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Biomedical subjects

T B Dmitrieva

Publications and source records attributed to T B Dmitrieva.

33 records · Page 2Linked to original sources
PubMed1998

[The All-Russian Disaster Medicine Service].

Theoretical bases of creation, stages of development, normative-and-legal base, structure and problems of a All-Russia service of disaster medicine are stated. In article some questions about experience of rendering of the medical aid to the injured in the extreme situations (North Caucus region, Sakhalin, Budenovsk, Irkutsk), training of personnel, creation of reserves of medical property for extreme situations, organization of service management are submitted. The federal program "Perfection of All-Russia service of disaster medicine on 1997-2001 years" is considered in detail.

Disaster Planning↗
PubMed1986

[Clinico-biochemical approach to the problem of psychogenic disorders and background].

total of 270 patients with psychogenic disturbances were studied. Three levels of the interaction between the background and psychogenesis were specified. In accordance with these levels psychogenic disturbances were presented in the form of continuous changes from the typical to the atypical, from the predominance of the psychogenic to the predominance of the endogenic. Study of the metabolism of catecholamines in 45 patients with a nuclear form of psychopathy has shown that the biological factor plays an important role in the understanding of correlation between psychogenesis and the background.

Adolescent↗
PubMedDate not supplied

[Myelin basic protein. Structure, properties, function and role in diagnosing demyelinating diseases].

Physico-chemical properties and biological role of myelin basic protein (MBP)--one of the main myelin membrane proteins are reviewed. The data on MBP phosphorylation, methylation, fatty acid acylation and on interaction with lipid molecules in the human and animals bodies are presented. Much attention has been paid to the discussion of the diagnostic and clinical significance of the MBP, as the marker of demyelinating process in the central and peripheral nervous system.

Demyelinating Diseases↗
PubMedDate not supplied

[Criteria of efficiency of transplantation of embryonic nervous tissue preparations in rats with 6-OHDA-impaired dopaminergic nigrostriatal system].

Effectiveness of transplantation of cells from embryonal nervous tissue of the ventral mesencephalon (VM ENT) and striatum (STR ENT) by apomorphin-induced motor asymmetry (APO-test), consolidation of the transplant (the degree of glyal reaction and amount of dopaminergic neurons) and blood serum levels of GFAP was studied for 3 months in Wistar rats with 6-OHDA-impaired dopaminergic nigrostriatal system. Marked therapeutic effectiveness was registered in VM ENT transplantation in the denervated striatum and in combined transplantation of VM ENT into the lateral cerebral ventricle simultaneously with STR ENT transplantation in the striatum. Separate transplantation of VM ENT in the lateral ventricle and STR ENT in the striatum had no positive effect on recovery of the dopaminergic nigrostriatal system. A correlation was found between the degree of glial reaction of ENT transplants, severity of rotation asymmetry and serum levels of gliofibrillary protein (GFAP). GFAP in the serum for lifetime assessment of transplant consolidation and prognosis of neurotransplantation efficiency was assayed.

Animals↗
PubMedDate not supplied

[Production and characteristics of PEGylated immunoliposome transport vectors specific for neural tissue astrocytes].

PEGylated (stealth) immunoliposomes covalently linked to antibodies against human gliofibrillary acidic protein (GFAP) were prepared by coupling the thiolated monoclonal anti-GFAP antibodies, D4, with a maleimide derivative of the phosphatidyl ethanolamine of the liposomal membrane. Depending on the initial protein-to-lipid ratios, the immunoliposomes prepared (with a diameter of about 70 nm) were coupled with 60 to 240 molecules of the antibodies. In vitro experiments with cultures of the embryonic rat brain astrocytes demonstrated a specific binding of these immunoliposomes, which could be inhibited by the preincubation of the cells with free non-coupled D4 but not with non-specific antibodies. Administered intravenously into rats, the immunoliposomes exhibited a kinetic behaviour typical for the PEGylated liposomes: after 24 h, approximately 20% of the doses injected were still present in the blood; the elimination rate constants were 0.05-0.09 h(-1), the elimination half-lives were 8-15 h. With such a systemic longevity, as well as with such a specificity, these immunoliposomes, non-penetrating through intact blood-brain barrier (BBB), should be useful in delivering pharmacological agents to glial brain tumours (which continue to express GFAP) or to other pathological loci in the brain with a partially disintegrated BBB.

Animals↗
PubMedDate not supplied

[Myelin oligodendrogliocyte glycoprotein: the structure, functions, role in pathogenesis of demyelinating disorders].

Myelin oligodendrocyte glycoprotein (MOG) is a myelin-specific protein of the central nervous system (CNS). It is a member of the immunoglobulin superfamily. The contents of this protein in oligodendrogliocyte membrane is very low (approximately 0.1% total proteins). Functions of MOG are still unknown. It is considered that MOG is an autoantigen capable to produce a demyelinating multiple sclerosis-like disease in experimental animals. The structure, membrane topology, putative functions and role in demyelinating diseases are considered in this review.

Alternative Splicing↗
PubMedDate not supplied

[Relationship of free and conjugated forms of catecholamines in depressive disorders in psychopathic personalities].

The study was undertaken to examine the content of free and conjugated forms of norepinephrine, dopamine, epinephrine in the daily urine and blood plasma of psychopathic patients during varying severity depressive disorders. To isolate the conjugated forms, hot acid hydrolysis was applied, catecholamines were measured by the procedures based on high performance liquid chromatography with electrochemical detection. Patients with the most marked clinical signs of depressions were found to have the most profound urinary and blood shortage of free forms of dopamine and norepinephrine, as compared with the controls, which was associated with the most intensive conjugation of these catecholamines. Thus, it may be supposed that disturbances of the catecholamine conjugation systems are one of the neurochemical mechanisms underlying the development of affective disorders.

Adolescent↗