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T Baron

Publications and source records attributed to T Baron.

40 records · Page 3Linked to original sources
PubMedDate not supplied

Transplantation of canine malignant lymphomas in the nude and SCID mouse.

Canine lymphoid tumours, which share a number of features with human non-Hodgkin's lymphomas, were grafted in nude or SCID mice. Two (DL.24,DL.31) out of eight lymphomas and two (DL.31,DL.35) out of three lymphomas produced a sub-cutaneous (s.c.) tumour in nude and SCID mice respectively. In all animals, the s.c. tumours that developed at the inoculation site were regularly associated with metastasis to the regional lymph nodes, and also to the spleen, liver and bone marrow in SCID mice. The four transplanted tumours, with a pseudo-diploid canine karyotype, were diffuse large cell lymphomas as the initial dog tumours, and could be immunophenotypically characterized by surface immunoglobulins, MHC-class 2 and Thy-1 antigens. Serially transplanted lymphomas in nude and SCID mice may hence be used for further studies of these tumours.

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Serial transplantation and characterization of a canine diffuse large cell lymphoma grafted in nude mice.

A continuous canine lymphoma cell line (DL. 24N) was established by serial transplantation from a diffuse large cell lymphoma into athymic nude mice, yielding subcutaneous tumours at the injection site associated with lymph node metastasis. The transplanted tumour cells, of canine origin as assessed by the karyotype, appear comparable to the large non-cleaved and immunoblastic human cells, as did the initial tumour cells. Immunological studies show reactivity with antibodies to dog immunoglobulins, DT-2 and Thy-1, to MHC-class II antigens, and to both CD10 (CALLA) and CD21 (CR2) human antigens. Such a cell line, showing similarities with some of the human diffuse large cell lymphomas, will thus provide a new tool for further comparative studies of malignant lymphomas.

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PubMedDate not supplied

Intra-cranial transplantation of canine malignant lymphomas in the nude mouse.

Intra-cranial grafts of two canine lymphomas, previously maintained by serial sub-cutaneous (s.c.) transplantation, were performed in the nude mouse, in an attempt to characterize lymphoma cell lines in that species which could provide a model of human diffuse large cell B non-Hodgkin's lymphomas. In one of them (DL.24N), the metastatic lesions in the lymph nodes and spleen were unexpectedly predominant, whereas the i.c. growth of the tumour cells, detected histologically, did not lead to any clinical manifestation. In the other one (DL.31N), the i.c. tumour growth led to early clinical symptoms, whereas no metastasis outside the central nervous system could be detected. These observations could provide an interesting tool for studies of the metastatic behaviour of lymphomas.

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