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Biomedical subjects

T Barbui

Publications and source records attributed to T Barbui.

At least 343 records · Page 19Linked to original sources
PubMedDate not supplied

A retrospective study on oral anticoagulant prophylaxis in 103 Italian patients with hereditary thrombophilia and thrombosis. ad hoc Study Group.

The clinical records of 103 Italian patients with inherited thrombophilia and thrombosis were reviewed to estimate the incidence of thrombotic recurrences and major bleeding complications according to the different duration of oral anticoagulant prophylaxis (OAP). The incidence of the first thrombotic recurrence was 2.9, 7.4 and 10.8 x 100 patients/year, respectively, in subjects receiving lifelong OAP, stopping OAP after a mean of 9 months (range 1-30 months) or not receiving OAP. The probability to remain free from thrombotic recurrences in patients undergoing lifelong OAP, as estimated by the Kaplan-Meier method, was significantly higher in comparison with untreated patients (p less than 0.001), but did not reach the statistical significance in comparison with patients who stopped prophylaxis. The incidence of further thrombotic recurrences was 1.2, 21.1 and 22.3 x 100 patients/year, respectively, in the three groups defined above. The difference between patients who prolonged indefinitely OAP vs those who stopped or did not receive OAP was statistically significant (p = 0.003). Two intracranial bleedings, one of which fatal, were observed in patients undergoing lifelong OAP, whereas no major bleeding complications occurred in the other two groups. Our study supports the recommendations to continue indefinitely OAP in patients with inherited thrombophilia and recurrent thrombosis, but suggests caution in starting lifelong prophylaxis soon after the first thrombotic event in all patients.

Administration, Oral↗
PubMedDate not supplied

Failure to measure plasma activated factor XIII during disseminated intravascular coagulation.

The search for activated products of coagulation factors in blood is of considerable clinical interest because its detection would indicate activation of the clotting system. Factor XIII circulates as inactive zymogen and becomes enzymatically active after thrombin or factor Xa activation. Employing an amine-incorporating system, activated factor XIII was measured in normal and pathological plasma from leukemic patients with overt laboratory signs of disseminated intravascular coagulation (DIC). Only traces of the activated factor were detected in both normal and DIC plasma. The method, sensitive and specific, as shown by the results of measurements on the plasma of 8 patients with congenital deficiency and on normal serum, did not prove to be useful for detecting pathological in vivo thrombin generation.

Acute Disease↗
PubMedDate not supplied

Diagnostic and prognostic significance of platelet-bound IgG measurement in immune thrombocytopenic purpura.

The test proposed by Dixon et al. is an important contribution to the technique for detection of platelet-associated antibody. This test measures platelet-associated IgG by a complement-mediated red blood cell lysis-inhibition technique. We have used the direct Dixon test to study 44 cases of immune thrombocytopenic purpura and 90 controls, including subjects with nonimmune thrombocytopenic purpura and healthy subjects. Increased PAIgG was noted in 86.3% of ITP patients. However, the pretreatment values of PAIgG were not helpful for predicting the therapeutic response to either prednisone or splenectomy. Six patients in long-term clinical remission had normal platelet counts and distinctly abnormal PAIgG values. This condition was associated with qualitative platelet functional defects. This latter finding seems to be of diagnostic interest and deserves further investigations.

Adolescent↗
PubMedDate not supplied

Association between lupus anticoagulant and epilepsy.

Lupus anticoagulant associated with thrombocytopenia, thrombosis or recurrent abortions was diagnosed in 2 epileptic patients chronically treated with anticonvulsant drugs. The immunoglobulin fractions containing the anticoagulant activity were isolated and characterized. A search for lupus inhibitor was carried out in 96 consecutively examined patients, but no further cases were found. Although rarely, lupus anticoagulant and epilepsy may be associated. Whether lupus anticoagulant is causally related with epileptic seizures or secondary to the use of antiepileptic drugs remains to be established.

Abortion, Habitual↗
PubMedDate not supplied

Idiopathic thrombocytopenic purpura and pregnancy. Maternal platelet count and antiplatelet antibodies do not predict the risk of neonatal thrombocytopenia.

The aim of this study was to try to better characterize, on the basis of maternal platelet count and antiplatelet antibodies, women with ITP or a history thereof at risk of being delivered of a child affected by neonatal thrombocytopenia. Results show that either clinical classification or maternal platelet count were not effective in predicting the occurrence of neonatal thrombocytopenia. Effects of prednisone on platelet-bound and unbound antibodies were studied prospectively in 12 non-pregnant women with ITP; no increase of these parameters was observed after treatment. Thus, the risk of corticosteroid therapy in the management of pregnant ITP patients remains hypothetical and unproven.

Adult↗
PubMedDate not supplied

Prevalence of antithrombin III deficiency in blood donors selected for personal or familial history of venous thrombosis.

Antithrombin III (ATIII) was measured using a functional assay in 692 (6.7%) out of 10,332 blood donors selected for their personal or familial history of venous thrombosis. Three subjects with low levels of the protein were observed. Thus, the prevalence of ATIII deficiency was of 0.43%, corresponding to a prevalence of 0.03% in the general population. On the basis of family studies and of clinical and laboratory investigations, inherited ATIII deficiency was excluded and reduced levels of the inhibitor were attributed to an impaired liver function, despite normal blood coagulation tests. Therefore, in this study inherited ATIII deficiency cases were not found; however, acquired ATIII deficiency associated with normal clotting tests might represent a rare but definite risk factor for thrombosis.

Antithrombin III Deficiency↗
PubMedDate not supplied

The chronic proliferative disease of large granular lymphocytes.

This review deals with the chronic lymphoproliferative disease of large granular lymphocytes endowed with T and natural killer cell characteristics. The disease is sufficiently characterized to allow its distinction from other lymphoproliferative disorders of the T cell type. The heterogeneous clinical course and laboratory findings illustrate the complexity of the interaction between proliferating large granular lymphocytes and other haematopoietic cells.

Antigens, Differentiation, T-Lymphocyte↗
PubMedDate not supplied

Integrated use of morphology, cytochemistry, and immune marker analysis to identify acute leukaemia subtypes.

One hundred and thirty-three acute leukaemia cases were evaluated by using a simplified sequence of morphological, cytochemical, and immunological investigations in order to obtain a correct leukaemia characterization that could have clinical relevance, rather than look for FAB-immunophenotype correlates. This approach offered an effective support to immediate therapeutic decisions and further investigations.

Acute Disease↗