This study was undertaken to examine the relationship between electrographic ST-elevation and regional myocardial blood flow during graded coronary constriction. Electrograms from the epicardial surface, outer and inner layers of the myocardium were recorded. Regional blood flow to the outer and inner layers of the myocardium was measured by means of a heat-clearance method. With the application of a coronary constriction, myocardial blood flow to the inner layer began to decrease with a 75% coronary constriction, while flow to the outer layer was maintained at near normal up to least an 80% coronary constriction. Non-linear squares curve of between ST-elevation and the decrease in myocardial flow resulted in y = 18.80 exp-0.06x - 0.02 in the outer layer and y = 9.22 exp-0.02x - 1.54 in the inner layer. Also the non-linear squares curve of between epicardial ST-elevation and the decrease in myocardial flow resulted in y = 50.91 exp-0.11 x + 0.04 in the inner layer and y = 10.29 exp-0.07 x + 0.03 in the outer layer. The standard deviations of the coefficients of the latter two equations were higher than those of the former two equations. The higher values indicated larger variations of the parameter coefficients and data points. These results clearly demonstrated that a regional intramyocardial electrogram more closely reflects local ischemia than does an epicardial electrogram.

Animals↗

PubMedDate not supplied

Electromyographic responses in leg muscles after electrical stimulation in myelopathy patients with tonic seizures.

The electromyographic (EMG) responses in leg muscles after electrical stimulation of the peripheral nerves were examined in patients with myelopathy. The stimuli were delivered to the tibial nerve at the ankle joint. The EMG responses were recorded from the anterior tibial muscle at the latencies of 80-280 ms. In myelopathy patients with tonic seizures in the extremities, the EMG responses evoked both by single and repeated stimulation were frequently observed. Electrical stimulation also provoked the following tonic seizures in the legs. Stimulation of the back of the big toe or of the sural nerve, also produced the EMG responses in the anterior tibial muscle, and tonic seizure in the leg. There was no difference in the appearance of the EMG responses between patients with and without pain sensation during the seizure. A kind of flexor reflex might be related to tonic seizures in patients with myelopathy, at least in part.

Adult↗

PubMedDate not supplied

Auditory middle latency responses in patients with epilepsy.

Middle latency auditory responses (MLRs) were studied in 55 normal subjects and 49 epileptic patients. We evaluated the function of the auditory system and of the temporal lobe in epileptic patients using MLRs. (1) The patients with epilepsy had significantly prolonged Pa and Nb latencies and the significantly increased amplitude of Pa-Nb component. (2) The prolongation and the increase of MLR components in latency and amplitude were more obvious in patients with intractable epilepsy than patients without intractable epilepsy. (3) The difference between left and right sides was larger in epileptic patients than normal subjects. (4) Epileptic patients with polypharmacy had reduced amplitude of Pa-Nb component and prolonged latency of Pa component than patients with monotherapy. Antiepileptic drugs (AEDs) appeared to decrease the amplitude of Pa-Nb component. It was supposed that the enhancement of amplitude of Pa-Nb component represented the abnormality of central nerve system in epileptic patients, in part.

Adolescent↗