Rapid determination of diazoxide in plasma and urine of man by means of high-performance liquid chromatography.
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Chromatography, High Pressure Liquid↗
Biomedical subjects
T B Vree
Publications and source records attributed to T B Vree.
Simultaneous determination of diazepam and its metabolies N-desmethyldiazepam, oxydiazepam and oxazepam in plasma and urine of man and dog by means of high-performance liquid chromatography.
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Animals↗
Determination of nitrofurantoin (Furadantine) and hydroxymethylnitrofurantoin (Urfadyn) in plasma and urine of man by means of high-performance liquid chromatography.
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Chromatography, High Pressure Liquid↗
Determination of plasma and renal clearance of cefuroxime and its pharmacokinetics in renal insufficiency.
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Adolescent↗
Dissolution, bioavailability and pharmacokinetics of three nitrofuratoin preparations in man.
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Adult↗
Determination of trimethoprim and sulfamethoxazole (co-trimoxazole) in body fluids of man by means of high-performance liquid chromatography.
A high-performance liquid chromatographic method for the determination of trimethoprim, sulfamethoxazole and its metabolite and a series of structurally related sulfonamides is described. The half-life time of elimination of sulfamethoxazole and its metabolite N4-acetylsulfamethoxazole is 9 h for both compounds. The renal excretion rate of sulfamethoxazole depends strongly on the urinary pH. The renal excretion rate of the metabolite N4-acetylsulfamethoxazole is not dependent on the urinary pH.
Chromatography, High Pressure Liquid↗
Rapid determination of amoxycillin (clamoxyl) and ampicillin (penbritin) in body fluids of many by means of high-performance liquid chromatography.
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Amoxicillin↗
Non-enzymic conversion of pyruvate in aqueous solution to 2,4-dihydroxy-2-methylglutaric acid.
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Animals↗
Enhanced plasma concentrations of gamma-hydroxybutyric acid in alcoholics.
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Alcoholism↗
Determination of flunitrazepam in body fluids by means of high-performance liquid chromatography.
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Animals↗
Mass spectrometry of cannabinoids.
The mechanism of fragmentation of cannabinoids to fragments m/e 314, 299, 271, 258, 246, 243, and 231 is given. Cannabidiol cannabinoidiol, cannabinol, delta6- and delta1-tetrahydrocannabinol, cannabichromene, cannabicyclol, derivatives with pentyl, propyl, and methyl side chains, their methyl ethers, and cis-trans and ortho-para isomers were analyzed by GLC-mass spectrometry using different energies for fragmentation during GLC elution. The following mechanism was distinguished: loss of a methyl radical, ring closure and rotation, McLafferty rearrangement, retro Diels-Alder, internal protonation, isomerization and internal bond formation, and one-step fragmentation to m/e 231.
Cannabinoids↗
Rapid determination of 4-hydroxybutyric acid (Gamma OH) and 2-propyl pentanoate (Depakine) in human plasma be means of gas-liquid chromatography.
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Autoanalysis↗
Radip induction of ether anaesthesia and controlled maintenacne by a combination of intravenous and inhalation administration without the risk of explosion.
The induction and maintenance of anaesthesia with ether using a combined intravenous infusion and a constant low inspired concentration are discribed. Predictions from a mathematical model were checked against animal experiments. Anaesthesia occurred within 5 min. The mehtod obviates the need for explosive mixtures.
Anesthesia, Endotracheal↗
Pharmacokinetics of sulphamethoxazole in man: effects of urinary pH and urine flow on metabolism and renal excretion of sulphamethoxazole and its metabolite N4-acetylsulphamethoxazole.
A high performance liquid chromatography method for the determination of sulphamethoxazole and its metabolite N4-acetylsulphamethoxazole is described. The renal excretion rate and cumulative renal excretion of sulphamethoxazole is markedly influenced by urinary pH. With constant urinary pH, the renal excretion rate and the renal clearance of sulphamethoxazole is dependent on the urine flow. The renal clearance of the metabolite N4-acetylsulphamethoxazole is not influenced by urinary pH or urine flow. No clear acetylator phenotype could be detected in the group of volunteers studied. The extent of acetylation depends on the amount of sulphamethoxazole available for acetylation, thus indirectly on the urine pH and flow.
Absorption↗
Pharmacokinetics of N1-acetyl- and N4-acetylsulphamethoxazole in man.
The pharmacokinetics of N1-acetylsulphamethoxazole and N4-acetylsulphamethoxazole in man are described. N1-Acetylsulphamethoxazole is deacetylated to sulphamethoxazole and acetylated to N4-acetylsulphamethoxazole. N4-Acetylsulphamethoxazole is excreted almost unchanged in the urine. The renal excretion rate is independent of the urine flow and urinary pH. N4-Acetylsulphonamides are less lipid soluble and more acidic than their corresponding parent sulphonamides.
Acetylation↗