PubMed Health⌕ Search

Biomedical subjects

T Daly

Publications and source records attributed to T Daly.

26 records · Page 2Linked to original sources
PubMed1987

Hemodynamic evaluation of ibuprofen in canine hypovolemic shock.

This study was done to evaluate the role of ibuprofen, a cyclooxygenase inhibitor, in a standard model of hypovolemic shock. Fifteen dogs were subjected to fixed mean arterial blood pressure (MABP) shock (40-45 mmHg) for 45 min and then treated with physiologic saline (NS), low-dose ibuprofen (6.25 mg/kg), and high-dose ibuprofen (12.5 mg/kg) by IV bolus and continuous IV infusion. After 60 min of treatment, the shed blood was returned. Survival was monitored for 72 h. Both dose levels resulted in a significant increase in MABP and total peripheral resistance over NS during the infusion period but heart rate, cardiac output, and left ventricular contractility were similar for all groups. Survival at 72 h was also similar for the three groups. Ibuprofen treatment, while increasing MABP and total peripheral vascular resistance did not seem to alter cardiac function or improve survival when compared to NS in this model of hypovolemic shock.

Animals↗
PubMed1986

Late administration of methylprednisolone does not enhance naloxone effect in hypovolemic shock.

The late addition of methylprednisolone (MP) in our canine hypovolemic shock protocol was evaluated to determine whether any hemodynamic enhancement of the naloxone (NAL) effect might be present. Thirty-four dogs were bled to a mean arterial pressure (MAP) of 40-45 mm Hg and held there for 45 minutes. All animals were then treated (T = 0) with 0.9% NaCl (NS) or NAL. In two groups of animals, MP (30 mg/kg) was given as an IV bolus 30 minutes after initiating NS or NAL therapy. At 60 minutes, the infusions were stopped and the shed blood was returned. Animals treated with NAL with or without MP showed improvement in MAP, maximal left ventricular contractility (LVdP/dt max), and cardiac output (CO) compared to NS. We found little hemodynamic improvement with the addition of MP at T = 30 for either the NAL or NS. Plasma endorphinlike activity (PELA) values decreased during treatment in the groups receiving NAL. Survival was improved in all groups except those receiving NS, but survival was statistically better only in the group that received NAL.

Animals↗
PubMed1977

Procedures for radioimmunoassay of the mouse mammary tumor virus.

A procedure for radioimmunoassay of the major glycoprotein antigen derived from murine mammary tumor virus is described. The assay is sensitive to 0.05 ng of antigen and is highly reproducible. The antigen, gp55, has been found to be group specific and will detect viruses in 13 separate mouse strains, as wel .l as from continuous cell lines. Factors affecting the assay have been examined.

Animals↗
PubMed1976

Utilization of a low-lactose milk.

This study was undertaken to determine if a milk containing prehydrolyzed lactose, yet affording full nutritional benefits, could be ingested by a milk intolerant (MI) population without the symptoms of lactose intolerance. MI was defined by the failure of serum glucose to rise greater than 20 mg/100 ml after ingestion of 50 gm of lactose as well as by subjective and objective symptoms and signs after consumption of both 12.5 gm of lactose in water and 250 ml of skim milk. Lactose tolerance (LT) was evidenced by both lack of symptoms and a concomitant rise in serum glucose of greater than 20 mg/100 ml after ingestion of 50 gm lactose in water. A series of four, two hr tolerance tests were given to 12 MI patients and 12 LT controls. The following solutions were employed: 12.5 gm lactose, 250 ml skim milk. 250 ml low-lactose skim milk, and 6 gm glucose plus 6 gm galactose. In the MI group, significant differences were apparent between the tolerance test utilizing skim milk and that using low-lactose skim milk; no such differences were observed in the LT group. These observations indicate that in the MI population the lactose in skim milk was poorly absorbed or tolerated, but after hydrolysis the low-lactose skim milk was well tolerated. A MI individual then, appears able to absorb the monosaccharides of the prehydrolyzed milk and can, furthermore, tolerate the low-lactose skim milk without suffering from symptoms normally associated with lactose intolerance.

Animals↗
PubMedDate not supplied

Biological hazards.

This article outlines the biological hazards that nurses may face in their workplace. It hopes to inform nurses how they can reduce such hazards at work and contribute to a safer working environment.

Hazardous Substances↗