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Biomedical subjects

T Bodrogi

Publications and source records attributed to T Bodrogi.

At least 19 recordsLinked to original sources
PubMed1992

[Successful treatment of acute tubulointerstitial nephritis associated with infectious mononucleosis and causing severe uremia].

A ten years old boy with severe acute renal failure was presented. The development of acute uremia was proceeded by infectious mononucleosis. Renal biopsy revealed acute tubulointerstitial nephritis. Peritoneal- and haemodialysis was completed by steroid therapy and cytostatic treatment when glomerular proteinuria was observed. Following a 2 months uremic period the patient cured completely.

Acute Disease↗
PubMed1992

Hereditary nephritis, platelet disorders and deafness-Epstein's syndrome.

A 14-year-old boy with persistent proteinuria (1.6-4.0 g/day), microscopic haematuria, moderate hypertension, macrothrombocytopenia (giant platelets, platelet number 30 x 10(9)/l) and a familial sensorineural hearing loss (the father and the brother were also affected) was studied. Kidney biopsy revealed a diffuse mesangial proliferation, and a focal thickening of the glomerular basement membrane was seen on electron microscopy. A normal number of megakaryocytes was observed in bone marrow aspirates. The aggregation response of the platelets to collagen, epinephrine and adenosine diphosphate (ADP) was decreased. The platelet number was slightly diminished, platelets were of normal size in both parents and the brother, and showed a decreased aggregability in response to collagen, epinephrine and ADP in the brother and mother. No functional abnormality of the platelets was observed in the father. Urinalysis and kidney function were normal in the family members. This boy with nephritis, platelet disorders and hearing loss corresponds to Epstein's syndrome.

Adolescent↗
PubMed1992

The effect of erythropoietin on the cellular defence mechanism of red blood cells in children with chronic renal failure.

The glutathione redox system, haemoglobin (Hb) oxidation, the activity of antioxidant enzymes and the lipid peroxidation product malonyl dialdehyde (MDA) were studied in red blood cells (RBCs) during administration of recombinant human erythropoietin (rhEPO) over 12 weeks in ten children maintained on haemodialysis. A rapid increase in the reticulocyte count was accompanied by a slower rise in total Hb concentration. The mean level of oxidized glutathione (GSSG) increased from 13.2 +/- 5.3 nmol/g Hb to 56.7 +/- 15.8 nmol/g Hb 4 weeks after the start of rhEPO (P < 0.001), followed by a fall to the basal value. Reduced glutathione (GSH) levels showed a smaller though constant elevation during rhEPO therapy (P < 0.001). Before rhEPO treatment, incubation of RBCs for 1 h with acetylphenylhydrazine induced a decrease in GSH concentration compared with controls (P < 0.001), which became more pronounced in the first few weeks of rhEPO therapy (P < 0.001). In addition, the percentage of Hb derivatives (metHb and haemichrome) increased in the first 4 weeks of rhEPO therapy (P < 0.001). Although there was no significant difference between the values obtained preEPO and during EPO treatment, MDA levels were continuously higher and superoxide dismutase, catalase and glutathione peroxidase concentrations were lower than in the controls (P < 0.001). These results are compatible with oxidative damage to the RBCs in the early period of rhEPO therapy in children with end-stage renal failure. The GSH-GSSG system, as an important cellular defence mechanism of the RBCs, appears to be severely affected.

Adolescent↗
PubMed1991

[Macrothrombopenia, nephritis and hearing loss--a new case of Epstein syndrome].

A 14 years old boy with persistent proteinuria (1.6-4.0 g/day), microscopic haematuria, macrothrombocytopenia (giant platelets, platelet number 30 G/l), and a familial sensorineural hearing loss (the father and the brother were also affected) was studied. Kidney biopsy presented a diffuse mesangial proliferation, and a focal thickening of the glomerular basement membrane was seen on electron microscopy. With bone marrow aspiration normal number of megacaryocytes was observed. The aggregation response of the platelets was decreased on collagen, epinephrine and ADP but it was normal on aggristin. The presented case with nephritis, platelet disorders and hearing loss corresponds to Epstein syndrome, a variant of Alport's syndrome.

Adult↗
PubMed1990

Synergistic effect of promethazine with gentamycin in frequently recurring pyelonephritis.

The effects of promethazine were studied in children with frequently recurring pyelonephritis which was not associated with urological abnormalities. The results of three methods of treatment were compared: 10 children were given a combination of gentamycin and promethazine for 7 days (Group 1), 11 received gentamycin treatment alone for 10 days (Group 2), and 19 (Group 3) were on long-term oral antibiotic prophylaxis (5.6 +/- 2.1 years) with episodes of intensive treatment of recurrences. In a 3-year follow-up period, the number of pyelonephritis recurrences was significantly lower in Group 1 than in Groups 2 and 3. Six out of 19 children in Group 3 had renal scarring. The authors suggest a synergistic effect between gentamycin and promethazine therapy. Promethazine increases antibiotic sensitivity, which could contribute to the elimination of recurring urinary tract infections.

Adolescent↗
PubMed1989

[Recurrence of focal sclerosing glomerulonephritis in the kidney graft].

This is the first report on the recurrence of a glomerular disease in renal transplant in Hungary. The primary disease of the girl died at the age of 13 was focal sclerosing glomerulonephritis with slight mesangial cell proliferation. The first symptoms appeared at the age of 6.5 and they progressed rapidly. Four years later, because of the severe nephrotic syndrome and chronic renal failure, renal transplantation was performed with the synchronous removal of the patient's own kidneys. In the latter an interesting immunohistological finding has been observed: beside the usual positivities, the basement membrane of the distal tubule at the opposite side of the macula densa showed a strong reaction with anti IgM and a somewhat weaker positivity with anti C3 sera. The primary disease recurred very soon. A mesangial cell proliferation, however did not develop, in contrary to the primary disease, which contradicts the theory that the mesangioproliferative form would be a distinct clinicopathological entity.

Child↗
PubMed1989

[Multiple primary cancer of the colon and rectum].

Data of 33 patients operated on during 13 years because of primary multiple cancer of the colon are presented. The frequency of multiple occurrence was 4.1%. Synchronous tumors were observed in 1.8% (15 patients) and metachronous was (following 410 operations) 4.4% (18 patients). The attention is drawn to the relationship between polyps occurring simultaneously with colonic cancers and the following--metachronous tumors. Careful examinations must cover the period following the acute colon operation, as eliminating the cause of the emergency operation other--synchronous tumors or polyps may remain hidden. The significance of prevention and follow-up examinations in the treatment of metachronous tumors in stressed. It was stated that the malignancy and operability indices of the second tumor detected in this way did not differ significantly from the primary tumors. Preference was given to subtotal colectomy as operative principle in the treatment of metachronous cancers of the colon.

Aged↗
PubMed1986

The role of renal prostaglandin E as a possible modulator of cyclic AMP production in nephrotic syndrome.

Urinary prostaglandin E (PGE) and cyclic AMP (cAMP) excretions were studied by radioimmunoassay in children with nephrotic syndrome and in a control population. In cases with nephrotic syndrome there was a significant elevation in urinary PGE excretion and cAMP excretion was decreased. A positive correlation was found between urinary cAMP excretion and urinary osmolality (Uosm) and the ratio urine to plasma osmolality (Uosm/Posm); and a negative correlation between urinary cAMP excretion and urine volume. A negative correlation was observed between the values of PGE excretion and urinary cAMP. These data confirmed the role of PGE as a modulator of cAMP production, which was inhibited in the nephrotic syndrome.

Adolescent↗
PubMed1985

An in vitro steroid sensitivity test: antibody-dependent cellular cytotoxicity (ADCC) reaction of peripheral lymphocytes in children with nephrotic syndrome.

A steroid effect is described that can be measured in vitro; this was determined by means of the antibody-dependent cellular cytotoxicity (ADCC) method. Examinations on 15 children with nephrotic syndrome revealed a significant correlation between the steroid sensitivity measured in vitro and the clinical sensitivity to prednisolone. The in vitro measurement of steroid sensitivity yielded fast and reliable information on the effectivity of prednisolone treatment.

Antibody-Dependent Cell Cytotoxicity↗
PubMed1984

Serum and urinary arginine-esterase activity in paediatric kidney diseases.

Serum and urinary kallikrein activities were determined from the arginine-esterase activities in various groups of kidney diseases and were compared with urinary beta-glucuronidase excretion, urinary output, urinary protein content and creatinine clearance. Serum arginine-esterase activity was significantly augmented in the active stage of diffuse renal diseases but was not related to the severity of parenchymal damage. The values improved during remission; the enzyme activity in chronic uraemic patient was as low as in the control sera. There was a positive correlation between urinary output and serum arginine-esterase activity, and consequently serum kallikrein might have an enhancing effect on diuresis.

Adolescent↗
PubMed1984

Typing of HLA antigens in a child population with nephrosis syndrome.

Using the microlymphocytotoxicity test of Terasaki, HLA--A, B, Cw antigen typing was done for 37 antigens in 28 children with steroid-sensitive nephrosis and five children with steroid-resistant nephrosis. Evaluation was made by the chi 2 test as corrected by the method of Yeates. In steroid-sensitive nephrosis the frequency of HLA--B 8 antigen was 33.3% and in the resistant cases 40% as against 18.5% in the controls. The difference, however, was not significant, the B 12 and B 13 antigens were more frequent in both steroid-sensitive and resistant nephrosis, though not significantly.

Child↗