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Biomedical subjects

T C O'Neil

Publications and source records attributed to T C O'Neil.

9 recordsLinked to original sources
PubMed1987

Identification of Bacteroides species from adult periodontal disease.

Samples from deep (4-7 mm) periodontal pockets were collected from 17 patients with adult-type periodontal disease and one with the juvenile form of the disease. They were streaked immediately on selective and non-selective media and incubated anaerobically for 96 h. There was a heavy growth of Bacteroides spp. from most samples and 10 representative colonies from each sample were sub-cultured for identification. In a total of 149 isolates from patients with adult-type disease, the commonest species were B. oralis (40), B. asaccharolyticus (35), B. intermedius (31), B. fragilis (12) and B. ureolyticus (10); B. gingivalis was not detected. The distribution of species was not distorted by multiple identical isolates from individual patients. There was a heavy growth of a single species, B. ureolyticus, from the patient with juvenile-type disease.

Adolescent↗
PubMed1983

Multisystem sarcoid presenting with gingival hyperplasia.

A case is reported in which granulomatous gingival hyperplasia was the presenting feature of generalised sarcoidosis. Treatment with oral prednisolone resulted in resolution of both the granulomatous lesion of the gums, and of proteinuria. It is pointed out that although on histological examination sarcoidosis in this site cannot be distinguished from Crohn's disease, the clinical appearance in this patient (and the only similar case in the literature) was quite different from that seen in oral Crohn's disease.

Adolescent↗
PubMed1982

An investigation into the use of a force-indentation probe as a possible method of scoring inflammation in gingival tissue.

An attempt is described to use a hand-held force-indentation probe to investigate changes in the consistency of gingiva resulting from chronic inflammation. As the probe is hand-held the gingiva must be indented to about half its depth to reduce the error resulting from hand-shake. Thus the probe measures a combination of hardness and depth of the tissue, as confirmed by tests on rubber. The repeatability of the results obtained from the probe is good, though large variations can occur. Tests on rubber demonstrated that this was not due to the device or the hand-held technique. Force-indentation curves were obtained from 36 patients and were classified by buccal or papillae site and by the gingival index (GI) of two scorers. The mean force-indentation curves for each classification were compared and were found to be related to the GI, there being a significant difference between each pair of curves. Although there is no direct evidence that the force-indentation curves are measuring the same thing as the GI, the results show that the probe may be a useful tool in objectively studying changes in the condition of gingiva.

Adolescent↗
PubMed1979

Maternal T-lymphocyte response and gingivitis in pregnancy.

The exacerbation of a chronic gingivitis during pregnancy was confirmed in a group of 24 pregnant patients who were observed at the 14th and 30th weeks of pregnancy and postpartum. This exacerbation occurred despite a fall in the amount of plaque accumulation and confirmed that during pregnancy some factor in addition to plaque is involved in the increased inflammation. Using in vitro methods, it was shown that during pregnancy there is a depression of maternal T-cell responsiveness and it is suggested that this depression of the cell-mediated immune response could be a factor in the altered responsiveness of the gingival tissues to plaque. However lymphocytes responses to Veillonella alkalescens ultrasonicate (a plaque antigen) were generally poor and it was not possible to demonstrate any significant difference between the altered responsiveness of maternal lymphocytes to Veillonella and those of nonpregnant controls.

Adolescent↗
PubMed1979

Plasma female sex-hormone levels and gingivitis in pregnancy.

This investigation has confirmed that there is an increase in gingival inflammation between the 14th and 30th weeks of pregnancy and that this will occur despite a fall in the amount of plaque at the dento-gingival junction. This implicates a further factor in addition to plaque accumulation to explain the increased inflammmation. It was confirmed that there are marked increases in the plasma levels of estradiol and progesterone between the 14th and 30th weeks of pregnancy but it was not possible to demonstrate a direct association between these increases and the increase in gingival inflammation.

Dental Plaque↗
PubMed1975

Antibacterial properties of periodontal dressings.

The relationship between the build-up of bacterial plaque at the dento-gingival junction and the development of gingivitis is well established. The susceptibility of patients requiring periodontal surgery to the pathogenic potential of plaque would seem to necessitate the protection of the surgically treated area by a periodontal dressing until adequate plaque control by the patient is possible. In the light of clinical experience, an investigation was undertaken into the antibacterial properties of certain proprietary periodontal dressings and a zinc oxide/eugenol material. None of these materials showed any marked degree of antibacterial activity. One of these materials, Coe-Pak, had been used alone or combined with Cross Pack for all the patients in the clinical survey with very satisfactory results, and it is concluded that this material is successful because of its physical properties and not its antibacterial ones. Careful attention to asepsis, gentle and controlled tissue handling, correct technique, and thorough removal of plaque and calculus are the prerequisites for successful periodontal surgery. The protection of the surgical wound by a dressing of adequate physical properties aids in ensuring uneventful healing. The use of potent antibacterial agents in the dressing is not necessary; a physical barrier to salivary/bacterial contamination and food impaction may be the most important factor.

Anti-Infective Agents, Local↗