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Biomedical subjects

T D Bol'shakova

Publications and source records attributed to T D Bol'shakova.

At least 19 recordsLinked to original sources
PubMed1991

[A comparative evaluation of methods of determining melanogen in the urine of patients with steroid-dependent bronchial asthma].

Fifty-four patients with steroid-dependent asthma of varying severity during exacerbation were examined to compare the efficacies of urinary melanogen measurement techniques. Jaksch's, Tormelen's methods, and the technique with 2M sulfuric acid were used. The tests were positive in but 3 (15%) patients with a medium severe course of the process and in 23 (68%) ones with a grave condition. Jaksch's and Tormelen's tests were similar in sensitivity, and the hydrochloric acid test was less demonstrative. Melanuria manifestation may be regarded as an early preclinical sign of adrenal insufficiency. Pigment metabolism studies in patients treated with steroids for a long time may be used as an extra method for the assessment of adrenocortical function and for monitoring the course of glucocorticosteroid therapy.

Adrenal Cortex Hormones↗
PubMed1991

[Morphofunctional state of the heart and activity of the kallikrein-kinin system in patients with chronic heart failure during treatment with captopril].

Coronary patients with heart failure (HF) stage I-III received captopril. The drug was found to attenuate symptoms of HF, to reduce the size of the left heart, to improve contractility. For stage HF I, kallikrein urinary excretion was similar to that of normal subjects, while in stage II-III patients it fell significantly. Captopril induced a drop in relevant secretion for stage I and a rise for stage II-III subjects. The drug administration did not influence the relations between the initial serum Na levels and kallikrein urinary excretion, nor it changed serum levels of Na and K. Alterations in morphofunctional characteristics of the heart and changes in diurnal urinary excretion of kallikrein demonstrated close relationships.

Aged↗
PubMed1991

[The effect of physical training on the indices of the general hemodynamics and kinin-kallikrein system activity in hypertension patients].

Forty men aged 30-60 years suffering from stage-II essential hypertension were examined for the general hemodynamics, the level of prekallikrein (PK) and kallikrein-like activity (KLA) of blood plasma, and kallikrein excretion with urine. The examinations were made before and after 30 weeks of exercise. Before such a course of exercise the response of the cardiovascular system and of the kinin-kallikrein system (KKS) to exercise was characterized by a significant rise of systolic, diastolic medium-hemodynamic arterial pressure, heart rate and kallikrein excretion with urine together with the lack changes in PK and KLA of blood plasma. No correlations were established between the KKS, which is likely to be determined by the disease. After the course of exercise there was a significant reduction of all the initial characteristics of the general hemodynamics, KLA, a close to significant increase of the PK level and a well-defined tendency towards lowering of kallikrein excretion with urine, and less remarkable response of all the parameters of both systems to standard exercise. A reverse correlation (r = -0.57) was established between the PK level and KLA at rest which may attest to a positive influence of exercise on the recovery of the correlations between the parameters of the KKS.

Adult↗
PubMed1990

[Immunoenzyme analysis of insulin antibodies in human blood serum].

Indirect solid-phase enzyme immunoassay (EIA) was used for the titration of antibodies to insulin in human blood sera. The modification suggested by the authors permits assessing the immunoglobulins G and M insulin-binding ability. The technique was optimized for all the stages of analysis and a method for estimating the insulin-binding ability of IgG in the sera diluted 1:80 and of IgM in the sera diluted 1:320 was developed. Fifty blood sera of patients with insulin-dependent diabetes mellitus were analyzed. EIA results were in good correlation with the findings of radioimmunoassay.

Diabetes Mellitus, Type 1↗
PubMed1990

[A photometric method of determining the activity of antithrombin III using a peptide coumarylamide substrate].

Toz-Gly-Pro-Arg-4-methylcoumaryl-7-amide is recommended for antithrombin-III (AT-III) photometry as a substrate. This substrate is cleaved by thrombin at 366 nm. AT-III photometry with this substrate is in accord with the requirements to methods used in clinical laboratory diagnosis, and the results of such measurement are in good correlation with the data of AT-III analysis with Chromozym-TH substrate. Use of photometry with methylcoumaryl substrates for measuring protease activities is more available than the traditional fluorometry.

Antithrombin III↗
PubMed1990

[The treatment of patients with the hemorrhagic form of erysipelas by using amben and parmidine].

Amben (fibrinolysis inhibitor) and parmidin (bradykinin inhibitor) were used as pathogenetic treatment of 38 and 36 patients with hemorrhagic erysipelas respectively. Early amben treatment proved clinically rather effective and was accompanied by normalization of fibrinolysis and kallikrein-kinin system. Parmidin treatment resulted only in pain control, other subjective signs, normalization of the kallikrein-kinin system while fibrinolysis activity was maintained at former levels.

4-Aminobenzoic Acid↗
PubMed1989

[The kallikrein-kinin system in pregnant women with gestosis before and during complex therapy].

Blood and urinary levels of kallikrein-kinin system were studied with chromogenic substrates both in healthy pregnant females and those with gestoses before and under the combined treatment. The activation of kallikrein-kinin system in treatment. The activation of kallikrein-kinin system in pregnancy was established as was the interrelation of kinin and plasma body systems. Kallikrein excretion with urine was found dependent on gestosis severity and the correlation between active kallikrein and its preliminary stage in the plasma. Alterations revealed should be considered in the course of combined treatment if preparations possible of affecting the kallikrein-kinin system were used.

Adolescent↗
PubMed1988

[Serine protease activity in blood plasma during the healing of aseptic and infected wounds under experimental conditions].

Activity of serine proteases--kallikrein-like activity (KLA) and plasmin-like activity (PLA)--were studied in the blood plasma of 220 sexually mature male Wistar rats with simulated aseptic and infected surface wounds in the time course before the operation, daily from the 1st to 10th day, as well as 12 and 15 days after the surgery. During the healing of aseptic and especially infected wound blood plasma KLA and PLA were found to be decreasing, thus indicating the active role of factor-XII-dependent systems in wound healing, reflecting the response of the body to operation-induced injury and wound infection, and dependent on the character and stage of wound healing course.

Animals↗
PubMed1988

[Effect of adaptation to stress exposures on the cholino- and adrenoreactivity of the atria and their content of acetylcholine in rats with myocardial infarct].

The effect of left-ventricular myocardial infarction (MI) on cholino- and adrenoreactivity of an isolated right atrium and acetylcholine (AC) content of both atria was evaluated experimentally in Wistar rats, adapted or unadapted (control) to stress. In the control sample, 24-hour-long MI increased the chronotropic response to AC, while atrial endogenic AC dropped fourfold. Those changes were accompanied by no marked changes in pacemaker adrenoreactivity. Adaptation to stress reduced pacemaker choline reactivity without any significant effect on pacemaker adrenoreactivity or atrial AC. At the same time, adaptation largely prevented MI-induced increase in pacemaker choline reactivity and atrial AC drop. Increased pacemaker choline reactivity, seen in MI, enhances pacemaker sensitivity to cognition of ectopic excitation foci and, hence, cholinergic effects, that may promote the emergence of arrhythmia. Therefore, pacemaker resistance to cholinergic action, increasing in the course of adaptation, may be an important element of the protective antiarrhythmic effect of adaptation to stress in MI.

Acetylcholine↗
PubMed1988

[Effect of myocardial ischemia on prostacyclin and thromboxane levels in arterial and coronary venous blood].

Variations in arterial and venous blood prostacyclin and thromboxane were examined in 32 patients with coronary heart disease, neurocirculatory dystonia and the cardialgic syndrome, exposed to cardioselective stress as a result of the atrial stimulation test. Prostacyclin and thromboxane measurement in blood specimens obtained from the left ventricle and the coronary venous network may provide additional markers of myocardial ischemia in cases where diagnosis is otherwise difficult to make.

Adult↗