Biomedical subjects

T Boehm-Viswanathan

Publications and source records attributed to T Boehm-Viswanathan.

2 recordsLinked to original sources

PubMed2000

Is angiogenesis inhibition the Holy Grail of cancer therapy?

Over the last several decades, oncology research and cancer treatment have concentrated primarily on the cancer cells. Unfortunately, despite the intensive quest to find new and more effective compounds for chemotherapy, the survival rate of patients has not significantly changed. In 1971 Judah Folkman proposed that a solid tumor cannot grow without inducing angiogenesis. Intensive search for molecules blocking the formation of a tumor-nourishing capillary network has identified several promising agents in experimental models. Some of these angiogenesis inhibitors are in clinical trials, but a clear statement about the efficacy cannot be made yet. What are the current trends in angiogenesis research? What areas should we intensively investigate? Can we find the Holy Grail of cancer therapy in the years to come in order to stop the ineffable suffering of millions of cancer patients?

Angiogenesis Inhibitors↗

PubMed1999

Why angiogenesis inhibition? Commentary.

Over the last several decades, cancer research and therapy have focused primarily on tumor cells. However, in 1971 it was proposed that a solid tumor cannot grow without recruiting endothelial cells. The hypothesis was that if one can block the formation of an adequate capillary network, tumor growth could be inhibited. Antiangiogenesis research is undoubtedly very fashionable today but compounds effective in clinical trials have not been reported so far. The goal of this commentary is to discuss two questions: what are the limitations of the old, established antitumor paradigm? Second, what are the advantages of the antiangiogenesis paradigm? At this time it is important to convince more scientists that the inhibition of angiogenesis is a valid concept against tumor growth. A stronger momentum of the antiangiogenesis movement will hopefully result in finding more effective compounds against cancer growth.

Angiogenesis Inhibitors↗