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Biomedical subjects

T B Karasu

Publications and source records attributed to T B Karasu.

At least 91 records · Page 5Linked to original sources
PubMed1975

Thioridazine stimulates prolactin secretion in man.

Thioridazine, unlike most other effective antipsychotic drugs, appears to be only a weak dopamine antagonist in various regions of the brain. We decided to test, indirectly, thioridazine's effects on another brain dopaminergic system, the tuberoinfundibular tract, which regulates prolactin secretion by stimulating hypothalamic secretion of prolactin-inhibiting factor. Chlorpromazine and several other phenothiazines have been shown to stimulate prolactin secretion. Five healthy men ingested 50 mg of chlorpromazine concentrate on one occasion, and 50 mg of thioridazine concentrate on another. Both drugs noticeably stimulated prolactin secretion within two hours. It is concluded that thioridazine is a potent dopamine antagonist in the tuberoinfundibular system, and it is suggested that this system's regulation of prolactin secretion may provide a useful method for studying antipsychotic drug effects in man.

Administration, Oral↗
PubMed1975

Attitudes of psychiatric residents toward the necessity of internship.

The authors note that the elimination of the internship requirement for board certification has engendered much discussion and has called attention to the need for further study of training in psychiatry. To help clarify the issue, they investigated demographic and career choice factors, individual internship decisions, and perceptions and feelings about these decisions in 57 psychiatric residents. The results indicate that the career plans of students have a strong influence on their training choices--those who are oriented toward inpatient psychiatry and psychosomatic medicine view the internship as more relevant than those who plan to concentrate in other areas. The authors suggest further research on the relation between career choice and training preferences.

Adult↗
PubMedDate not supplied

Self-report measures as predictors of psychotherapy outcome.

A retrospective clinical study using existing patient records investigated the predictive value of a number of variables. Eighty-three new admissions to a large outpatient clinic completed a battery of eight self-report questionnaires that have been shown to be reliable and have a measure of discriminant validity. The battery consisted of items tapping anxiety, depression, obsessive-compulsive symptoms, phobias, borderline personality disorder, and histrionic, obsessive-compulsive, and paranoid personality styles. Outcome of therapy, which was predominantly dynamically-oriented, was assessed by residual difference scores computed from pre- and posttherapy Global Assessment Scale (GAS) ratings. Only patients attending five or more sessions (N = 37) were considered in the analyses. Patients high on the Anxiety Scale pretherapy showed relatively greater improvement in functioning than those with low initial scores. Patients scoring high on the Histrionic, Paranoid, and Obsessive-Compulsive Personality Scales showed the least relative improvement.

Adult↗
PubMedDate not supplied

Development of a scale for the measurement of symptom change in an outpatient clinic.

A brief 21-item symptom rating scale, the Psychiatric Outpatient Rating Scale (PORS), was developed for use in outpatient clinics. On the basis of its initial use with 86 patients, it was shown to have high internal and interjudge reliability and evidence of concurrent and construct validity. Scores on the PORS correlated significantly with the Global Assessment Scale and with the number of sessions of psychotherapy. For a subsample of 45 patients rated on the PORS at the beginning and termination of psychotherapy, seven symptoms revealed highly significant improvement. The PORS appears to be a potentially useful measure of change in outpatient clinics.

Adolescent↗
PubMedDate not supplied

Psychological mindedness as a predictor of psychotherapy outcome: a preliminary report.

This study investigated the properties of a new measure of psychological mindness (PM). A 45-item self-report questionnaire was administered to consecutive admissions to a large outpatient clinic that provides primarily psychodynamically oriented individual psychotherapy. The PM scores of a sample of 44 of these patients who attended a median of 15 sessions were correlated with several outcome measures obtained from retrospective chart reviews. These measures consisted of the number of sessions attended, discharge ratings, and change scores on a Global Assessment Scale (GAS) and on a symptom checklist. Coefficient alpha for the Psychological Mindedness (PM) Scale indicated high reliability. Total PM score correlated significantly with three of the outcome measures. Twenty of the 45-items were good predictors of one or more outcome measures.

Adaptation, Psychological↗
PubMedDate not supplied

Can personality traits predict psychotherapy outcome?

Ninety-six new admissions to a psychiatric outpatient clinic who attended a median of 14 therapy sessions completed a self-report Personality Profile Index prior to their first session. This index provides scores on eight dimensions of personality, a conflict measure, and a measure of social desirability. Scores were correlated with number of sessions and outcome as measured by a Symptom Checklist and by a Global Assessment Scale (GAS). Improvement was significantly related to number of sessions attended. Patients scoring high on being rejecting of others (rejection) were significantly less likely to show improvement after therapy. Rejection, aggression, passivity, and conflict were significantly related to the extent of symptoms and problems with which patients presented at the clinic.

Adaptation, Psychological↗
PubMedDate not supplied

Relationships between psychological mindedness and personality traits and ego functioning: validity studies.

Two studies further investigated the psychometric properties of the self-report Psychological Mindedness Scale (PMS), which has been shown to have good internal consistency and evidence of predictive and divergent validity. Its construct validity was investigated by assessing (1) whether total scores on the PMS of a group of medical students attending a personnel clinic in a psychiatric outpatient setting would be related in theoretically expected ways to their scores on a personality test; and (2) whether total scores on the PMS of a group of regular clinic patients would have the expected theoretical relationships to scores on a measure of ego functions. The findings of both studies provided support for the construct validity of the PMS.

Adaptation, Psychological↗
PubMedDate not supplied

Gender differences in recalled parental childrearing behaviors and adult self-esteem.

A retrospective questionnaire study investigated gender differences in the relations between the self-reported self-esteem of 155 psychiatric adult outpatients and their recalled experience of their parents' behavior toward them as children. There were no significant sex differences in degree of self-esteem. However, it had a higher correlation to parenting variables for the men than for the women, with maternal predictor variables accounting for 36% and paternal predictors accounting for 32% of the variance in the men's self-esteem. Neither combined maternal nor combined paternal variables were significant predictors for women. For men, parental acceptance/ autonomy was significantly and positively related and inconsistency negatively related to self-esteem. Paternal rejection but not maternal rejection was significantly associated with low self-esteem only for the women. The greater amount of variance explained by childrearing variables in the men's self-esteem scores was attributed to the earlier ego development and consequent increased individuation in women.

Adolescent↗
PubMedDate not supplied

The advanced practice of psychotherapy.

The advanced practice of psychotherapy involves deconstructing and transcending separate schools in the search for universal healing processes. Knowledge from major psychotherapeutic schools over the last 100 years, as well as ancient teachings over the last 5000 years, is distilled in the training and formation of the psychotherapist. Five major elements of training (theory, technique, the patient, the therapist, and the patient/therapist relationship), as well as one element in the therapist's formation (the person), are presented. To be a true healer, the clinician must cultivate his or her soul and spirit. Only then can the therapist guide the patient to reach his or her authentic self.

Humans↗