Biomedical subjects

T Dintelmann

Publications and source records attributed to T Dintelmann.

3 recordsLinked to original sources

PubMed2005

[Botulinum toxin injection-treatment of upper lid retraction in thyroid eye disease].

OBJECTIVE: Upper lid retraction associated with thyroid eye disease may result in conjunctival and corneal exposure as well as in an esthetic problem. We evaluated the effect of botulinum toxin injections in order to lower the upper lid. METHODS: This prospective study included 19 eyes of 13 female patients presenting with scleral exposure aged 28-50 years. We injected 5-15 IE botulinum toxin A (Botox) transconjunctivally into the levator muscle. Lid position, negative side effects, and patient satisfaction were evaluated. RESULTS: Lid retraction improved from 2.4 mm (+/-1.4 mm) prior to injection to 0.5 mm (+/-2.3 mm) 4 weeks after injection. In 11 of 19 eyes 4 weeks after injection and in 8 of 14 eyes 12 weeks after injection scleral exposure had resolved. Diplopia did not occur and tear production was not influenced. Two eyes had transient ptosis. Lid lag increased from 0.34 (+/-0.6 mm) to 0.84 mm (+/-0.9 mm). Of 13 patients, 8 were satisfied with the result. CONCLUSION: Botulinum toxin A injection provides effective treatment especially in mild lid retraction and as a temporary solution for patients with unstable thyroid disease.

Adult↗

PubMed2004

Plasma exchange for severe optic neuritis: treatment of 10 patients.

The authors reviewed a series of 10 consecutive patients treated with plasma exchange (PE) for acute, severe optic neuritis (ON) largely unresponsive to previous high-dose IV glucocorticosteroids. PE was associated with an improvement of visual acuity according to the study criteria in 7 of 10 patients. On follow-up, three of these patients continued to improve, two remained stable, and two had worsened again. PE may be beneficial as an escalating treatment in a subset of patients with severe ON. A controlled trial is warranted.

Adult↗

PubMed2002

[Filtering bleb revision. Techniques and outcome].

BACKGROUND: The surgical management and outcome of bleb-related complications such as leaking blebs,overfiltration and blebitis are reported. METHODS: A retrospective analysis was carried out of 35 patients who underwent surgical repair of the filtering bleb in our hospital between 1991 and 2000. RESULTS: Surgical techniques used were autologous blood injection, fibrin glue injection, conjunctival suturing, resuturing of the trabeculectomy flap, bleb excision, conjunctival advancement, lyodura and tenon patching. In the eyes with leaking blebs the mean preoperative intraocular pressure (IOP) was 11.6+/-10.3 mmHg. After an average followup of 12 months the IOP was 11.9+/-3.3 mmHg. In the eyes with overfiltration the mean IOP was 2.4+/-1.5 mmHg and after an average follow-up of 18 months the mean IOP increased to 13.5+/-3.7 mmHg. In 77.1% the IOP was regulated between 8 and 21 mmHg without glaucoma medication. Mean visual acuity improved by 3.6+/-5.9 lines postoperatively. CONCLUSION: Surgical bleb revision has a high success rate with regard to maintaining a functioning filtering bleb and to preserving vision.

Adolescent↗