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Biomedical subjects

T C O'Grady

Publications and source records attributed to T C O'Grady.

11 recordsLinked to original sources
PubMed2000

Verrucous carcinoma arising in hidradenitis suppurativa.

There are many reported cases of squamous carcinoma complicating hidradenitis suppurativa, but only one previous mention of verrucous carcinoma in this setting. We describe a case of verrucous carcinoma arising in hidradenitis suppurativa of the anal margin in a non-immunosuppressed man. This is the second report of verrucous carcinoma arising in a lesion of hidradenitis suppurativa. Although hidradenitis suppurativa can involve multiple intertriginous sites, malignant degeneration occurs mostly in the anogenital region. This suggests a role for a regional factor which, when combined with chronic inflammation, predisposes to malignant degeneration. A likely candidate for this factor is human papillomavirus; our case showed histologic evidence for this, but the specimen did not show viral DNA by polymerase chain reaction in situ hybridization. The ability of anogenital hidradenitis suppurativa to form squamous and verrucous cancers reinforces the argument for early and complete resection.

Anus Neoplasms↗
PubMed1999

Epithelioid blue nevus occurring in children with no evidence of Carney complex.

We report two pediatric patients who had biopsies of solitary lesions diagnosed as epithelioid blue nevi. Histologically these lesions had wedge-shaped, heavily pigmented infiltrates extending to the subcutaneous fat. The infiltrate was composed of spindled and polyhedral cells that were nevomelanocytic cells with nuclear pleomorphism. Also noted were pigmented globular cells interpreted as melanophages. These lesions have the same characteristics as those blue nevi occurring in patients with Carney complex. More recently, adult patients have been identified with similar nevi, but without evidence of Carney complex. To our knowledge, pediatric patients with epithelioid blue nevi, but no evidence of Carney complex have not been described previously.

Child↗
PubMed1996

Progressive eruptive histiocytomas.

We describe progressive eruptive lesions that have been appearing on a 50-year-old Filipino man for the past 9 years. They are characterized by smooth, brown, firm nodules mainly on the head and torso. Histologic examination shows dermal collections of lipid-filled histiocytes and Touton-type giant cells. A comparison with other types of previously described non-Langerhans cell histiocytoses is made.

Diagnosis, Differential↗
PubMed1996

Ossifying fibromyxoid tumor of soft parts: a case report and review.

Ossifying fibromyxoid tumor of soft parts is a recently described, rare but morphologically distinctive tumor of soft tissue, including subcutaneous soft tissue. We report a case of ossifying fibromyxoid tumor of soft parts which occurred in the subcutaneous tissue of a 68-year-old male, and review the clinical, histologic, and immunohistologic features of this tumor. Ossifying fibromyxoid tumor of soft parts tends to occur in the subcutaneous tissue and have been reported from the head and neck, upper and lower extremities, and trunk. Immunohistologic studies have supported a neural origin. While considered benign, local recurrence after excision is common and these tumors should be excised with clear margins to prevent recurrence.

Aged↗
PubMed1989

Mass eye casualties at sea.

During a "crossing the line ceremony" conducted aboard ship while returning from an extended deployment, 40 active duty sailors inadvertently received eye injuries from a chemical agent. The agent was suspected to be Magic Shave, a chemical depilatory powder containing calcium hydroxide as the active ingredient. Therefore, the resulting corneal burns were alkali in nature. Twenty of the 40 patients required admission to sick bay for 1 to 2 days. The remaining patients were followed on an outpatient basis. All patients were treated with irrigation of the affected eyes and most required patching for at least several days. No permanent eye disabilities resulted. The emergency treatment of chemical eye injuries is reviewed.

Burns, Chemical↗
PubMed1975

Chemical modification of yeast 3-phosphoglycerate kinase.

Sulfhydryl reagents, as well as mild hydrogen peroxide oxidation, do not inhibit the activity of yeast phosphoglycerate kinase, indicating that the single thiol group and 3 methionine residues present in the enzyme are not essential for activity. Nitration of phosphoglycerate kinase by tetranitromethane inhibits the enzyme by reaction with a single tyrosine residue. Substrates provide partial protection against inactivation by nitration. Circular dichroism spectra indicate that no conformational changes occur upon nitration. However, perturbation of the microenvironment surrounding the aromatic amino acid residues, particularly tyrosine, was observed. The same perturbation was observed on addition of the substrate 3-phosphoglycerate kinase to native phosphoglycerate kinase. The role of lysine in the action of yeast phosphoglycerate kinase has been studied by modification with O-methylisourea, 2-methoxy-5-nitrotropone, and pyridoxal phosphate. Guanidination shows that there are lysines essential for phosphoglycerate kinase; extrapolation to zero activity indicates that there are three essential lysines as judged by nitrotroponylation and three essential lysines when the enzyme is reacted with pyridoxal phosphate. Substrates afford partial protection and extrapolation to total protection indicates that up to three lysines are protected by MgITP and one lysine by 3-phosphoglycerate. Spectrofluorescence and optical rotatory dispersion measurements show that there is no detectable conformational change for the guanidinated phosphoglycerate kinase and that there are slight changes in the spectra suggesting that there may be slight conformational changes for the nitrotroponylated and the pyridoxal phosphate-modified enzymes.

Amino Acid Sequence↗