PubMed Health⌕ Search

Biomedical subjects

T Bottema

Publications and source records attributed to T Bottema.

6 recordsLinked to original sources
PubMed1993

Pharmacological aspects of R-(+)-7-OH-DPAT, a putative dopamine D3 receptor ligand.

The R-(+)-isomer of 7-hydroxy-2-(N,N-di-n-propylamino)tetralin (7-OH-DPAT) bound with a more than 200-fold higher affinity to cloned human dopamine D3 receptors (Ki = 0.57 nM) than to dopamine D2 receptors; the corresponding S-(-)-enantiomer had considerably less affinity for both dopamine receptor subtypes, indicating that the known enantiomer selectivity of 7-OH-DPAT for the 'classical' dopamine D2 receptor subtype extends to the recently discovered dopamine D3 receptor subtype. In rats R-(+)-7-OH-DPAT dose dependently (10-1000 nmol/kg) decreased dopamine release and induced yawning, while sniffing behaviour occurred at the highest dose tested (1000 nmol/kg). The possibility that the inhibition of dopamine release and the elicitation of yawning are mediated by dopamine D3 receptors is considered.

Animals↗
PubMed1975

Spontaneous cerebrospinal fluid otorrhea. Congenital anomaly of bony labyrinth a possible cause.

A patient had recurrent meningitis as a result of a congenital anomaly of the bony labyrinth. As far as could be traced in the literature, this was the first time that an isolated congenital anomaly of the bony labyrinth could be shown to be the origin of spontaneous cerebrospinal fluid otorrhea and the resulting recurrent meningitis. In cerebrospinal fluid otorrhea of unknown origin, tomographic x-ray examination of the bony labyrinth is of utmost importance. For the detection of the finer details is the bony structure of the labyrinth, this tomography should be done according to one of the multidirectional techniques.

Adolescent↗