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T Auberger

Publications and source records attributed to T Auberger.

27 records · Page 2Linked to original sources
PubMed1996

In vivo neutron activation analysis of sodium and chlorine in tumor tissue after fast neutron therapy.

In 12 patients with recurrences and metastases of different primaries (head and neck cancer, breast cancer, malignant melanoma, and osteosarcoma) who were treated with reactor fission neutrons the photon emission of irradiated tissue was measured after each radiotherapy fraction. Spectral analyses of the decay rates resulted in data for the exchange of sodium (Na) and chlorine (Cl) between the irradiated tissue and the body. About 60% of Na and Cl exchanged rapidly with a turnover half-life of 13 +/- 2 min. New defined mass exchange rates for Na and Cl amount to an average of 0.8 mval/min/kg of soft tissue. At the beginning of radiotherapy the turnover of the electrolytes in tissues with large tumor volumes was about twice that in tissues with small tumor volumes. Depending on the dose, neutron therapy led in all cases to variation in the metabolism. A maximum of Cl exchange and a minimum of Na exchange occurred after 10 Gy of neutrons (group of six previously untreated patients) or after 85 Gy (photon equivalent dose) of combined photon-neutron therapy. A significant increase in non-exchangeable fraction of Na from about 40 to 80% was observed in three tumors after a neutron dose of 10 Gy administered in five fractions correlated with a rapid reduction of tissue within 4 weeks after end of therapy. These results demonstrate for the first time the local response of the electrolyte metabolism to radiotherapy.

Chlorides↗
PubMed1996

Neutrontherapy in soft tissue sarcomas: a review of European results.

The purpose of this publication is to review the data on European neutrontherapy facilities in the treatment of soft tissue sarcoma. Data on 1171 patients treated at 11 centers were analyzed. Neutrontherapy was of advantage especially for patients with primary radiotherapy of inoperable tumors, and those with macroscopic disease after surgery. Local control was about 50% in these groups. Results for postoperative neutrontherapy after R0 and R1 resection were similar to those for photon therapy. The incidence of late side effects was considerable. This was influenced by the fact that most patients were treated with first-generation machines.

Disease-Free Survival↗
PubMed1996

European results in neutron therapy of malignant salivary gland tumors.

In Europe to date, 501 patients with salivary gland tumors have been treated with neutrons alone or with combined modalities. The most common histological types are adenoid cystic carcinomas, mucoepidermoid carcinomas and malignant mixed tumors. The results of conventional radiotherapy are suboptimal in inoperable or incompletely resected salivary gland tumors and in recurrent disease. The pooled data of some international series for low linear energy transfer radiation show a local control of 28%. Especially in advanced tumors neutron therapy can improve local control and should be the treatment of choice. The clinical data from different therapy centers in Europe show local control of 67% in gross disease.

Carcinoma, Adenoid Cystic↗
PubMed1995

Uptake and distribution of the boron-containing ether lipid B-Et-11-OMe in tumor-bearing mice.

Ether lipids in general are accumulated in tumor tissue with a favorable tumor/healthy tissue ratio. The uptake of the boron-containing analog rac-1-(9-o-carboranyl)nonyl-2-methyl-glycero-3-phosphocholine (B-Et-11-OMe) was studied in C3H mice bearing the murine mammary carcinoma AT17 and in BALB/c mice bearing an osteosarcoma. Boron concentrations of tumor, blood, liver and kidney were followed up to 48 h by inductively coupled plasma emission spectrometry and inductively coupled plasma mass spectrometry. Boron concentration in AT17 mamma carcinoma rose up to 2 mg/kg and the tumor/blood ratio rose to 0.5. The bulk was taken up by the liver. Osteosarcoma did not take up B-Et-11-OMe. This result constitutes a significant contrast to the behavior of published (non-boron-containing) analogs. It is interpreted in terms of critical micellar concentration (CMC). Whereas earlier work with ether lipids was done well below CMC, this study was undertaken above. Further studies will concentrate on syntheses of high CMC analogs.

Adenocarcinoma↗
PubMed1995

An immunological outcome predictive score for head and neck carcinoma patients.

AIM: To address the increasing demand for individualization of tumor therapy, a panel of immunological parameters was evaluated as potential early prognosticators for the outcome of treatment. PATIENTS AND METHODS: Thirty-one patients with advanced squamous cell carcinomas of the head and neck were treated either with a 2-course radiation treatment (60 to 70 Gy total dose) in combination with and subsequent to the administration of mitomycin C and 5-fluorouracil (radiochemotherapy) or with radiotherapy (2 patients) only. In 8 patients radio(chemo)therapy was preceded by surgical removal of the tumor. Before, during and after therapy, patients were immunophenotyped (in absolute numbers) and the respiratory burst function of granulocytes (polymorphonuclear [PMN] cells) was evaluated flow cytometrically. RESULTS: Before treatment a reduction of T and B lymphocytes to 64% to 81% of the means of 101 controls (healthy volunteers and hematologic normal patients) was observed, absolute PMN counts were increased by 31%, whereas monocytes and natural killer cells were not influenced. The helper (TH)/suppressor-cytotoxic (Ts/c) T cell ratio was significantly elevated. The respiratory burst reaction of the majority (74%) of patients was normal. During therapy all lymphocyte populations declined further as did the PMN counts. Natural killer cells were not significantly influenced while absolute monocytes increased significantly beyond normal levels after initial depletions during each course of treatment. The helper/suppressor ratio was reduced to normal levels. Overall, treatment resulted in systemic effects at the level of leukocyte subpopulations and appeared to cause a shift of immunocompetence to a predominantly monocytic system. The deficiency in the humoral immune system could be correlated with the short survival time of most patients. Based on early effects of the treatment (after 10 Gy), an immunological outcome predictive score could be defined. A simple mathematical combination of the changes of B and Ts/c cells (after 10 Gy vs. 0 Gy) together with the respiratory burst reaction of PMN prior to treatment allowed retrospectively to classify correctly 90% (17/19) of patients as survivors (> 120 weeks) or early deaths (< 96 weeks; p < 0.01). CONCLUSION: Single individual immunological data were not able to function as prognosticators for longer survival after therapy, but a combination of 3 parameters measured early during radio(chemo)therapy seems to allow the identification of "sensitive" patients. In how far the tumor disease per se and/or the immunological "sensitivity" are causes of death in these patients requires further clarification.

Adult↗
PubMed1994

Metabolism and pathophysiology of sodium and chlorine in tissue after neutron irradiation.

The photon emission of tissue was measured after radiotherapy with various doses of fission neutrons. Spectral analyses of the decay rates resulted in data for the exchange of sodium and chlorine between the irradiated tissue and the whole body. In 12 cases we found that about three fifths of Na and Cl exchange rapidly between the extravascular and vascular liquids with a turnover half-life of 13 +/- 2 min. Slowly exchangeable or non-exchangeable fractions are deposited in the soft tissue. New defined mass exchange rates for Na and Cl amount to an average of 0.8 mval min-1 kg-1 of soft tissue. The turnover of the electrolytes in tissue with large tumours is about twice that in tissues with small metastasis. Depending on dose, radiotherapy led in all cases to distinct variations of the metabolism. A maximum of the exchange of Cl combined with a minimum of Na occurs at about 85 Gy of conventional or at 10 Gy of lead-filtered fission neutron radiation. These results show directly for the first time the local response of the electrolyte metabolism to therapy.

Chlorides↗
PubMed1985

Functional radiographs of the craniocervical region and the cervical spine. A new computer-aided technique.

Disabilities of the articulations of the head and cervical spine can often be detected only by exact measurement of functional radiographs. From two radiographs, one in flexion and one in extension, not only can the total mobility of the head be measured, but also the mobility of the individual articulations can be evaluated by taking exact measurements of the position of each vertebra. A method for semi-automatic measuring of such pairs of radiographs is presented. Edges and structures of the bones that are clearly visible in both radiographs are digitized on a graphics tablet. Then, by computer program, each vertebra of the first radiograph is shifted and rotated until it fits best to the respective vertebra of the second radiograph. Thus, for each articulation, the mobility angle and the location of the mobility axis relative to the adjacent vertebra, can be computed. First experiences with this method are presented.

Adult↗
PubMed1985

[Nuclear magnetic resonance tomography of the spine].

The present paper deals with the results of 48 MR examinations of known spinal abnormalities. The use of a method strictly related to the individual problem helps to reduce the duration of the examination. Sagittal cuts are particularly useful for demonstrating much of the spinal canal. The spin-echo method is used for all examinations. Demonstration of the cord was performed by using short repetition and echo times (TR, TE). For showing the outer margin of the spinal canal, longer TR and TE should be selected. Surface coils are important for demonstrating spinal disease, since the larger images can be performed without increasing the duration of the examination.

Humans↗