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Biomedical subjects

T Chajek

Publications and source records attributed to T Chajek.

33 records · Page 2Linked to original sources
PubMed1976

Quinidine hypersensitivity and liver involvement. A survey of 32 patients.

Thirty-two of 487 patients who received quinidine between the years of 1970 and 1974 in the departments of medicine at Hadassah University Hospital developed hypersensitivity reactions. Ten of the 32 patients had clinical and biochemical manifestations of liver invlovement. In 4 patients liver biopsy showed granulomatous hepatitis. It is therefore concluded that quinidine-induced hepatitis is a relatively common side effect of this drug.

Chemical and Drug Induced Liver Injury↗
PubMed1976

Ultrastructural localization of concanavalin A in the perfused rat heart.

Staining of the surface coat of heart capillaries and aorta was achieved by perfusing concanavalin A and phytohemagglutinin coupled to horseradish peroxidase through the rat heart. The binding of these lectins provides evidence for the presence of glycoproteins containing mannose, glucose, and N-acetylgalactosamine residues in the endothelial surface coat of rat aorta and heart capillaries. The binding of concanavalin A to capillary endothelium was further followed with radioautography of 125I-labeled concanavalin A in the in vitro perfused rat heart. Following the shorter time intervals of perfusion more than 80 per cent of labeled concanavalin A was releasable by alpha-methyl-D-mannoside and the radioautographic reaction was confined to the endothelial cell surface. Following 60 minutes of perfusion with concanavalin A there was translocation of part of the lectin to the extravascular space and evidence of endothelial cell swelling. A tentative estimate of the concanavalin A binding sites in capillary endothelium was determined to be approximately 5000 per sq. mum.

Animals↗
PubMed1975

Interference with the transport of heparin-releasable lipoprotein lipase in the perfused rat heart by colchicine and vinblastine.

The effect of pretreatment with colchicine or vinblastine on the lipoprotein lipase activity of rat heart was studied. Administration of colchicine or vinblastine 4 h prior to perfusion of the heart caused a very marked reduction in lipoprotein lipase activity released into the perfusate within 1 min of heparin perfusion. At the same time an increase in residual heart lipase occurred so that total lipoprotein lipase content of the heart (heparin releasable plus residual) did not change. The colchicine effect was dose and time dependent; no decrease in heparin-releasable enzyme activity occurred after only 30 min of pretreatment or upon addition of colchicine into the perfusate. These results indicate that colchicine did not impede enzyme synthesis or its release from the cell surface, but may have interfered with the transport of lipoprotein lipase from the site of its synthesis to the endothelial cell surface.

Animals↗
PubMed1975

Colchicine-induced inhibition of plasma lipoprotein lipase release in the intact rat.

The release of plasma lipoprotein lipase by heparin was studied in fed and food-deprived rats pretreated with colchicine and vinblastine. Four hours after the administration of either drug the lipoprotein lipase activity released by heparin was only half of that found in controls. Colchicine affected the release of both protamine-sensitive and protamine-resistant lipoprotein lipase. It is suggested that colchicine and vinblastine interfere with the transport of lipoprotein lipase from the site of its storage to the vascular cell surface.

Animals↗
PubMed1975

Behçet's disease. Report of 41 cases and a review of the literature.

Several important conclusions may be derived on the basis of our experience with Behcet's disease (B.D.) and a review of the literature, namely: 1. B.D. is a systemic disease characterized by exacerbations and remissions of unpredictable duration, which affects mainly males between the ages of 20 to 30 years. Although its incidence is higher in the eastern hemisphere cases presented in all parts of the world. 2. The common histopathological lesion of all clinical manifestations appears to be a vasculitis. The etiology of B.D. is unknown. A viral etiology has been proposed but not confirmed. The presence of autoantibodies and lymphocyte sensitization to mucosal antigen has been observed but the precise significance of these findings in relation to the pathogenesis of the disease is presently undetermined. 3. The clinical manigestations present in most of the patients and considered diagnostic for B.D. are oral and genital ulcers, uveitis and skin lesions (especially erythema nodosum-like lesions or non-specific skin reactivity to needle pricks). The presence of three of the above manifestations are obligatory for the diagnosis. The other common clinical manifestations occurring in B.D. are: arthritis (44%); thrombophlebitis (24%), and various neurological syndromes (18%). Less frequent complications of the disease include: arterial thrombosis and aneurysm of both the systemic and pulmonary circulation, colitis, epididymitis and orchitis. 4. The serious chronic sequelae of this disease consist of blindness in up to 33% of patients with uveitis, vena caval obstruction and paralysis of limbs. Mortality, usually caused by meningoencephalitis, is rare. 5. The patients may present to different medical specialities, e.g., dermatology, gynecology, ophthalmology, neurology and internal medicine. To facilitate the correct diagnosis the essential criteria should be actively sought as they are not always the cause for medical consultation. 6. The diagnosis of B.D. is based only on clinical grounds as there are no pathognomonic laboratory or histopathological features. 7. Evaluation of treatment in B.D. is difficult, because of the naturally unpredictable course of the disease. Many drugs have been tried in the treatment of B.D. including antibiotics, anti-inflammatory drugs and corticosteroids, all with equivocal effects. Recently several additional treatment schedules have been suggested. Immunosuppressive drugs have been shown to have some beneficial effect, especially on uveitis. Fresh blood or plasma transfusions may prolong remissions. 8. The finding of decreased plasma fibrinolytic activity in patients with active B.D. represents the first observation of a possible disturbance in the blood coagulation mechanism and suggests that the use of fibrinolytic agents may be rewarding.

Adolescent↗