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Biomedical subjects

T Ben Mosbah

Publications and source records attributed to T Ben Mosbah.

14 recordsLinked to original sources
PubMed1991

Dermal dendrocytes and photochemotherapy.

We studied the fate of dermal dendrocytes in patients treated with psoralens and ultraviolet light by combining immunohistochemistry and computerized image analysis. Factor-XIIIa-positive dermal dendrocytes were found to be altered in these patients. When compared with controls, dermal dendrocytes were often increased in number and had an uneven size and tissue distribution. Their cytoplasm was occasionally fragmented. These changes were more pronounced when early photosclerosis was present. The alterations described probably reflect vascular changes, and may be responsible for immunomodulating actions and disorder of the connective tissue structure induced by ultraviolet light.

Adult↗
PubMed1991

Comparative morphometric study of eruptive PUVA-induced and chronic sun-induced lentigines of the skin.

Computerized image analysis was used to compare lentigines (brown freckle-like cutaneous spots) induced by treatment with psoralens and ultraviolet light A (PUVA-induced lentigines) with those induced by solar exposure (actinic lentigines). For these conditions, which appear to be distinctive clinically and histologically, the number, size and shape of the macules were analyzed, revealing significant differences in the two latter parameters. This indicates that UV irradiations of different wave lengths act differently on melanocytes and/or on the interrelation between melanocytes and keratinocytes. The overall effect is much more self-limited in PUVA lentigines than in actinic lentigines, suggesting that the pathophysiology of these lesions is probably different.

Humans↗
PubMed1990

Early dermato-pathological signs during bath-PUVA therapy.

The combination of trioxsalen bath and long-wave UV-A is used in dermatology to treat selected patients with psoriasis. Such treatment induces side effects whose clinical aspects have already been described. We report the histological aspects of these lesions. The most striking features occur in the epidermis, where we found vacuolar alterations, disorganization of the stratum malpighi, necrotic cells, and Bowenoid changes. Langerhans cells are reduced in number, and melanocytes may become large and atypical. In addition, factor XIIIa-positive dendrocytes of the superficial dermis increase in size, and some of them migrate into the epidermis, which is a rare location for these cells.

Adult↗
PubMed1989

Adverse effects of topical corticosteroids.

Topical corticosteroids may induce local and systemic adverse reactions. Some of the corticosteroids are at low risk to induce several manifestations, but gross overdosage or misuse of the most potent steroids are responsible for a number of adverse reactions. An overview of the effects of topical corticosteroids upon the different structures of human skin is presented here.

Administration, Topical↗