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Biomedical subjects

T Bjurö

Publications and source records attributed to T Bjurö.

32 records · Page 2Linked to original sources

Physical training in man. Skeletal muscle metabolism in relation to muscle morphology and running ability.

The metabolic and morphologic adaptation to physical training in skeletal muscle tissue of eleven middle-aged, physically untrained men was studied. Muscle biopsies were taken from the vastus lateralis before, after 8 weeks and after 6 months of physical training for analysis of metabolic and morphologic variables. Glucose tolerance test indicated increased insulin sensitivity after 6 months of physical training. The activities of glycogen phosphorylase, hexokinase and glucose-6-P-dehydrogenase were increased but other enzymes involved in glycogen turnover and glycolysis were unchanged after 6 months of physical traning. The activities of citrate synthase and cytochrome-c-oxidase, representing the oxidative capacity were significantly increased already after 8 weeks of physical training. The incorporation rate of palmitate-carbon into CO2 and triglycerides increased, and the incorporation rate of leucine-carbon into CO2 decreased with 6 months of physical training. The fiber diameter of both Type 1- and Type 2-fibers increased, while the mitochondrial volume increased predominantly in Type 2-fibers. Significant correlations were found between metabolic, physiologic and morphologic variables before and after physical training. The results indicate an increased oxidative capacity, mainly located to Type 2-fibers, and an increased utilization of fatty acids in response to this type of physical training.

Carnitine↗

Ergonomic studies of standardized domestic work in patients with neuromuscular handicap.

A model for ergonomic studies of domestic work in varying patient groups has been constructed. A control group of 15 healthy women, 30-59 years of age, 9 female patients with hemiplegia and 13 with multiple sclerosis (MS) were studied with exercise test on a bicycle ergometer. Recordings of time consumption, heart rate and subjectively perceived exertion were made during a 4.5-5 hour domestic work program. Four of the more strenuous work elements were restudied also with respect to oxygen uptake. The hemiplegic patients required more time and had higher perceived exertion, but lower heart rate and oxygen uptake for the same work tasks than did the controls. The MS-patients also had higher perceived exertion. There was a rather poor relationship between determined and indirectly estimated energy expenditure. Various explanations are discussed. The results demonstrate the importance of the perceived exertion in choosing the work intensity.

Activities of Daily Living↗

The importance of nose-breathing for the systolic blood pressure rise during exercise.

The effect of nose breathing on the systolic blood pressure was examined in ten healthy men. Nose breathing was increased above normal by exercise and tested by maximum bicycle ergometry. When the anterior part of the nose was dilated with Nozovent the nasal airflow increased by on average 29%. In this condition, all ten men could cycle at maximum load without mouth breathing and there was a significantly lower increase (13 mmHg) in the systolic blood pressure than when the nasal dilator was not used. The reason for this lower blood pressure increase is unknown. The hypothesis is put forward, however, that facilitated nose breathing decreases the respiratory work, which in turn lowers the systolic blood pressure during exercise.

Adult↗