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Biomedical subjects

T D Lavery

Publications and source records attributed to T D Lavery.

7 recordsLinked to original sources
PubMed1990

Erythropoietic protoporphyria. The problem of a suitable screening test.

Erythropoietic protoporphyria (EPP) is characterized by increased red cell protoporphyrins and is included in the differential diagnosis of children presenting with photosensitivity. In the past 20 years, using the traditional solvent extraction qualitative screening test for blood porphyrins, the diagnosis of EPP had been missed in 9 out of 10 patients but recently, using fluorescence microscopy of erythrocytes, no patients with EPP have been missed. All 14 patients in Northern Ireland known to have EPP were recalled and it was found that fluorescence microscopic determination was positive in all cases. We recommend fluorescence microscopy as the screening test of choice for the detection of increased red cell porphyrins.

Child↗
PubMed1984

Plasma cholinesterase activity and the duration of suxamethonium apnoea in children.

Plasma cholinesterase activity and the duration of suxamethonium apnoea were studied in 89 children and in 15 adults for comparison. Whereas the level of cholinesterase activity was not different in the two groups, children showed a significantly shorter duration of apnoea. There was poor correlation between the enzyme activity and duration of apnoea. The shorter duration of action of suxamethonium may be due to the larger volume of extracellular fluid in children.

Adult↗
PubMed1983

Plasma cholinesterase levels following pancuronium and vecuronium.

Plasma cholinesterase levels were measured in 52 patients following administration of pancuronium 1 mg/70 kg (10 patients) and 0.1 mg/kg (10 patients) and vecuronium in doses of 1 mg/70 kg (10 patients), 0.1 mg/kg (10 patients) and 0.2 mg/kg (12 patients). Both doses of pancuronium produced a significant (P less than 0.05 - less than 0.005) reduction in the enzyme levels. Vecuronium in a dose of 1 mg/70 kg was without any significant effects but the two higher doses produced a dose-related reduction of about 8 and 16% in the enzyme levels, respectively, which was statistically significant (P less than 0.05 - less than 0.001).

Anesthesia, Inhalation↗
PubMed1982

Effects of neostigmine and pyridostigmine on serum cholinesterase activity.

Serum cholinesterase activities were measured from 270 minutes in patients following administration of neostigmine or pyridostigmine for the reversal of pancuronium block in groups of seven patients each. The enzyme activities were significantly depressed by neostigmine for four hours and by pyridostigmine throughout the whole period of study. Whereas the immediate effects of neostigmine were more intense, the effects of pyridostigmine beyond the first 30 minutes were more profound. The clinical relevance of these findings is discussed.

Adult↗
PubMed1978

Relation of high-density lipoprotein cholesterol concentration to type of diabetes and its control.

Serum cholesterol and high-density lipoprotein (HDL) cholesterol concentrations were measured in 192 diabetics (94 with juvenile-onset and 98 with maturity-onset diabetes) and 177 non-diabetic controls. Hb A1C, an index of blood sugar control, was also measured in the diabetics. Serum cholesterol concentrations were similar in all the diabetics and controls, but HDL cholesterol concentrations were lower in patients with maturity-onset diabetes than in those with juvenile-onset diabetes and controls. There was no correlation in diabetics between HDL cholesterol and Hb A1C. We conclude that HDL cholesterol concentrations are abnormally low in patients with maturity-onset diabetes but essentially normal in those with juvenile-onset diabetes. They are not related to diabetic control.

Adult↗