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Biomedical subjects

T Beer

Publications and source records attributed to T Beer.

9 recordsLinked to original sources
PubMed1997

Acyclovir-induced colitis.

Three patients developed acute colitis, either de novo, or as an exacerbation of pre-existing colitis, following the use of oral acyclovir, prescribed for Herpes zoster or Herpes simplex infection. Rechallenge with oral acyclovir was performed in one patient, and resulted in a recurrence of colitic symptoms. It is speculated that acyclovir can have a direct irritant effect on large bowel mucosa.

Acyclovir↗
PubMed1996

A simian varicella virus (SVV) homolog to varicella-zoster virus gene 21 is expressed in monkey ganglia latently infected with SVV.

We have sequenced a simian varicella virus (SVV) open reading frame (ORF), 3,123 bp in length, whose product has 51% amino acid homology with the sequence encoded by the ORF of varicella-zoster virus gene 21. Several regions are highly conserved between the two ORFs, with homologies of approximately 80%. The SVV gene is transcribed in tissue culture cells productively infected with SVV and in monkey ganglia latently infected with SVV.

Amino Acid Sequence↗
PubMed1995

Configuration and terminal sequences of the simian varicella virus genome.

The simian varicella virus (SVV) genome is a linear DNA molecule consisting of a unique short (Us) and a unique long (UL) region. The Us is bounded by internal (IR) and terminal inverted repeats and inverts such that virion DNA contains equimolar amounts of two genome isomers. We have sequenced the right and leftward termini and the UL-IR junction region of the SVV genome. A sequence motif common to other herpesviruses, consisting of A and T residues surrounded by G+C-rich regions, was found near the rightward terminus of the SVV genome. Sequence analysis showed no repeats surrounding the UL region of the genome. Nucleic acid hybridization and polymerase chain reaction (PCR) amplification using primers from the right and leftward ends of the SVV genome indicated that the UL region inverts. PCR amplification also showed that, compared with virion DNA, SVV genomes with connected termini are increased in infected cell DNA, suggesting the presence of circular or concatemeric genomic molecules.

Base Sequence↗
PubMed1995

Comparison of values of antibody to Bordetella pertussis antigens in young German and American men.

Pertussis is well controlled in the United States by routine childhood immunization. In contrast, this disease is endemic and epidemic in Germany because routine immunization has not been implemented. To gain information relating to the epidemiology of Bordetella pertussis infections, we examined the prevalence and magnitude of B. pertussis agglutinins and of IgG and IgA antibodies (detected by enzyme-linked immunosorbent assay) to four B. pertussis antigens--lymphocytosis-promoting factor, filamentous hemagglutinin, pertactin, and fimbriae-2--in the sera of 119 American university students and 119 German military recruits of similar age. Geometric mean titers of agglutinins and geometric mean values for IgG antibodies to the four antigens were two- to threefold higher in sera from the American students than in sera from German recruits. In contrast, the geometric mean IgA values and the percentage of subjects with detectable IgA antibodies to the four antigens were similar in the two populations. Since IgA antibody results mainly from infection and not from immunization, our data suggest that B. pertussis infections are common among both American and German young adults despite the marked difference in rates of clinical pertussis in the two countries.

Adult↗
PubMed1995

Configuration of latent varicella-zoster virus DNA.

The configuration of latent varicella-zoster virus (VZV) DNA was analyzed by PCR. Template DNA for both internal and terminal VZV primers was present in a 1:1 ratio in ganglionic DNA, compared with a 15:1 ratio in DNA extracted from VZV virions, indicating that the VZV genomic termini are adjacent in latently infected human ganglia.

Adult↗
PubMed1990

Effects of gastrin and secretin on intestinal calcium absorption in the rat.

We studied the effect of physiological and supraphysiological plasma levels of gastrin and secretin on duodenal calcium absorption (CaA) in the growing rat. During infusion of either synthetic human gastrin 17 I (0.05, 0.1 or 0.25 micrograms/kg BW h, i.v.), synthetic porcine secretion (0.06, 0.125 or 0.25 CU/kg BW h, i.v.) in vehicle (0.15% BSA in saline), or vehicle alone, duodenal lumen-to-plasma flux, plasma-to-lumen flux and the net absorption of calcium were determined by in situ perfusion. While plasma gastrin- or secretin-like immunoreactivity rose to postprandial-like levels with increasing infusion doses, the bidirectional Ca fluxes, serum Ca, parathyroid hormone and concomitant urinary Ca excretion were not changed by any hormone infusion as compared with rats receiving intravenous vehicle only. We conclude that a physiological short-term regulating role of these hormones in duodenal CaA is unlikely in the growing rat.

Animals↗