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Biomedical subjects

T Christ

Publications and source records attributed to T Christ.

At least 19 recordsLinked to original sources
PubMed1992

[Are metipranolol eyedrops responsible for intraocular side effects?].

Metipranolol is a beta-blocker that has been used in ophthalmology and in systemic therapy for about 10 years. Reports about reversible uveitis under the product Glauline (metipranolol-containing eye drops) in England were the reason for extensive studies with metipranolol-containing eye drops produced with different methods. Analytical studies concerning the influence of irradiation sterilization on the drug containers, studies on the toxicity of the ophthalmic drug on tissue cultures, and prospective and retrospective clinical studies on 2,800 glaucoma patients were performed. Irradiation sterilization leads to the formation of free radicals on the surface of the containers and, depending on the radiation dose, to a decrease in the pH of the drug solution. In prospective studies involving 1,516 glaucoma patients, no intraocular side effects due to metipranolol-containing eye drops were found. In the retrospective examination including 1,306 glaucoma patients, 19 cases of uveitis were found. Thirteen cases of recurring iritis were diagnosed, which had already been observed before the onset of glaucoma therapy. In 2 cases the iritis led to secondary glaucoma and was treated with metipranolol. In 2 cases glaucoma was treated with pilocarpine (and dipivefrin) and metipranolol concomitantly. One case of rubeosis iridis was incorrectly classified as iritis. One case is possibly related to metipranolol despite the assessment to the contrary by the ophthalmologist in question. Following the results of these studies, an accumulation of cases of uveitis caused by metipranolol can be excluded.

Adolescent↗
PubMed1987

[Normal values in the Aulhorn flicker test].

In this paper the results of the Aulhorn flicker test in 105 healthy subjects are described. With decreasing flicker frequencies there was an increasing sensitivity to brightness below the individual flicker fusion frequency. These results contrast with those obtained in patients with acute optic neuritis. In these patients the sensitivity to brightness decreased at low flicker frequencies. The range of frequency intervals between 3 and 50 Hz in which the maximum increase in brightness sensitivity was be observed was also investigated. The results have been compiled in a diagram for clinical use.

Adolescent↗
PubMed1987

[Gelatinous tear substitutes and nonspecific eye ointments in the critical care unit and in perioperative use].

The effect of Vidisic (a new jelly artificial tear solution) and an ointment basing on Dexpanthenol on the tear production and the tear film stability was studied both on patients in the intensive care units (ICU) and during operations. In 10 relaxed and ventilated patients of the ICU there was no significant change in the tear production after application of either therapy. In 30 patients, undergoing surgery in endotracheal anaesthesia, the break-up-time and the test according to Schirmer were measured pre- and postoperatively. Like in the ICU-patients no difference in tear production could be found. Regarding the stability of the precorneal tear film however Vidisic was more effective than ointment basing on Dexpanthenol. Especially this clear jelly artificial tear solution allowed in contrast to the ointment a permanent and reliable judgement of the pupillary reaction. In addition the patients felt more comfortable with Vidisic.

Acrylates↗
PubMed1986

[A test of pressure tolerance of the optic nerve head in ocular hypertension].

VER was recorded in 7 patients with ocular hypertension while intraocular pressure was artificially elevated. Four of the patients manifested signs of vascular autoregulation, while in 3 no such signs were observed. This absence of autoregulation was also observed in primary open-angle glaucoma patients. On the basis of these first results it may be expected that the pressure compliance test will identify patients with ocular hypertension in whom damage to the optic disk is likely to occur at a later date.

Adult↗
PubMed1986

[Corneal contact time of artificial tear solutions].

In 30 subjects without ophthalmological disease the corneal contact time of a new artificial polyacrylic-based tear gel (Vidisic, produced by Dr. Mann, Berlin) was compared with a well-known artificial polyvinyl alcohol-based tear solution. The Vidisic concentration remained in the corneal tear film 7 times longer than the substance it was compared with. In a second study including 7 normal subjects and 5 patients with keratoconjunctivitis sicca, the influence of Vidisic on break-up time (BUT) and the Schirmer test was demonstrated. It was found that tear secretion improved for 2-4 hours (Schirmer test) and the stability of the tear film (BUT) improved for about 6 hours with Vidisic. These results suggest that application of Vidisic four times a day is sufficient for efficatious therapy even in cases of severe keratoconjunctivitis sicca.

Acrylates↗
PubMed1986

The 'flicker test' according to Aulhorn in the diagnosis of acute optic neuritis.

The flicker test, introduced by Aulhorn is a new simple method to detect acute optic neuritis. We examined 24 patients suffering from acute optic neuritis. 23 patients showed a pathological result. In 179 subjects (patients with other ophthalmological diseases and healthy persons) the flicker test always showed normal results. After restitution of acute optic neuritis the results of the flicker test return to normal while the visual evoked responses remain pathological in many cases. Thus the flicker test can be an efficient tool in the diagnosis and differential diagnosis of acute optic neuritis.

Acute Disease↗
PubMed1985

Autoregulation of ocular blood flow during changes in intraocular pressure. Preliminary results.

Visual evoked potentials were recorded in six normal subjects and in three patients with primary open-angle glaucoma, while intraocular pressure was artificially elevated in stepwise increases. The resulting perfusion-pressure amplitude curves in our controls showed a kink, which can be interpreted as a sign of vascular autoregulation. No kink was observed in the curves of our glaucoma patients, which we interpret as indicating a lack of vascular autoregulation in primary open-angle glaucoma.

Adult↗
PubMed1985

[Ulrich oculo-oscillodynamography: initial results in carotid stenoses].

Oculo-oscillodynamography (OODG) after Ulrich was performed in 11 patients suffering from a monolateral, hemodynamically relevant carotid stenosis identified by Doppler sonography. All of the pressure parameters which can be measured by OODG--systolic retinal, systolic ciliary, and diastolic ocular perfusion pressure--were low on the side concerned. In contrast to the already-established methods of measuring ocular perfusion--ophthalmodynamometry and ophthalmodynamography after Hager--the advantages of OODG are that it not only enables the systolic retinal pressure to be differentiated from the systolic ciliary or diastolic ocular perfusion pressure, but also permits the results of the investigation to be illustrated graphically, so that objective evaluation is possible.

Aged↗
PubMed1985

[Ocular hemodynamics in central and branch artery occlusions].

Ocular oscillodynamograms (OODG) were made in 9 patients with an occlusion of the central artery and 11 patients with an occlusion of one branch artery. While there were no pathologic findings in patients with branch artery occlusions, it was not possible to record any systolic-retinal oscillations of the pulse in patients with an occlusion of the central artery. In three cases the systolic ciliary perfusion pressure was also low owing to carotid stenosis.

Adult↗
PubMed1985

[Computer tomography in partial optic nerve avulsion].

An partial avulsion of the optic nerve was found after a blunt ocular trauma in a 34-year old-patient. For the first time it is possible to demonstrate CT exposures of such a case. The importance of this method in cases of blunt ocular trauma accompanied by hemorrhages of the anterior chamber or the vitreous is discussed.

Adult↗
PubMed1985

Flicker fusion frequency and organic syndrome in alcoholics.

Flicker fusion frequencies of 48 healthy controls and of 35 alcoholics were measured to detect possible associations between flicker fusion and signs of nonspecific brain damage, the aim of the study. FFF was statistically significantly lower in patients addicted to alcohol than in healthy subjects. Lower flicker fusion frequencies were associated with the severeness of organic psychosis as rated psychopathologically. The hypothesis that addiction to alcohol is a sign of diffuse, nonspecific, organic brain damage was discussed.

Adult↗