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Biomedical subjects

T C Nicholson

Publications and source records attributed to T C Nicholson.

7 recordsLinked to original sources
PubMed1978

Sandwich therapy in testis tumor: current experience.

Sandwich therapy, a regimen of lymphadenectomy combined with preoperative and postoperative cobalt teletherapy, yielded a survival rate of 84% in 13 patients with stages A and B non-seminomatous testis tumor. This statistic is consistent with the previously reported survival rate of 83% achieved among 35 patients treated with this regimen from 1958 to 1970 at our institution. Bone marrow depression, retroperitoneal fibrosis and possible induction of a second malignancy were important side effects of radiation therapy. The superior survival rates with fewer severe side effects of treatment obtained by other investigators using either lymphadenectomy alone or lymphadenectomy combined with chemotherapy have prompted us to discontinue sandwich therapy as standard treatment for non-seminomatous testis tumors at our institution.

Cobalt Radioisotopes↗
PubMed1977

Pelvic lymphadenectomy for stage B1 adenocarcinoma or the prostate: justified or not?

Of 47 consecutive patients who had undergone staging pelvic lymphadenectomy for clinically localized adenocarcinoma of the prostate 26 had clinical stage B1 disease. Only 2 of these patients (8 per cent) had positive pelvic nodes. The low incidence of lymphatic spread, the potential complications of lymphadenectomy and the role of regional lymphatics in generating an immunological defense raise the question of the efficacy of lymphadenectomy in the treatment of rigidly defined, clinical stage B1 adenocarcinoma of the prostate.

Adenocarcinoma↗
PubMed1975

The endocrinology of human chorionic gonadotropin-secreting testicular tumors: new methods in diagnosis.

Serum from 59 men with testicular masses was examined for the presence of human chorionic gonadotropin-beta. Results indicate: 1) In patients with testicular tumor human chorionic gonadotropin-beta serves as a sensitive and specific marker of tumor activity with an incidence of 28%. 2) Because human chorionic gonadotropin-beta levels correlate with response to therapy this test will be useful in selecting men for adjunctive irradiation or chemotherapy. 3) Radioimmunoassay for human chorionic gonadotropin-beta is far more sensitive and specific than conventional methods for detecting human chorionic gonadotropin production. 4) After unilateral orchiectomy for carcinoma of the testis elevated serum luteinizing hormone levels are common and may be unrelated to the presence or activity of residual tumor. 5) Human chorionic gonadotropin-beta-producing tumors were associated with increased estradiol and testosterone levels and significantly depressed serum follicle stimulating hormone levels in this series. 6) The prognostic implications of the presence of human chorionic gonadotropin-beta are not yet fully understood. The importance of this study is the fact that men with testicular tumors have a high incidence of human chorionic gonadotropin-beta secretion and this fact provides the physician with a powerful new tool for examining the various aspects of tumor activity. It also shows the feasibility for prospective screening of patients with a wide variety of neoplasms of differing histologic types.

Adolescent↗