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Biomedical subjects

T Caulet

Publications and source records attributed to T Caulet.

At least 37 records · Page 2Linked to original sources

[Thymic carcinoid tumors. A clinico-anatomic study of 3 cases].

The carcinoid tumour of the thymus was first detailed by Rosai in 1972. The authors describe three cases of this tumour with particular reference to their histogenesis. It appears to be a tumour predominantly affecting males with an often unfavourable, though slow, progression. Some pathological associations are frequent and characteristic. In one third of cases there is an associated endocrine neoplasia. As a rule the tumour is sited in the anterior mediastinum. The precise diagnosis rests on histochemical criteria (specific granulations). These carcinoids are tumours of the APUD system of endodermal origin. The treatment is surgical.

Adult↗

[Study of thesaurismosis induced by perhexiline maleate. Confirmation of experimental data].

Perhexiline maleate is an amphiphilic molecule. Along with many other drugs it is responsible for experimental and, in some instances, clinical lipidoses. Sphingomyelinase deficiency has been evidenced in cell cultures incubated with perhexiline maleate. We describe the occurrence of a similar defect in a patient. The disturbances in the phospholipid turnover which are responsible for the thesaurismosis may originate in the sphingomyelinase deficiency.

Cerebellar Ataxia↗

[Labial embryonal rhabdomyosarcoma. Value of cell culture and electron microscopy, histogenesis].

The authors report the case of a labial embryonal rhabdomyosarcoma of a baby. This appears to be an exceptional localization. The study of the first biopsy which was too superficial leads to the thought of a capillary angioma. At the age of 6 months the lesion is 35 mm in diameter, a lobulated formation, typically botryoid. The excision after a frozen section control was in healthy tissue. At the age of 10 months, there is a local relapse with a nodule of 18 mm with left submandibular lymph nodes. A second surgical operation allows the culture of the tumoral tissue. The conventional histopathological examinations shows the aspect of an embryonal rhabdomyosarcoma. On the ultrastructural examination one can visualize in some cells an intracytoplasmic filamentous material. The cellular proliferation in culture, after May Grunwald Giemsa coloration is monomorphous, spindle shaped and of fibroblastic aspect. The ultrastructural study of this cellular proliferation after trypsinization on the 7th day shows some cells including an intracytoplasmic filamentous material. On the data of the cellular culture, the ultrastructural studies and the review of the literature, the authors discuss the possibility of the relationship between the cells of embryonal rhabdomyosarcomas and the fibroblasts and myofibroblasts. Embryonal sarcoma seems to be a better denomination than embryonal rhabdomyosarcoma, as regards the histogenesis.

Age Factors↗

[Phenotype of T lymphocytes and macrophages obtained by broncho-alveolar lavage of human lung].

T lymphocytes and macrophages, isolated and purified from broncho-alveolar lavages performed in normal controls and in patients with various alveolar structure diseases were identified using monoclonal antibodies against different membrane markers. For T lymphocyte subsets, our results are consistent with previous observations showing a large number of lung helper T cells in patients with sarcoidosis with high-intensity alveolitis. For macrophage subsets, we pointed out, for all cases, a weak expression of monocyte markers.

Antibodies, Monoclonal↗

[Multicentric granular cell tumor of the tracheobronchial tree].

The authors describe a case of multicentric endotracheobronchial myoblastoma with one endotracheal localization and two bronchial localizations. The patient underwent resection of the inferior lobe of the left lung. The tracheal tumor was not removed. Two years after surgery the patient is doing well. Several biopsy specimens have been removed from the tracheal tumor which has remained unchanged. Cases such as ours are very uncommon. Therapeutic decisions may be difficult.

Bronchial Neoplasms↗

[Biliary hamartoma. Reflexions on a new personal case].

In this study of a personal case of biliary hamartoma showing complete aplasia of the hepatic parenchyma as well as a cystic ectasy of the corresponding bile ducts, particular emphasis has been laid on the clinical, paraclinical and anatomo-pathological aspects of these dysgeneses. There seems to be an analogy between the radiographic, anatomical and anatomo-pathological studies made in this case and those that could have been made in pulmonary sequestration. As regards the pathogenesis of these complaints, the authors therefore put forward the same hypothesis for biliary hamartoma as for pulmonary sequestration and highlight the advantages of pre-operative angiography.

Angiography↗

[Hemangioendothelioma of the right supra-clavicular region. Clinicopathologic study and management. Report of a case (author's transl)].

The authors present a case of hemangioendothelioma of the right supra-clavicular region in a 14-year-old boy. Interest of scanner in extension bilan and supraselective arteriography with tumor embolisation are stressed. Complete excision was possible and no sign of recurrence is noted 18 months later. Essential characteristics of a such tumor are reviewed.

Adolescent↗

[Malignant histiocytosis simulating histiocytosis with massive sinusal lymphadenopathy, on the first lymph node biopsy (author's transl)].

The case of a 36 year old man who presented prominent bilateral cervical lymphadenopathies is reported. The diagnosis of sinus histiocytosis with massive lymphadenopathy (Rosai and Dorfman, 1969) was retained on account of a massive hyperplasia of foamy histiocytes with PAS + inclusions, lipidic storage and hemocytophagy in the sinuses and cords of the lymph nodes. The patient died after 34 months evolution. At the autopsy an important proliferation by large atypical sometimes multinucleated cells in the lymph nodes, liver, bone and spleen was found, as observed in malignant histiocytosis. The ultrastructural study confirmed the histiocytic nature of the cells. The interest of immunohistochemical studies on paraffin embedded material with characterization of tumor histiocytes with lysozyme and alpha 1 antichymotrypsin is discussed. This report described an unusual form of malignant histiocytosis simulating on his early phase sinus histiocytosis with massive lymphadenopathy.

Adult↗