiomyosarcoma of the pulmonary artery, respectively. Both of these rare tumors were resected noncuratively and led to the death because of their local recurrence with distant metastasis, though they received adjuvant chemotherapy. The symptoms, complications, diagnoses, surgical treatment and outcome of the primary cardiac tumors are reviewed in this study.

Adolescent↗
PubMed1992

[Coronary artery bypass surgery in patients with severely impaired left ventricular function].

The efficacy and problem of coronary artery bypass grafting (CABG) in patients with severely impaired left ventricular function (left ventricular ejection fraction < or = 30%) were assessed in 27 patients of whom 17 (group 1) underwent emergent CABG and 10 (group 2) elective between Jan 1984 to Aug 1990. As a whole, history of myocardial infarction (24/27, 88.9%), large left ventricular volume with reduced ejection fraction (LVEDVI 126.08 +/- 25.91 ml/m2, LVESVI 93.04 +/- 21.02 ml/m2, LVEF 25.04 +/- 4.75%) and multiple vessel disease with at least one vessel total occlusion (20/27, 74.1%) were characteristically seen in these patients. The patients of group 1 were significantly older (mean 66.12 +/- 5.68 vs 57.10 +/- 8.08, p < 0.01) and needed more frequent preoperative support with IABP (17/17 vs 4/10, p < 0.01). Using Thallium-201 scintigraphy, in 10 patients of group 1 and 9 of group 2, myocardial viability in the proposed bypass area was evaluated before operations. Average 2.37 +/- 0.79 grafts were placed and continuous retrograde cold blood cardioplegia via the coronary sinus was employed for myocardial protection. Two mitral annuloplasty (MAP) for ischemic mitral regurgitation and 2 cryoablation for the treatment of ventricular tachycardia were performed concomitantly. Operative mortality was 47.1% in group 1 and none in group 2 (p < 0.05). Two cases of MAP died, but two cases of cryoablation survived. Postoperative LVEF was improved significantly only in group 2 (p < 0.05), but during the follow-up period of 7 months to 6 years, all 19 survivors expect one remains with NYHA class I or II.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1992

[Postoperative conduction disturbances in patients with retrograde continuous cold blood cardioplegia].

Two hundred twenty-seven patients who underwent open heart surgery with retrograde continuous cold blood cardioplegia (RC-CBCP) were investigated to manifest the incidence of postoperative conduction disturbances (CD) and to determine factors related to the occurrence of CD. The incidence of CD in patients with RC-CBCP was 16.7%, which was lower than that (24.4%) in 41 patients with antegrade continuous cold blood cardioplegia. In addition, the CD resolved by the time of hospital discharge in 65% of the patients. There were no patients with new complete atrioventricular block requiring a pacemaker. The development of postoperative CD was related to topical cooling with slushed ice and lower myocardial temperature of the left ventricle, but not to kinds of diseases, duration of aortic cross-clamp, or the distribution of RC-CBCP evaluated from myocardial temperature at the end of initial infusion of cold cardioplegic solution. Furthermore, terminal warm blood cardioplegia reduced the occurrence of CD. We conclude that the occurrence of CD in patients with RC-CBCP is lower than that in patients with antegrade cardioplegia, and is most related to local hypothermia with slushed ice. This suggests that the most likely mechanism for the development of CD would be ischemic or reperfusion injury to the specialized conduction system with the disturbance of microcirculation because of rouleaux formation in CBCP at very low myocardial temperature.

Aged↗
PubMed1992

[Surgical treatment of native valve endocarditis].

Twenty eight patients with native valve endocarditis (NVE) were subjected to this study. Thirteen patients underwent an operation at the chronic phase, and 15 patients at the active phase. One of the 13 patients at the chronic phase died of cardiac rupture due to myocardial infarction which had occurred preoperatively, and one of 10 patients at active phase without annular infection died of rupture of mycotic cerebral aneurysm early postoperatively. Among 5 patients at the active phase with annular infection, prosthetic valve endocarditis occurred in one patient 1.5 months after supraannular aortic valve replacement, and the second operation with a translocation technique was needed. This patient was lost from low output syndrome. Another patient in this group, who underwent a translocation technique because of mycotic annular abscess, died of intestinal infarction late postoperatively. The other 24 patients went a good postoperative course. Five patients with annular infection at the active phase had a shorter duration from the infectious onset to operation (20 days to 2 months, average 38 days), and the causative microorganisms were streptococcus faecalis, staphylococcus epidermidis and gram-negative coccus. One patient, who died of mycotic cerebral aneurysmal rupture, had candida albicans as a causative microorganism. For patients with NVE, an early aggressive operation is essential before infection extends to the annulus or to other vital organs, especially when these microorganisms are identified.

Adult↗
PubMed1992

[Coronary artery bypass grafting in patients with poor left ventricular function using retrograde continuous cold blood cardioplegia].

Patients with poor left ventricular function or those requiring urgent surgery may have more extensive ischemic myocardial injury if myocardial preservation is incomplete. We have performed coronary artery bypass grafting (CABG) aimed at complete revascularization in such cases using RC-CBCP, which is considered more effective on myocardial preservation during aortic cross-clamping in particular to protect ischemic area distal to severe coronary artery stenosis or obstruction. In the present study, in 25 patients with poor left ventricular function (left ventricular ejection fraction; LVEF less than or equal to 0.3) including 10 patients who required urgent surgery, the operative results were evaluated. All the distal and proximal anastomoses of grafts (average 2.5 grafts) were completed during one aortic cross-clamping using RC-CBCP, therefore graft flow was obtained immediately after release of the aortic clamping. Though this method required 142 minutes of a mean aortic cross-clamping time, myocardial protection was considered to be preferable judging from postoperative isoenzymatic evaluation and improved ventricular function. Fifteen patients with elective CABG were all alive and restored to NYHA class I to II. Among 10 patients requiring urgent CABG, 4 patients with acute myocardial infarction died but others were restored to NYHA class I to II. We conclude that it is important to aim at complete coronary revascularization in patients with poor left ventricular function and RC-CBCP achieves more effective myocardial protection during CABG in the patients.

Adult↗
PubMed1992

[Coronary artery bypass grafting using retrograde continuous cold blood cardioplegia].

Coronary artery bypass grafting was performed in 166 patients with severe coronary artery disease using retrograde continuous cold blood cardioplegia (RC-CBCP) during the last 3 years and 8 months. In this study, myocardial protection was assessed from the aspect of enzymatic analyses and clinical results of these patients. Six hospital deaths were not related to the myocardial protection. Even in the groups of patients with medically refractory unstable angina, multiple occlusion of the coronary artery, low cardiac function and left main trunk lesion, RC-CBCP provided excellent protection of the myocardium and satisfactory results of operation as well as in each control group. Consequently we conclude that RC-CBCP affords safer and more effective myocardial protection in patients with severe coronary artery disease.

Adult↗
PubMed1992

[Retrograde continuous cold blood cardioplegia via coronary sinus].

Though the retrograde continuous cold blood cardioplegia (RC-CBCP) is a useful method of myocardial protection for more complicated cardiac surgery, the most important problem is whether the right ventricle is satisfactorily protected or not. In the present study 60 patients with valvular heart disease given RC-CBCP were compared with 30 patients given antegrade continuous cold blood cardioplegia. Judging from myocardial temperature measured in the right ventricular wall, the ventricular septum and the left ventricular wall at the end of initial cardioplegic infusion, myocardial distribution of cardioplegic solution in the RC-CBCP group was as favorable as in the antegrade group. Injury to mitochondria in the right ventricular myocardium observed in the biopsy specimen taken just prior to aortic unclamping was usually trifling in the RC-CBCP group, and was not different significantly from that in the antegrade group. Cold blood cardioplegia dose perfused per left ventricular mass weight (LVMW) had significant correlation with injury to mitochondria, and the dose of more than 5ml/100gLVMW/min seemed to be preferable. There was no hospital death in all patients. Peak CK-MB after unclamping was less in the RC-CBCP group than the antegrade group. In conclusion, RC-CBCP is a safe and effective means of myocardial protection for both right and left ventricles.

Blood↗