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Biomedical subjects

T C Lubensky

Publications and source records attributed to T C Lubensky.

At least 19 recordsLinked to original sources

Brownian motion of an ellipsoid.

We studied the Brownian motion of isolated ellipsoidal particles in water confined to two dimensions and elucidated the effects of coupling between rotational and translational motion. By using digital video microscopy, we quantified the crossover from short-time anisotropic to long-time isotropic diffusion and directly measured probability distributions functions for displacements. We confirmed and interpreted our measurements by using Langevin theory and numerical simulations. Our theory and observations provide insights into fundamental diffusive processes, which are potentially useful for understanding transport in membranes and for understanding the motions of anisotropic macromolecules.

Journal Article↗

Dynamics, dynamic soft elasticity, and rheology of smectic-C elastomers.

We present a theory for the low-frequency, long-wavelength dynamics of soft smectic-C elastomers with locked-in smectic layers. Our theory, which goes beyond pure hydrodynamics, predicts a dynamic soft elasticity of these elastomers and allows us to calculate the storage and loss moduli relevant for rheology experiments as well as the mode structure.

Journal Article↗

Nonaffine correlations in random elastic media.

Materials characterized by spatially homogeneous elastic moduli undergo affine distortions when subjected to external stress at their boundaries, i.e., their displacements from a uniform reference state grow linearly with position , and their strains are spatially constant. Many materials, including all macroscopically isotropic amorphous ones, have elastic moduli that vary randomly with position, and they necessarily undergo nonaffine distortions in response to external stress. We study general aspects of nonaffine response and correlation using analytic calculations and numerical simulations. We define nonaffine displacements as the difference between and affine displacements, and we investigate the nonaffinity correlation function and related functions. We introduce four model random systems with random elastic moduli induced by locally random spring constants (none of which are infinite), by random coordination number, by random stress, or by any combination of these. We show analytically and numerically that scales as where the amplitude is proportional to the variance of local elastic moduli regardless of the origin of their randomness. We show that the driving force for nonaffine displacements is a spatial derivative of the random elastic constant tensor times the constant affine strain. Random stress by itself does not drive nonaffine response, though the randomness in elastic moduli it may generate does. We study models with both short- and long-range correlations in random elastic moduli.

Biophysics↗

Poisson bracket approach to the dynamics of nematic liquid crystals: the role of spin angular momentum.

Nematic liquid crystals are well modeled as a fluid of rigid rods. Starting from this model, we use a Poisson-bracket formalism to derive the equations governing the dynamics of nematic liquid crystals. We treat the spin angular momentum density arising from the rotation of constituent molecules about their centers of mass as an independent field and derive equations for it, the mass density, the momentum density, and the nematic director. Our equations reduce to the original Leslie-Ericksen equations, including the inertial director term that is neglected in the hydrodynamic limit, only when the moment of inertia for angular momentum parallel to the director vanishes and when a dissipative coefficient favoring locking of the angular frequencies of director rotation and spin angular momentum diverges. Our equations reduce to the equations of nematohydrodynamics in the hydrodynamic limit but with dissipative coefficients that depend on the coefficient that must diverge to produce the Leslie-Ericksen equations.

Journal Article↗

Cracks and topological defects in lyotropic nematic gels.

We report on the effects of the coupling of nematic order and elasticity in anisotropic lyotropic gels consisting of large nematic domains of surfactant coated single wall carbon nanotubes embedded in a cross-linked N-isopropyl acrylamide polymer matrix. We observe the following striking features: (i) undulations and then cusping of the gel sidewalls, (ii) a nematic director field that evolves as the gel sidewalls deform, (iii) networks of surface cracks that are orthogonal to the nematic director field, and (iv) fissures at the sidewall cusps and associated topological defects that would not form in liquid nematics.

Anisotropy↗

A chiral granular gas.

Inspired by rattleback toys, we created small chiral wires that rotate in a preferred direction on a vertically oscillating platform and quantified their motion with experiment and simulation. We demonstrate experimentally that angular momentum of rotation about particle centers of mass is converted to collective angular momentum of center-of-mass motion in a granular gas of these wires, and we introduce a continuum model that explains our observations.

Journal Article↗

Nonlinear elasticity in biological gels.

The mechanical properties of soft biological tissues are essential to their physiological function and cannot easily be duplicated by synthetic materials. Unlike simple polymer gels, many biological materials--including blood vessels, mesentery tissue, lung parenchyma, cornea and blood clots--stiffen as they are strained, thereby preventing large deformations that could threaten tissue integrity. The molecular structures and design principles responsible for this nonlinear elasticity are unknown. Here we report a molecular theory that accounts for strain-stiffening in a range of molecularly distinct gels formed from cytoskeletal and extracellular proteins and that reveals universal stress-strain relations at low to intermediate strains. The input to this theory is the force-extension curve for individual semi-flexible filaments and the assumptions that biological networks composed of these filaments are homogeneous, isotropic, and that they strain uniformly. This theory shows that systems of filamentous proteins arranged in an open crosslinked mesh invariably stiffen at low strains without requiring a specific architecture or multiple elements with different intrinsic stiffness.

Biopolymers↗

Phase transitions and soft elasticity of smectic elastomers.

Smectic-C elastomers can be prepared by cross-linking, e.g., liquid crystal polymers, in the smectic-A phase followed by a cooling through the smectic-A to smectic-C phase transition. This transition from D(infinityh) to C(2h) symmetry spontaneously breaks rotational symmetry in the smectic plane as does the transition from a smectic-A to a biaxial smectic phase with D(2h) symmetry. We study these transitions and the emergent elasticity of the smectic-C and biaxial phases in three related models and show that these phases exhibit soft elasticity analogous to that of nematic elastomers.

Journal Article↗

Dynamics of nematic elastomers.

We study the low-frequency, long-wavelength dynamics of soft and semisoft nematic elastomers using two different but related dynamic theories. Our first formulation describes the pure hydrodynamic behavior of nematic elastomers in which the nematic director has relaxed to its equilibrium value in the presence of strain. We find that the sound-mode structure for soft elastomers is identical to that of columnar liquid crystals. Our second formulation generalizes the derivation of the equations of nematohydrodynamics by Forster et al. to nematic elastomers. It treats the director explicitly and describes slow modes beyond the hydrodynamic limit.

Journal Article↗

Elongation and fluctuations of semiflexible polymers in a nematic solvent.

We directly visualize single polymers with persistence lengths l(p), ranging from 0.05 to 16 microm, dissolved in the nematic phase of rodlike fd virus. Polymers with a sufficiently large persistence length undergo a coil-rod transition at the isotropic-nematic transition of the background solvent. We quantitatively analyze the transverse fluctuations of the semiflexible polymers and show that at long wavelengths they are driven by the fluctuating nematic background. We extract the Odijk deflection length and the elastic constant of the background nematic phase from the data.

Actins↗

Anomalous elasticity of nematic and critically soft elastomers.

Uniaxial elastomers are characterized by five elastic constants. If their elastic modulus C5 describing the energy of shear strains in planes containing the anisotropy axis vanishes, they are said to be soft. In spatial dimensions d less than or equal to 3, soft elastomers exhibit anomalous elasticity with certain length-scale-dependent bending moduli that diverge and shear moduli that vanish at large length scales. Using renormalized field theory at d=3 and to first order in epsilon=3-d, we calculate critical exponents and other properties characterizing the anomalous elasticity of two soft systems: (i) nematic elastomers in which softness is a manifestation of a Goldstone mode induced by the spontaneous symmetry breaking associated with a transition from an isotropic state to a nematic state, and (ii) a particular version of what we call a critically soft elastomer in which C(5)=0 corresponds to a critical point terminating the stability regime of a uniaxial elastomer with C5>0.

Journal Article↗

Nematic nanotube gels.

We report the creation of nematic nanotube gels containing large domains of isolated, oriented, half-micron-long, single-wall carbon nanotubes (SWNTs). We make them by homogeneously dispersing surfactant coated SWNTs at low concentration in an N-isopropyl acrylamide gel and then inducing a volume-compression transition. These gels exhibit hallmark properties of a nematic: birefrigence, anisotropy in optical absorption, and disclination defects. We also investigate the isotropic-to-nematic transition of these gels, and we describe the physical properties of their ensuing nematic state, including a novel buckling of sample walls. Finally, we provide a simple model to explain our observations.

Journal Article↗

Commentary on "Mechanical properties of monodomain side chain nematic elastomers" by P. Martinoty et al.

We discuss the rheology experiments on nematic elastomers by Martinoty et al. in the light of theoretical models for the long-wavelength low-frequency dynamics of these materials. We review these theories and discuss how they can be modified to provide a phenomenological description of the non-hydrodynamic frequency regime probed in the experiments. Moreover, we review the concepts of soft and semi-soft elasticity and comment on their implications for the experiments.

Anisotropy↗

Structure of twist-grain-boundary-C phases.

We study properties of the Renn-Lubensky twist-grain-boundary-C (TGB(C)) phase, with layer normal rotating in a plane perpendicular to the pitch axis, and the Bordeaux TGB(C) phase, with the layer normal rotating on a cone parallel to the pitch axis near the upper critical twist k(c2) marking the transition to the cholesteric phase. We introduce a generalized model free energy for the smectic-C phase that allows either TGB(C) phase to be stable, and we calculate k(c2) and the order-parameter profile, which shows only modest spatial variation, for both phases.

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Microrheology, stress fluctuations, and active behavior of living cells.

We report the first measurements of the intrinsic strain fluctuations of living cells using a recently developed tracer correlation technique along with a theoretical framework for interpreting such data in heterogeneous media with nonthermal driving. The fluctuations' spatial and temporal correlations indicate that the cytoskeleton can be treated as a course-grained continuum with power-law rheology, driven by a spatially random stress tensor field. Combined with recent cell rheology results, our data imply that intracellular stress fluctuations have a nearly 1/omega2 power spectrum, as expected for a continuum with a slowly evolving internal prestress.

Cell Physiological Phenomena↗

Fluctuating nematic elastomer membranes.

We study the flat phase of nematic elastomer membranes with rotational symmetry spontaneously broken by an in-plane nematic order. Such a state is characterized by a vanishing elastic modulus for simple shear and soft transverse phonons. At harmonic level, the in-plane orientational (nematic) order is stable to thermal fluctuations that lead to short-range in-plane translational (phonon) correlations. To treat thermal fluctuations and relevant elastic nonlinearities, we introduce two generalizations of two-dimensional membranes in a three-dimensional space to arbitrary D-dimensional membranes embedded in a d-dimensional space and analyze their anomalous elasticities in an expansion about D=4. We find a stable fixed point that controls long-scale properties of nematic elastomer membranes. It is characterized by singular in-plane elastic moduli that vanish as a power law eta(lambda)=4-D of a relevant inverse length scale (e.g., wave vector) and a finite bending rigidity. Our predictions are asymptotically exact near four dimensions.

Journal Article↗

Poisson-bracket approach to the dynamics of nematic liquid crystals.

We use the general Poisson-bracket formalism for obtaining stochastic dynamical equations for slow macroscopic fields to derive the equations that govern the dynamics of nematic liquid crystals in both their nematic and isotropic phases. For uniaxial molecules, we calculate the Poisson bracket between the tensorial nematic order parameter Q and the momentum density g, as well as those between all pairs of conserved quantities. We show that the full nonlinear hydrodynamical equations for the nematic phase derived in this formalism are identical to the nonlinear Ericksen-Leslie equations. We also obtain the complete dynamical equations for the slow dynamics of the tensorial nematic order parameter Q valid both in the isotropic and the nematic phase. They differ from those obtained by other techniques only in the values of kinetic coefficients and in the number of nonlinear terms in Q, which are present.

Journal Article↗

Rheological microscopy: local mechanical properties from microrheology.

We demonstrate how tracer microrheology methods can be extended to study submicron scale variations in the viscoelastic response of soft materials; in particular, a semidilute solution of lambda-DNA. The polymer concentration is depleted near the surfaces of the tracer particles, within a distance comparable to the polymer correlation length. The rheology of this microscopic layer alters the tracers' motion and can be precisely quantified using one- and two-point microrheology. Interestingly, we found this mechanically distinct layer to be twice as thick as the layer of depleted concentration, likely due to solvent drainage through the locally perturbed polymer structure.

Bacteriophage lambda↗