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T B Dunn

Publications and source records attributed to T B Dunn.

At least 19 recordsLinked to original sources
PubMed1984

Pure yolk sac carcinoma of the mouse uterus: report of 8 cases.

This report covered the pathologic features, behavior, metastases, and results of transplantation of pure yolk sac carcinomas that were primary in the uterine horn of 8 mice; 6 mice were strain C3H and 2 were strain HR, and they varied from 10 to 23 months of age. Three of the mice had never been treated. Of the 5 that had, the treatment was different for each mouse. Therefore, treatment could not be correlated with tumor development. At least 5 mice were nulliparous; in fact they had never been mated, so in these some mechanism involving parthenogenesis must have been operative to account for the tumor. The tumors were identified as being primary in the uterus and occupied and distended the cavity of one uterine horn where they were polypoid or plaquelike. The neoplastic yolk cells replaced the endometrial stroma forming a support for the original endometrial glands. In time the tumor cells destroyed many of the endometrial glands. That the glands present in the primary uterine horn tumors were the original glands of the endometrium and not neoplastic glands was attested by their absence from the secondary neoplastic deposits in 4 mice in which the tumor had spread to areas outside the cavity of the uterus and from the neoplastic tissue of the tumor transplants in the recipient mice.

Aging↗
PubMed1982

"Myeloma".

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Animals↗
PubMed1979

Classification of mouse mammary tumors in Dunn's miscellaneous group including recently reported types.

A classification of mouse mammary tumors in Dunn's miscellaneous group including recently reported types is presented. Adenocarcinoma type Y, first reported in (C3H X Y)F1 mice, is characterized by tubules that branch at acute angles and are lined by cuboidal epithelium. Adenocarcinoma type L is characterized by alcelike appearance and has projections of tumor cells with cytoplasmic vacuoles into lumina. Undifferentiated carcinomas in strains SWR/J and BABL/c contain sheetlike masses of epithelial cells with very little tendency to form glands but which may contain foci of cells with keratohyaline granules. Pale cell carcinomas, which occur in strain GR mice, are hormonally responsive and are characterized by the presence of pale cells and cystic spaces lined by basophilic cells. Foci of cells with acidophilic hyaline bodies and keratohyaline granules and with intercellular bridges distinguish this neoplasm from adenocarcinoma type B. A second hormonally responsive mammary tumor in strain GR mice is adenocarcinoma type P, which consists mainly of acini lined by a single layer of polyhedral cells. Carcinosarcomas of BALB/c mice have a myxoid stoma and, also containing glands, resemble mixed mammary tumors of the bitch. Criteria for differentiating trichoepitheliomas from mammary tumors are discussed.

Adenocarcinoma↗
PubMed1976

Registry of experimental cancers of the National Cancer Institute.

This report describes the organization and functions of the Registry of Experimental Cancers and gives the chronology of events that led to its establishment. Currently 21,500 accessions have been coded; the vast majority are spontaneous and induced cancers, chiefly of rodents, and also a wide variety of nonneoplastic diseases. Accessions are accepted from contributors working in laboratories in this country and abroad. The material is available for study by responsible scientists, and a limited number of study sets is available for loan on request.

Animals↗
PubMed1974

Leslie Foulds.

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England↗