Biomedical subjects

T C Van Cader

Publications and source records attributed to T C Van Cader.

3 recordsLinked to original sources

PubMed1984

Limited joint mobility and diabetic retinopathy demonstrated by fluorescein angiography.

The association between limitation of finger joint mobility (LJM) and diabetic retinopathy demonstrable by fluorescein angiography was examined in 311 subjects aged 6-27 years. The relationship of these two complications was highly significant (P less than 0.0001). This was not the result of the effect of diabetes duration on both complications; interaction of LJM, retinopathy, and duration was not significant (P greater than 0.3). The presence of LJM was predictive of associated retinopathy at the level of clinical recognition (more than ten microaneurysms); 43% of those with LJM and duration beyond 4 years had retinopathy while only 15% of this duration group without LJM had clinical retinopathy.

Adolescent↗

PubMed1984

Risk factors for diabetic retinopathy in youth.

Retinal microvascular abnormalities were evaluated in 74 insulin-dependent diabetic youths by fluorescein angiography on two or more occasions spanning at least 4 years. Half of this group showed progression of the retinal vascular abnormalities from a stage of no significant abnormalities to at least background retinopathy with more than ten microaneurysms. Proliferative retinopathy requiring laser photocoagulation occurred in 14% (10/74). Insulin administration (once or twice a day) and glycemic control as reflected by hemoglobin A1C were identical in those with progression and in those with no progression of retinopathy. More females than males in this age group developed progressive retinopathy (P less than .036). Human lymphocyte antigen (HLA) types DR3 and DR4 in combination occurred more frequently (P less than .001) in those with progression of retinopathy than in those without progression. Teenaged , female, insulin-dependent diabetics with both HLA DR3, and DR4, were at increased risk for developing proliferative retinopathy.

Adolescent↗

PubMed1977

Diabetic vascular changes in children.

The microvascular complications of diabetes are demonstrated in the eye at a very early stage with the use of retinal fluorescein angiography. One hundred and fifty-four children who have had diabetes mellitus for durations varying from one month to 18 years had their retinal vasculature evaluated with fluorescein angiography. Seventy-five per cent of the children examined had vascular abnormalities, including 20 children who had diabetes for one year or less. Twenty-five per cent of the children showed no vascular abnormalities. This included one child who had diabetes for 12 years. The severity of the vascular abnormalities increased with the duration of diabetes. Vascular abnormalities did not appear related to diabetic management or control. The possibility of two types of diabetics, one with the other without associated vascular abnormalities, is suggested.

Adolescent↗