Retrospective analysis of treatment of acute myeloblastic leukemia in patients more than 55 years old.
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Biomedical subjects
Publications and source records attributed to T Chisesi.
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The cytotoxic activity of Hodgkin serum on some isolated T and B lymphocyte populations of 10 normal subjects, 10 patients with Hodgkin disease in the acute phase and 10 patients with Hodgkin disease but in clinical and biohumoral remission was studied. The effect of citotoxic serum variously affects the two different lymphocyte populations, particularly inhibiting LIF activity of T lymphocytes, while stimulating LIF activity of B lymphocytes. The possible causes of this phenomenon are set forth as well as their clinical implications.
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The relationship of HbA2 to total Hb has been measured in 204 cases of Beta-Thalassaemia (beta-th-t) where the total Hb varied from 3.6 to 16 g/100 ml. The variation of total Hb in the study population was due, as far as could be defined, only to beta-th-t and a superimposed iron deficiency anaemia (IDA). Superimposed IDA decreases HbA2 proportionately more than it does total Hb (P less than 0.001). A not previously described relationship between HbA2 and total Hb was demonstrated and probably conformed to a second degree parabola.
The simultaneous occurrence of two serum and urine M components in a 75-year-old woman affected by Hodgkin's disease is reported. The patient developed two IgG-M components of different light-chain types after an episode of pneumococcal pneumonia.
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16 patients with chronic liver or haematologic diseases were parenterally given various doses of Desferrioxamine B (DF). Each daily dose of DF (from 1 to 4 g) was given for a 7 days cycle. Liver, kidney and blood functions were investigated at the first and seventh day of each cycle, and 1 and 2 weeks after therapy was stopped. 1 g/day and 2 g/day had no side effects, with the exception of a fall of white blood cell (WBC) count in a single case on 2 g/day. 3 g/day (15 patients) were followed by rises of blood urea, creatinine, alkaline phosphatase and glutamyl-transpeptidase respectively in 4 cases, and by falls of WBC count in 3 cases. 4 g/day (9 patients) caused rises of creatinine, GPT and GOT (1 case) or LDH (1 case), while WBC count dropped in 4 cases. All changes were reversible within one-two weeks. These recorded changes were outside the range of pretreatment values as obtained over the previous four weeks.
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Antigenic material related to the fibrin stabilizing factor (Factor XIII-FSF) has been found in all the examined patients with congenital deficiency, albeit in reduced amount. Recently, Bohn et al. (1973) showed that plasma Factor-XIII is composed by two subunits, A (or a) and S (or b); the former active protein, the latter probably FSF-vinding protein. Using specific anti-S and anti-A antisera the Authors found, in a case of congenital deficiency of factor XIII, absence of subunit A. Subunit S presented abnormal behaviour as demonstrated by means of quantitative immunoelectrophoresis according to Laurell.
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