[Effect of the isobutyl ester of retinoic acid on the cellular composition of bronchoalveolar lavage and mitotic activity of alveolar macrophages-monocytes in rats].
Explore the source record for details and available documents.
Animals↗
Biomedical subjects
T B Mladkovskaia
Publications and source records attributed to T B Mladkovskaia.
[Circadian fluctuations in the mitotic activity of the alveolar macrophages-monocytes from mouse bronchoalveolar washings].
The mitotic activity of alveolar macrophages-monocytes (AM-M) from bronchoalveolar lavages of 18 male (Balb x Black 6) mice F1 has been studied twice a day: at 8.00 a. m. (9 mice) and 8.00 p. m. (9 mice). Significant diurnal variations of AM-M proliferation were found. The mitotic index was 3.07 +/- 0.3/1000 in the morning and 1.39 +/- 0.3/1000 in the evening (p < 0.002).
Animals↗
[The clinico-cytological parallels in exacerbated bronchial asthma].
The authors provide the data on estimation of the character and intensity of inflammation in the proximal and distal bronchi as well as in the respiratory compartment of the lungs, obtained as a result of an all-round examination including a cytological assay of the bronchoalveolar washing off of 31 bronchial asthma patients in the period of disease exacerbation. A correlation analysis is given between the interrelationship between the intensity of bronchial obstruction and the level of eosinophilia in peripheral blood, sputum and in bronchoalveolar washing off. It has been revealed that the relative content of eosinophils in bronchoalveolar washing off is in the best agreement with the intensity of bronchial obstruction.
Adolescent↗
[Difficulties in the diagnosis of chronic toxoplasmosis with lung involvement].
A case of chronic acquired toxoplasmosis combined with lung impairment is described. The diagnosis was made on the basis of the data obtained as a result of the use of the latest clinical and instrumental research methods and a specific serologic test. The diagnosis was verified morphologically on thin sections of the sputum. The authors provide data on the diagnostic search for approaches to the differentiation between parasitic diseases resulting in dissemination to the lungs with calcification of the foci and broncholithiasis, tuberculosis.
Animals↗
[The cellular composition of the bronchoalveolar washing in experimental anthracosis].
Bronchoalveolar lavage (BAL) was performed in albino random-bred adult male rats with pneumoconiosis. Fibrotic reaction in the lungs was induced by inhalation coal dust during 6 months. BAL comprised 90.9 +/- 1.2% of macrophages; 4.4 +/- 0.8% of neutrophils and 4.5 +/- 1.0% of lymphocytes. The total cell number in BAL was higher (over 59%) in animals with pneumoconiosis. The number of cells on alveolar surface of the lungs was also higher. Fibrotic reaction in the lungs is probably directly related with the increased number of vital macrophages in the lung.
Animals↗
[Mitotic activity of alveolar macrophages in nonspecific diffuse lung pathology].
Endopulmonary cytograms and mitotic activity of alveolar macrophages (AM) in the bronchoalveolar lavage (BAL) from 30 patients with diffuse lung pathology have been studied. AM mitosis was found in 24 cases. Mitotic index for all the patients was 0.65% and ranged from 0.25 to 2.75%. Electron microscopy revealed the capacity of differentiated forms of AM for mitotic division. Free AM may be regarded as slowly proliferating cell population, capable of self-reproduction in lung pathology.
Adult↗
[A case of alveolar microlithiasis].
A case of alveolar microlithiasis diagnosed on the basis of a clinical and x-ray picture was described. The diagnostic value of an endopulmonary cytogram in this patient was discussed. The authors investigated bronchoalveolar washing off obtained from bronchoalveolar lavage for morphological diagnosis of this pathology.
Adult↗
[Characteristics of the intrapulmonary cytogram in compensatory lung hypertrophy].
Bronchoalveolar lavage (BAL) was performed on days 1, 3, 5 after left-side extirpation of the lung in albino random-bred adult male rats. BAL cell composition was studied. Compensatory lung growth was shown to be accompanied by restoration of BAL total cell number. BAL comprised 81.7% of macrophages, 15.6% of neutrophils and 2.5% of lymphocytes. The number of neutrophils was high (over 20%) in animals with postoperative pneumonia.
Animals↗
[Diagnosis of the crying cat syndrome].
Explore the source record for details and available documents.
Child, Preschool↗
[Pulmonary alveolar microlithiasis].
The paper reports a case of pulmonary alveolar microlithiasis in a 37-year-old female. The diagnosis was established clinically and roentgenologically. The cells of bronchoalveolar lavage were studied morphologically including transmission and scanning electron microscopy. Increased functional activity of alveolar macrophages (AM), a ten-fold increase of their mitotic index, numerous polynuclear AM and foreign-body cells have been revealed.
Adult↗
[The characteristics of the prenatal morphogenesis of human lungs in the area of the action of the radiation factors after the accident at the Chernobyl Atomic Electric Power Station].
The effects of irradiation at low doses on prenatal development were studied using the abortion materials from the controlled zones of Bryansk Province, Russia. A possibility of transplacental transition of some radionuclides (90Sr and 137Cs) was shown, as well as appearance of their traces in tissues of some fetuses starting from the second trimester of pregnancy. The presence of radionuclides in the muscle and bones was combined in some cases with teratogenic effects, including lung hypoplasia. Reliable delay of the bronchi branching according to the morphometry of lung histological sections was found in the offspring of irradiated mothers during the first trimester of pregnancy, thus suggesting disturbed prenatal morphogenesis of the lungs. Lung hypoplasia was sometimes noted during the second and third trimesters of pregnancy. The lymphoid cells of the lungs in fetuses were activated and a trend was found to enhanced extravascular local erythroid hemopoiesis. This is considered by the authors as compensatory-adaptive cellular reactions in the respiratory organs to tissue hypoxia and antigenic stimuli from the irradiated maternal organism.
Abortion, Therapeutic↗
[The importance of the cytological study of the tracheobronchial aspirate in newborn infants with the respiratory distress syndrome who are on artificial pulmonary ventilation].
Cytological and pH-metrical investigations of the tracheobronchial aspirate were performed in 43 children with a respiratory distress syndrome (RDS) on artificial pulmonary ventilation. The content over 40% in the cytogram of polymorphonuclear leukocytes (PNL) indicated infectious genesis and below 10%--noninfectious genesis of RDS. The content of PNL in the range of 11-39% requires additional clinical data which would help to establish RDS cause.
Bronchoalveolar Lavage↗
[Morphological characteristics of lungs in embryos and fetuses in women living in regions contaminated with radionuclides after accident at the Chernobyl power plant].
The possibility of transplacental passage of Cr-90 and Cs-137 as well as their traces appearance in descendants muscles and bones beginning from the 2nd pregnancy trimester (and this was sometimes associated with teratogenic effects) was demonstrated on the abortion material (human embryos and fetuses) from the controlled zones of the Bryansk region. Statistically significant inhibition of the bronchial branching (according to the morphometry of the lung histological section) this indicating the disturbance of the lung prenatal morphogenesis during the "pseudoglandular" developmental stage was observed in the 1st trimester of the pregnancy in the descendants of the irradiated mothers. Lung hypoplasia was observed in some cases in the 2nd and 3rd trimesters of the pregnancy. Activation of lymphoid cells in the fetal lungs and the tendency to the enhancement in them of the ectopic erythroid hemopoiesis was revealed. These processes are considered as a reflection of the compensatory adaptive cellular reaction in the descendants respiratory organs in response to the tissue hypoxia and antigenic stimuli from the organism of the pregnant woman irradiated after the Chernobyl accident.
Adult↗