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Biomedical subjects

T Bergner

Publications and source records attributed to T Bergner.

At least 19 recordsLinked to original sources
PubMed1993

Evaluation of phototoxic properties of some food additives: sulfites exhibit prominent phototoxicity.

Additives are used widely to enhance the quality of food products. To identify possible phototoxic properties, 13 food additives (benzoic acid, sodium benzoate, 4-hydroxybenzoic acid, 4-hydroxybenzoic acid methyl ester, 4-hydroxybenzoic ethyl ester, 4-hydroxybenzoic acid propyl ester, p-hydroxybenzoic acid n-butyl ester, benzyl alcohol, sorbic acid, potassium sorbate, propionic acid, sodium disulfite and sodium sulfite) were evaluated in vitro by means of a photohemolysis test using suspensions of human erythrocytes. Irradiation was performed with various light sources differing with regard to their spectral irradiance. Sodium sulfite and sodium disulfite induced photohemolysis up to almost 100%, the effect depending on the concentration of the compounds and UV dose administered. Radiation rich in UVB was most effective; a sunlight-simulating lamp induced photohemolysis to a lesser degree. All other substances tested did not cause significant photohemolysis. As sulfites are frequently encountered, they may contribute to UVB sensitivity. The clinical significance of these findings has to be established by further work.

Dermatitis, Phototoxic↗
PubMed1993

[Polymorphous light dermatosis. Clinical data and test results].

In a retrospective study, the clinical data of 424 patients, 340 (= 80.2%) female and 84 (= 19.8%) male, with polymorphous light eruption (PLE) were evaluated; 89.1% of the patients had skin type II or III (according to Fitzpatrick). 368 Photoprovocation testing was performed on 332 of these cases. The duration of PLE was (mean +/- SD) 7 +/- 6.9 years, and the age at onset of the disease was 28 +/- 14 years. In 40.1% of the patients PLE developed without seasonal accentuation. Predilection sites for skin lesions were the extensor aspects of the upper arm or forearm (69.0%/66.7%) and the chest (59.5%); the face and the back of the hand were less frequently (41.0%/40.8%) affected. In most cases (53.6%/18.3%), the skin lesions were papular or erythemato-urticarial in type. The minimal erythema dose for UV-B was found to be normal in all 311 cases in which it was assessed. Photoprovocation testing yielded skin lesions of PLE in 38.4% of the female, and in 58.5% of the male patients. The frequency of positive reactions to photoprovocation testing was directly related to the duration of the disease, the persistence of naturally occurring lesions, and the time interval from accidental exposure to the development of lesions.

Adolescent↗
PubMed1992

Photosensitization caused by ibuprofen.

Several nonsteroid antiinflammatory drugs (e.g., benoxaprofen, carprofen, and piroxicam) are known to induce photosensitivity reactions, but this has not yet been documented for ibuprofen. We observed a photosensitivity reaction in a patient treated with an oral ibuprofen preparation. This patient had a lowered minimal erythema dose for UVA but not for UVB after oral administration of ibuprofen. Results of a photopatch test with the drug were negative. In vitro UVA irradiation of human erythrocytes in the presence of ibuprofen caused ultraviolet dose-dependent phototoxic hemolysis.

Adult↗
PubMed1992

Malignant melanoma in association with phototherapy.

A 54-year-old Caucasian male suffering from psoriasis had been treated in 1978 and 1980 with PUVA (cumulative UVA dose 492.5 J/cm2) and from 1980 to 1989 with UVB (cumulative UVB dose 264.5 J/cm2). Other occasional treatment had comprised the topical administration of glucocorticosteroids, dithranol or tar. In 1989, on the upper part of the patient's back a newly developed pigmented skin lesion was excised under the clinical diagnosis of a pigmented, dysplastic nevus. Histological examination revealed a superficial spreading malignant melanoma (0.4 mm thick, Clark level II). In this case, exposure to high cumulative doses of therapeutic UV irradiation might have played an etiological role for the development of malignant melanoma.

Humans↗
PubMed1992

Red lunulae in severe alopecia areata.

The development of red nail lunulae has been extremely rarely described in alopecia areata. We observed 2 patients, a 30-year-old woman and a 61-year-old man, both suffering from severe alopecia areata, and having red lunulae. The colour changes, which developed a few weeks after the acute onset of hair loss, disappeared slowly, leaving horizontal fissures (Beau's lines).

Adult↗
PubMed1992

Demonstration of olaquindox phototoxicity in vitro.

Olaquindox is an oral anti-bacterial agent used as an additive to animal food. It is known to cause photosensitization in pig breeders, probably due to a photoallergic mechanism. Also, olaquindox was found to be phototoxic in animal experiments. We have evaluated the phototoxic properties of olaquindox in vitro with a photohemolysis test using different light sources. Irradiation with a source rich in ultraviolet A (UVA) and, to a lesser degree, with a lamp emitting mainly visible light induced photohemolysis, which depended on the concentration of olaquindox and the radiation dose. Exposure to radiation rich in UVB caused no olaquindox-dependent hemolysis. The absorption spectrum of olaquindox changed prominently after irradiation, indicating photodegradation of the compound.

Dermatitis, Phototoxic↗
PubMed1992

[Impaired work capacity in dermatologic expert assessment].

Loss of earning capacity caused by skin diseases frequently has to be assessed by accredited dermatological experts. Assessments must take account of the appropriate legal situation in each case. Each case needs to be carefully and individually evaluated; tabulated estimations can only be used as a basis.

Dermatitis, Contact↗
PubMed1991

Annular erythema associated with Sjögren's syndrome: a variant of systemic lupus erythematosus.

We present a Burmese patient with widespread annular erythema associated with Sjögren's syndrome. Unlike previously described cases, the disease occurred in the setting of systemic lupus erythematosus. Photoprovocation testing revealed light sensitivity in the UVA range with elicitation of subacute cutaneous lupus erythematosus-like lesions. The presence of an erythema annulare centrifugum-like eruption should initiate the search for Sjögren's syndrome and systemic lupus erythematosus.

Adult↗
PubMed1991

[Solitary and multiple granular cell tumors. Case reports and review of the literature].

Two patients with multiple granular cell tumours (GZTs) of the skin and one patient with GZT of the tongue are reported. The tumours had been becoming larger for several years without subjective symptoms. Only the GZT of the tongue was diagnosed correctly before surgery; the cutaneous GZTs were identified only at histological examination. Benign GZTs reveal similar histomorphological features. In contrast, immunohistochemical studies yield conflicting results. Thus, cellular differentiation of GZT is still controversial. On current evidence, GZTs represent a distinct entity with a common histogeneis. The most widely accepted theory is that they originate from a cell in the peripheral nerve system, which has not yet been more precisely characterized.

Adult↗
PubMed1990

Demonstration of quinolone phototoxicity in vitro.

The 'first-generation' quinolones cinoxacin, nalidixic acid, oxolinic acid, pipemidic acid and rosoxacin and the newly developed quinolones ciprofloxacin, enoxacin, fleroxacin, norfloxacin and ofloxacin were screened in vitro at 10(-5), 10(-4) and 10(-3) M concentrations for ultraviolet (UV)-induced phototoxic effects in a photohemolysis test. At 10(-3) M, photodependent effects of norfloxacin could not be evaluated, as hemolysis occurred without irradiation. All other compounds with the exception of ciprofloxacin were found to be phototoxic at 10(-3) M and some also at 10(-4) M. Hemolysis was UV dose dependent and for all compounds most prominent after exposure to UVA-rich radiation except for fleroxacin which was most active in the UVB range. Besides fleroxacin, also oxolinic acid, pipemidic acid and rosoxacin induced hemolysis with irradiations rich in UVB. It is concluded that quinolones have to be regarded as potentially phototoxic substances. Therefore intense light exposure should be avoided during treatment with these agents.

Dose-Response Relationship, Radiation↗
PubMed1990

[UV exposure in the workplace. Apropos the establishing of threshold limit values].

Although UV exposure is present at many workplaces, it has not gained much attention. Particularly with regard to UVA, the UV threshold limit values for acute effects used to date are insufficient, and there are no obligatory limits to prevent the sequels of chronic UV exposure. More precise threshold limit values have been published only preliminarily (DIN-Standard No. 5031, part 10). There is a need for regulations governing the supervision of occupational UV exposure and the individual protection of exposed persons.

Dose-Response Relationship, Radiation↗
PubMed1990

[Subcutaneous dirofilariasis: infection with Dirofilaria repens].

A female patient resident in Germany is described, who had developed dirofilariasis presenting as a hard subcutaneous nodule at the glabella. Dirofilaria repens was isolated after surgical removal of the skin lesion. She was treated with diethylcarbamazine (Hetrazan) for 4 weeks. Exposures related to infection with Dirofilaria repens are discussed.

Animals↗
PubMed1989

[The Brocq pseudopelade--a disease picture or disease entity].

In 1885 Brocq described a type of scarring alopecia he called pseudopelade (PPB), whose character as a separate disease entity has been denied in recent decades. Several authors now believe PPB to be a polyetiological final stage (état pseudopeladique de Degos; EPP). In all, 142 patients with scarring alopecia were analyzed in an attempt to find whether PPB is a separate entity or not. Following examination, 26 cases with lichen ruber (LR), 18 cases with lupus erythematosus chronicus discoides (DLE), 2 cases with scleroderma, 1 case with folliculitis decalvans, and 1 case with ichthyosis vulgaris were diagnosed; this left 94 cases with PPB (66%). We attempt to describe the macroscopic morphology and histopathology in PPB and in LR and DLE. The findings yielded by direct immunofluorescence and the treatment are discussed.

Adolescent↗